Effect of Sulfonamide Compounds on Transient Bacteremia Following Extraction of Teeth

Pressman, R.S.

doi:10.1001/archinte.1944.00210230038003

Cited by 30 publications

(3 citation statements)

References 19 publications

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“…The medicament initially utilized was the sulfonamides after the manipulations of infected teeth (Hageman, 1940; Paquin, 1941; Rhoads et al , 1950). Penicillin started to be used in dentistry as mouth rinse and remedy, and was very important in the management of periodontal disease (Hageman, 1940; Paquin, 1941; Geiger, 1942; Pressman and Bender, 1944;Rhoads et al , 1950). Rhoads advocated the removal of foci under the protection of antibiotic therapy (Rhoads, 1948).…”

Section: The Great Evolution Of Scientific and Technology Knowledge Imentioning

confidence: 99%

The history of dentistry and medicine relationship: could the mouth finally return to the body?

Vieira

Caramelli

2009

Oral Diseases

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The relationship between dentistry and medicine has been acknowledged throughout the history of humanity. This relationship was documented in ancient medicine accounts, and has survived until the present day, accompanied by the evolution of molecular technologies. Although we have had very important researchers' contributions in this interdisciplinary area, mainly after the 18th century, the knowledge on oral infections is still ignored by or unknown to the majority of clinical dentists and physicians. These circumstances could be changed through a broader divulgation of this complex relationship, both in the dentistry and in the medicine areas, which in turn would have a significant impact in systemic health worldwide. This movement has already started, as was observed in a World Health Assembly resolution which called for oral health to be integrated into chronic disease prevention programs in 2007. This was a significant indicator of changing perceptions of oral health over the past several decades. This brief review reports the evolution through time of the knowledge on the association between dental infections and systemic diseases, as well as the paths which we could take to consolidate this historical trend.

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Section: The Great Evolution Of Scientific and Technology Knowledge Imentioning

confidence: 99%

The history of dentistry and medicine relationship: could the mouth finally return to the body?

Vieira

Caramelli

2009

Oral Diseases

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“…Using sulphanilamide, Pressman and Bender (1944) obtained 7 % reduction (from 83 % to 76%) and Northrop and Crowley (1943) 5*4% reduction (from 15% to 9 6%). With penicillin the reductions varied from 9 % (Hirsch, Viveno, Merril, and Dowling, 1948) to 42 % (Schirger, Martin, Royer, and Needham, 1960).…”

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confidence: 92%

An effective antibiotic cover for the prevention of endocarditis following dental and other post-operative bacteraemias

Khairat

1966

Journal of Clinical Pathology

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SYNOPSIS Pre-and post-extraction blood cultures were taken from 242 patients. The post-extraction ones were taken from 100 unpremedicated patients, from 42 with an erythromycin estolate cover, and from 100 patients after protection with pyrrolidino methyl tetracycline. The 100 post-extraction blood cultures from unpremedicated patienits gave 64 positive results which yielded 155 strains, 88 of which were not aerobes.One hundred and fifteen representative strains were tested for sensitivity to 22 antibiotics. Of the 42 patients who received the erythromycin orally, 16 yielded positive blood cultures of mixtures of aerobes and anaerobes and of the 100 given one intravenous injection of the tetracycline three only developed a bacteraemia of a single type of aerobe. The serum concentrations obtained with the tetracycline given intravenously were 15 to 20 times higher than the serum levels obtained with the erythromycin given orally.There is a strong indication for using this kind of efficient antibiotic cover for dental extractions and other operative procedures known to be followed by a bacteraemia.Bacterial endocarditis is in many cases the result of bacteraemia produced by operative procedures, among which is tooth extraction. It is stated that 25 to 50% of endocarditis patients had one or more teeth extracted some two months before the onset of the valvular ailment (Cates and Christie, 1951). Northrop and Crowley (1943) reported 23 such cases, and 94 other cases are on record by various other authors.The bacteraemia of tooth extraction is transient, lasts about 10 minutes (Northrop and Crowley, 1943; Okell and Elliott, 1935), and the bacteria are most numerous in the blood stream within the first two minutes of their introduction into the circulation (Reichel, 1939). In persons with heart valves damaged by rheumatic fever, syphilis, or a congenital defect, the platelet-and-fibrin thrombi on the surface of the diseased valves trap some of the bacteraemic organisms, which then multiply and start an endocardial vegetation. The circulation time from the site of a tooth socket to an elbow vein is less than 18 seconds (Koch, 1922 56For an antibiotic cover during dental extraction various investigators tried sulphonamide compounds, penicillin, and other antibiotics, but all except one failed to isolate one single anaerobe in their unpremedicated post-extraction control blood cultures. Using sulphanilamide, Pressman and Bender (1944) obtained 7 % reduction (from 83 % to 76%) and Northrop and Crowley (1943) 5*4% reduction (from 15% to 9 6%). With penicillin the reductions varied from 9 % (Hirsch, Viveno, Merril, and Dowling, 1948) to 42 % (Schirger, Martin, Royer, and Needham, 1960). With antibiotics other than penicillin the reductions were 61 % (Khairat: the present work, the highest reduction ever obtained, in a series of 100 patients with 88 anaerobes isolated), 44 % (Roth, Cavallaro, Parrott, and Celentano, 1950) with aureomycin orally, 280% (Bender, Pressman, and Tashman, 1958) using streptomycin sulphate intra...

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“…Most reports describe use of only aerobic culture media, or thioglycolate medium. Only five reports emphasized and described use of anaerobic culture conditions (5,11,12,15,16) such as the Brewer jar. None of these employed the prereduced medium technology (4,9).…”

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confidence: 99%

Bacteremia After Tooth Extractions Studied with the Aid of Prereduced Anaerobically Sterilized Culture Media

Crawford¹,

Sconyers²,

Moriarty³

et al. 1974

Applied Microbiology

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Both prereduced molten agar and broth and aerobic molten agar and broth were inoculated with blood samples collected from patients with periodontitis, but in otherwise good health, both before and after extraction of two or more teeth. Postoperative blood samples from 23 of 25 patients sampled yielded anaerobic and facultative species. Colony counts from nine samples yielded from less than 1 to over 100 colonies per ml of blood. Organisms detected were species belonging to the genera Bacteroides, Fusobacterium, Peptostreptococcus, Leptotrichia, Propionibacterium, Peptococcus, Veillonella, plus Streptococcus mitis, S. salivarius, vibrio forms, and strains resembling S. mutans. The data indicate that prereduced anaerobically sterilized culture medium with polyanethol sulfonate is effective for detecting anaerobic species in bacteremia and that anaerobic species can be prevalent in bacteremias immediately after tooth extraction in patients with periodontitis.

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Effect of Sulfonamide Compounds on Transient Bacteremia Following Extraction of Teeth

Cited by 30 publications

References 19 publications

The history of dentistry and medicine relationship: could the mouth finally return to the body?

The history of dentistry and medicine relationship: could the mouth finally return to the body?

An effective antibiotic cover for the prevention of endocarditis following dental and other post-operative bacteraemias

Bacteremia After Tooth Extractions Studied with the Aid of Prereduced Anaerobically Sterilized Culture Media

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