Effect of sulfate group on sulfated polysaccharides-induced improvement of metabolic syndrome and gut microbiota dysbiosis in high fat diet-fed mice

Wu, Shuang; Liu, Yili; Jiang, Pingrui; Xu, Yan; Zheng, Weiyun; Song, Shuang; Ai, Chunqing

doi:10.1016/j.ijbiomac.2020.08.010

Cited by 27 publications

(19 citation statements)

References 52 publications

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“…Most SPs are rich in sulfate (−2SO 3 ) groups, affording a wide pH range with negative charges that help them bind positively charged macromolecules, and coordinating water molecules to increase and maintain tissue hydration as well as facilitating an open extended solution conformation to reduce electrostatic repulsions between the negative charges (Caputo et al., 2019). Sulfated modification could significantly alter the structural characteristics of polysaccharides, increase their biological activity, as well as endow polysaccharides with new biological activities (Wang, Xie, et al., 2018; Wu et al., 2020). The position and degree of sulfation of SPs such as FUC and FCS could significantly affect their anticoagulant activity (Chen et al., 2011; Shang, Shan, et al., 2016; Shang, Yin, et al., 2016).…”

Section: Types Of Sps and Their Chemistrymentioning

confidence: 99%

“…According to the structural characters of SPs discussed in this review, these results also indicate that the glycosidic linkage type of SPs may mainly affect the diversity, composition, and metabolism of the gut microbiota (Shang, Shan, et al., 2016; Shang, Sun, et al., 2017). Nonetheless, the sulfation patterns and polymerization degrees may play a curial role in the modulation of SPs to affect the microbial ecology (Li, Li, Mao, Yan, et al., 2019; Shang, Sun, et al., 2017; Sun et al., 2019; Wu et al., 2020). Therefore, how intestinal microbiota utilize specific polysaccharides needs to be determined.…”

Section: Sps and Gut Microbiotamentioning

confidence: 99%

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Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Zhu

Han

Ding

et al. 2021

Comp Rev Food Sci Food Safe

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Various dietary sulfated polysaccharides (SPs) have been isolated from seafoods, including edible seaweeds and marine animals, and their health effects such as antiobesity and anti‐inflammatory activities have attracted remarkable interest. Sulfate groups have been shown to play important roles in the bioactivities of these polysaccharides. Recent in vitro and in vivo studies have suggested that the biological effects of dietary SPs are associated with the modulation of the gut microbiota. Dietary SPs could regulate the gut microbiota structure and, accordingly, affect the production of bioactive microbial metabolites. Because of their differential chemical structures, dietary SPs may specifically affect the growth of certain gut microbiota and associated metabolite production, which may contribute to variable health effects. This review summarizes the latest findings on the types and structural characteristics of SPs, the effects of different processing techniques on the structural characteristics and health effects of SPs, and the current understanding of the role of gut microbiota in the health effects of SPs. These findings might help in better understanding the mechanism of the health effects of SPs and provide a scientific basis for their application as functional food.

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Section: Types Of Sps and Their Chemistrymentioning

confidence: 99%

Section: Sps and Gut Microbiotamentioning

confidence: 99%

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Zhu

Han

Ding

et al. 2021

Comp Rev Food Sci Food Safe

Self Cite

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“…MSPs from abalone viscera also exhibited significantly hypolipidemic and anti-atherogenic activities [52]. Another abalone SP (AGSP) and its desulfated product D-AGSP can inhibit fat accumulation and improve lipid metabolism balance and gut microbiota dysbiosis in mice fed with high fat diet [94]. However, there were significant differences in relative abundance of Oscillibacter and Helicobacter in gut microbiota between AGSP and D-AGSP groups, and the butyrate content in feces of mice in D-AGSP group was significantly lower than that in AGSP group, indicating that the sulfate group did not have a decisive effect on the hypolipidemic activity of AGSP, but it might affect the inhibitory effect on metabolic syndrome by regulating the composition of gut microbiota and the expression of their metabolites [94].…”

Section: Role Of Sulfate Group and Sulphation Patternmentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.

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“…The glycosaminoglycan from Coelomactra antiquata showed high anticoagulant titer and fibrinolytic value [21]. The sulfated polysaccharides from pacific abalone improved the obesity induced by high fat diet in mice through gut microbiota mediated pathway [22].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide from Patinopecten yessoensis Skirt Boosts Immune Response via Modulation of Gut Microbiota and Short-Chain Fatty Acids Metabolism in Mice

Qin

Cheng

et al. 2021

Foods

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Polysaccharide from marine shellfish has various bioactivities. In this study, the effects of polysaccharide from Patinopecten yessoensis skirt (PS) on boosting immune response in mice were evaluated, and the potential mechanisms were explored. The results showed that PS administration effectively increased the serum IgG and IgM levels, implying that PS had immune response-boosting properties. Moreover, PS administration could modulate the composition of the gut microbiota, and significantly improve short-chain fatty acids (SCFAs) metabolism, especially butyrate metabolism. Of note, the expression of the Tlr2, Tlr7, MyD88, Tnfa, and Il1b genes in toll-like receptor (TLR) signaling pathway was significantly increased. In summary, PS could boost immune response by modulating the gut microbiota and SCFAs metabolism correlating with the activation of the TLR signaling pathway. Therefore, PS can be developed as a special ingredient for functional product.

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Effect of sulfate group on sulfated polysaccharides-induced improvement of metabolic syndrome and gut microbiota dysbiosis in high fat diet-fed mice

Cited by 27 publications

References 52 publications

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Polysaccharide from Patinopecten yessoensis Skirt Boosts Immune Response via Modulation of Gut Microbiota and Short-Chain Fatty Acids Metabolism in Mice

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