Effect of Sulfation on the Structure and Anticoagulant Activity of Ulvan Extracted From Green Seaweed Ulva Reticulata

Thu, Quach Thi Minh

doi:10.15625/2525-2518/54/2c/11863

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…Thus, the degree of sulfation does not seem to be the only parameter affecting the anticoagulant activity of ulvans. Other polyanionic polysaccharides from various origins have been shown to have an anticoagulant activity strongly related to their degree of sulfation ([43,44,46,47]: sulfated fucans, in particular, have been extensively studied and their activity has been proved to be mainly mediated by thrombin inhibition by either antithrombin or heparin cofactor II, at different extents. However, numerous studies on sulfated fucans and galactans [60,61,62], and more recently on carrageenans [63], also established that anticoagulant activity, particularly in terms of efficiency, is not merely a function of charge density and depends critically on other structural features [46,47]: monosaccharide composition, glycosidic bounds, MW [50], branching residues, and position of sulfate groups on the sugar backbone [18,60].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the anticoagulant activity, the most studied genera are Codium [31,32,33,34,35,36], which contains sulfated arabinans and arabinogalactans, and then Monostroma , which contains sulfated rhamnans [37,38,39,40,41,42]. Only two studies have shown the potential anticoagulant properties of ulvans extracted from Ulva conglobata and Ulva reticulata [43,44].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, Cianca et al have demonstrated that sulfated galactans extracted from Codium fragile and Codium vermilara with a high MW and high sulfate content have a higher anticoagulant activity than LMW and low sulfate content polysaccharides [36]. Furthermore, the only published studies that have highlighted a strong activity of sulfated rhamnans from the Ulva genus were based on highly sulfated ulvans (sulfate content of 26–35%) [43,44].…”

Section: Introductionmentioning

confidence: 99%

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Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida

Adrien

Bonnet

Dufour³

et al. 2019

Marine Drugs

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(1) Background: Brown and red algal sulfated polysaccharides have been widely described as anticoagulant agents. However, data on green algae, especially on the Ulva genus, are limited. This study aimed at isolating ulvan from the green macroalga Ulva rigida using an acid- and solvent-free procedure, and investigating the effect of sulfate content on the anticoagulant activity of this polysaccharide. (2) Methods: The obtained ulvan fraction was chemically sulfated, leading to a doubling of the polysaccharide sulfate content in a second ulvan fraction. The potential anticoagulant activity of both ulvan fractions was then assessed using different assays, targeting the intrinsic and/or common (activated partial thromboplastin time), extrinsic (prothrombin time), and common (thrombin time) pathways, and the specific antithrombin-dependent pathway (anti-Xa and anti-IIa), of the coagulation cascade. Furthermore, their anticoagulant properties were compared to those of commercial anticoagulants: heparin and Lovenox®. (3) Results: The anticoagulant activity of the chemically-sulfated ulvan fraction was stronger than that of Lovenox® against both the intrinsic and extrinsic coagulation pathways. (4) Conclusion: The chemically-sulfated ulvan fraction could be a very interesting alternative to heparins, with different targets and a high anticoagulant activity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida

Adrien

Bonnet

Dufour³

et al. 2019

Marine Drugs

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“…The results obtained by these authors also indicate that the PS fractions from different types and species of brown algae, enriched with sulfates, but poor with uronic acids, exhibit relatively high activity, while the fractions with the inverse ratio of these structural components have a weaker anticoagulant activity. As for PSs from different types of green algae, it also was demonstrated that high-molecular-weight sulfated galactans with a high content of sulfates have a higher anticoagulant activity than low-molecular-weight PSs with a low content of sulfates [ 31 , 32 , 33 ].…”

Section: Anticoagulant Antithrombotic and Fibrinolytic Activities Of Seaweed Sulfated Polysaccharidesmentioning

confidence: 99%

The Potency of Seaweed Sulfated Polysaccharides for the Correction of Hemostasis Disorders in COVID-19

et al. 2021

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Hemostasis disorders play an important role in the pathogenesis, clinical manifestations, and outcome of COVID-19. First of all, the hemostasis system suffers due to a complicated and severe course of COVID-19. A significant number of COVID-19 patients develop signs of hypercoagulability, thrombocytopenia, and hyperfibrinolysis. Patients with severe COVID-19 have a tendency toward thrombotic complications in the venous and arterial systems, which is the leading cause of death in this disease. Despite the success achieved in the treatment of SARS-CoV-2, the search for new effective anticoagulants, thrombolytics, and fibrinolytics, as well as their optimal dose strategies, continues to be relevant. The wide therapeutic potential of seaweed sulfated polysaccharides (PSs), including anticoagulant, thrombolytic, and fibrinolytic activities, opens up new possibilities for their study in experimental and clinical trials. These natural compounds can be important complementary drugs for the recovery from hemostasis disorders due to their natural origin, safety, and low cost compared to synthetic drugs. In this review, the authors analyze possible pathophysiological mechanisms involved in the hemostasis disorders observed in the pathological progression of COVID-19, and also focus the attention of researchers on seaweed PSs as potential drugs aimed to correction these disorders in COVID-19 patients. Modern literature data on the anticoagulant, antithrombotic, and fibrinolytic activities of seaweed PSs are presented, depending on their structural features (content and position of sulfate groups on the main chain of PSs, molecular weight, monosaccharide composition and type of glycosidic bonds, the degree of PS chain branching, etc.). The mechanisms of PS action on the hemostasis system and the issues of oral bioavailability of PSs, important for their clinical use as oral anticoagulant and antithrombotic agents, are considered. The combination of the anticoagulant, thrombolytic, and fibrinolytic properties, along with low toxicity and relative cheapness of production, open up prospects for the clinical use of PSs as alternative sources of new anticoagulant and antithrombotic compounds. However, further investigation and clinical trials are needed to confirm their efficacy.

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Marine Bioprospecting

Dolui

2021

Bioprospecting of Plant Biodiversity for Industrial Molecules

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Effect of Sulfation on the Structure and Anticoagulant Activity of Ulvan Extracted From Green Seaweed Ulva Reticulata

Cited by 4 publications

References 6 publications

Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida

Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida

The Potency of Seaweed Sulfated Polysaccharides for the Correction of Hemostasis Disorders in COVID-19

Marine Bioprospecting

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