Effect of suplatast tosilate, a Th2 cytokine inhibitor, on cough variant asthma

Shioya, Takanobu; Satake, Masahiro; Sano, Mitsuru; Kagaya, Makoto; Watanabe, Akiko; Sato, Kazuhiro; Ito, Takeshi; Ito, Nobuaki; Sasaki, Masahiro; Miura, Mamoru

doi:10.1007/s00228-002-0468-z

Cited by 34 publications

(27 citation statements)

References 13 publications

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“…The coughing induced by ACE inhibitors is often not responsive to antitussives. Also, it has been reported that suplatast is clinically effective for the treatment of chronic coughs such as cough associated with atopic cough and CVA [5,6]; this is consistent with the present electrophysiological findings.…”

Section: Discussionsupporting

confidence: 82%

“…It has also been reported that bakumondo-to is clinically effective against chronic cough in asthmatic patients with cough hypersensitivity [12,13]. Recently, it has been reported that suplatast improved the cough scores and the cough threshold for capsaicin in patients with CVA [6]. The coughing in patients with CVA has been found to be resistant to the treatment with other antitussive drugs [19].…”

Section: Discussionmentioning

confidence: 99%

“…CVA, the major cause of chronic cough, is characterized only by chronic dry cough [4] and is not relieved by an inhaled codeine [2]. It has been reported that suplatast [suplatast tosilate, ±-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-toluenesulfonate] improves the cough score and the cough threshold for capsaicin in patients with atopic cough and CVA [5,6]. Suplatast, an anti-allergic drug, is a selective Th2 cytokine inhibitor [7] that suppresses the synthesis of IL-4 and IL-5 in vitro [8,9] as well as allergen-induced increases in peritoneal eosinophils in mice [8].…”

Section: Introductionmentioning

confidence: 99%

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Novel Antitussive Effect of Suplatast Tosilate in Guinea Pigs

Zhou¹,

Syono²,

Fukumi³

et al. 2015

Pharmacology

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We studied the antitussive effects of suplatast, a Th2 cytokine inhibitor, and compared them with the effects of codeine using an experimental cough model in guinea pigs. Suplatast and codeine dose-dependently inhibited cough caused by mechanical stimulation of the larynx, but they did not inhibit cough caused by mechanical stimulation of the bifurcation of the trachea. In guinea pigs with bronchitis, suplatast had an antitussive effect on cough caused by stimulation of the larynx, whereas codeine did not inhibit such cough. In SO₂-exposed guinea pigs, suplatast tended to inhibit cough caused by mechanical stimulation of the tracheal bifurcation. Further, suplatast inhibited citric acid-induced cough augmented by pretreatment with an angiotensin-converting enzyme inhibitor, whereas codeine did not inhibit such cough. Suplatast also inhibited bradykinin-induced discharges of airway vagal afferent nerves and significantly inhibited 4-aminopyridine-induced discharges of airway vagal afferent nerves. These findings indicate that the antitussive effects of suplatast are mediated by a novel mechanism involving the peripheral nervous system.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel Antitussive Effect of Suplatast Tosilate in Guinea Pigs

Zhou¹,

Syono²,

Fukumi³

et al. 2015

Pharmacology

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“…Some reports have shown that suplatast tosilate is an effective cough treatment [37, 38] because it improved airway cough hypersensitivity induced by airway allergy and cough by cough-variant asthma. Thus, suplatast tosilate may be an effective treatment for the cough associated with eosinophilic pneumonia.…”

Section: Discussionmentioning

confidence: 99%

A Case of Eosinophilic Pneumonia Successfully Treated with Suplatast Tosilate Alone

Watanabe

Hirata²,

Makino³

et al. 2009

Int Arch Allergy Immunol

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We report a case of eosinophilic pneumonia that was successfully treated with suplatast tosilate. A 72-year-old woman with hypertension and diabetes, who did not smoke and did not have pets, consulted a physician with the chief complaints of cough, sputum, and slight fever. Chest X-ray films revealed a permeation shadow in the bilateral upper lobes. She visited a hospital because her symptoms did not improve. Pulmonary tuberculosis was suspected because of an elevated inflammatory reaction, and anti-tuberculosis treatment was started. Afterwards, eosinophilia appeared in the peripheral blood. Although daily drugs (nicardipine hydrochloride, pentoxifylline, and ticlopidine hydrochloride) were stopped, eosinophilia did not improve and was detected in a sputum sample. She was diagnosed with pulmonary infiltration with eosinophilia syndrome and hospitalized. Physical examination revealed neither rhonchus nor cardiac murmurs on auscultation. Laboratory findings showed a leukocyte count of 21,300/μl, with eosinophils accounting for 66.3% of cells. A diagnosis of eosinophilic pneumonia was made after a lung biopsy specimen was examined under a bronchial fiberscope. After suspension of anti-tuberculosis drugs and administration of suplatast tosilate 300 mg/day for 4 weeks, symptoms subsided, eosinophilia improved to within normal ranges, eosinophils in sputum disappeared, and the permeation shadow disappeared on chest X-ray films.

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“…Suplatast (suplatast tosilate, ((±)-[2-[4-(3-ethoxy-2-hydroxy-propoxy) phenylcarbamoyl] ethyl] dimethylsulfonium p-toluenesulfonate)) is a selective Th2 cytokine inhibitor [9] and improves the cough score and the cough threshold for capsaicin in patients with cough variant asthma [10]. Previously, we found that suplatast inhibits codeine-resistant coughs in guinea pigs with bronchitis or treated with an angiotensin-converting enzyme inhibitor [11].…”

Section: Introductionmentioning

confidence: 99%

Direct Potentiation of Capsaicin Current by Histamine and Its Effect by Suplatast on Rat Trigeminal Ganglia Neurons

et al. 2018

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In this study, we investigated the effect of histamine on capsaicin-induced current and its influence by suplatast in rat trigeminal ganglia neurons using a patch-clamp technique. We found that histamine directly potentiated capsaicin-induced currents in rat sensory neurons, and suplatast had little effect on this potentiation. Since it has been known that suplatast suppresses histamine release from mast cells, it is possible that suplatast inhibits the activation of nociceptive fibers in the pathological condition via prevention of histamine-induced potentiation of the transient receptor potential vanilloid 1 receptor-mediated currents.

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Effect of suplatast tosilate, a Th2 cytokine inhibitor, on cough variant asthma

Cited by 34 publications

References 13 publications

Novel Antitussive Effect of Suplatast Tosilate in Guinea Pigs

Novel Antitussive Effect of Suplatast Tosilate in Guinea Pigs

A Case of Eosinophilic Pneumonia Successfully Treated with Suplatast Tosilate Alone

Direct Potentiation of Capsaicin Current by Histamine and Its Effect by Suplatast on Rat Trigeminal Ganglia Neurons

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