Effect of sucrose on the structure of a cubic phase formed from a monoolein/water mixture

Wang, Zhining; Zheng, Liqiang; Inoue, Tohru

doi:10.1016/j.jcis.2005.03.021

Cited by 23 publications

(15 citation statements)

References 21 publications

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“…Several authors have found that addition of drugs or solvents to GMO/water system have lead to modifications of the liquid crystalline structure,34–37 whilst others have shown no effect 38, 39. Caboi et al have investigated the effects of adding various hydrophilic and lipophilic compounds to the GMO/water system.…”

Section: Discussionmentioning

confidence: 99%

Liquid Crystalline Systems of Phytantriol and Glyceryl Monooleate Containing a Hydrophilic Protein: Characterisation, Swelling and Release Kinetics

Rizwan

Hanley

Boyd

et al. 2009

Journal of Pharmaceutical Sciences

115

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Section: Discussionmentioning

confidence: 99%

Liquid Crystalline Systems of Phytantriol and Glyceryl Monooleate Containing a Hydrophilic Protein: Characterisation, Swelling and Release Kinetics

Rizwan

Hanley

Boyd

et al. 2009

Journal of Pharmaceutical Sciences

115

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“…The plot generated a straight line passing through the origin for each of the three samples, which is the expected behavior for the cubic phase (31)(32)(33). The lattice parameters (α 0 ) of the cubic phase samples were calculated from the linear slope (2π/α 0 ) in Fig.…”

Section: Saxsmentioning

confidence: 98%

Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

et al. 2010

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Abstract. The purpose of this study was to design and investigate the transdermal controlled release cubic phase gels containing capsaicin using glycerol monooleate (MO), propylene glycol (1,2-propanediol, PG), and water. Three types of cubic phase gels were designed based on the ternary phase diagram of the MO-PG-water system, and their internal structures were confirmed by polarizing light microscopy (PLM) and small-angle X-ray scattering (SAXS). Release results showed the cubic phase gels could provide a sustained system for capsaicin, while the initial water content in the gels was the major factor affecting the release rate. Release kinetics was determined to fit Higuchi's square-root equation indicating that the release was under diffusion control. The calculated diffusion exponent showed the release from cubic phase gels was anomalous transport. The unique structure of the cubic phases, capsaicin distributed in the lipid bilayers, and cubic phase gel swelling contributed to the release mechanism. The cubic phase gel may be an interesting application for transdermal delivery system of capsaicin in alleviating the post-incision pain.

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“…Small angle X-ray scattering (SAXS) analysis, based on the synchrotron source, is a powerful tool to ascertain the phase characteristics of various LLC nanosystems within seconds, as compared to the timeframe of hours on the conventional laboratory SAXS instrument [8,[14][15][16]. It has enabled extensive investigations into the morphological stability and phase transition of LLC systems in water or phosphate buffer saline (PBS) across different environmental and biochemical parameters: Temperature [8,17], hydration state [17,18], ionic strength and biomacromolecule effects [15,[19][20][21][22], as well as pH [23][24][25]. However, their phase behaviour under physiological systemic conditions have been underexplored, to date.…”

Section: Introductionmentioning

confidence: 99%

Monocytic Cell-Induced Phase Transformation of Circulating Lipid-Based Liquid Crystalline Nanosystems

et al. 2020

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Both lamellar and non-lamellar configurations are naturally present in bio-membranes, and the synthetic lipid-based liquid crystalline nano-assemblies, mimicking these unique structures, (including liposomes, cubosomes and hexosomes) are applicable in the controlled delivery of bioactives. However, it remains uncertain whether these nanosystems retain their original phase identity upon contact with blood circulating cells. This study highlights a novel biological cell flow-through approach at the synchrotron-based small angle X-ray scattering facility (bio-SAXS) to unravel their real-time phase evolution when incubated with human monocytic cells (THP-1) in suspension. Phytantriol-based cubosomes were identified to undergo monocytic cell-induced phase transformation from cubic to hexagonal phase periodicity. On the contrary, hexosomes exhibited time-dependent growth of a swollen hexagonal phase (i.e., larger lattice parameters) without displaying alternative phase characteristics. Similarly, liposomes remained undetectable for any newly evolved phase identity. Consequently, this novel in situ bio-SAXS study concept is valuable in delivering new important insights into the bio-fates of various lipid-based nanosystems under simulated human systemic conditions.

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Effect of sucrose on the structure of a cubic phase formed from a monoolein/water mixture

Cited by 23 publications

References 21 publications

Liquid Crystalline Systems of Phytantriol and Glyceryl Monooleate Containing a Hydrophilic Protein: Characterisation, Swelling and Release Kinetics

Liquid Crystalline Systems of Phytantriol and Glyceryl Monooleate Containing a Hydrophilic Protein: Characterisation, Swelling and Release Kinetics

Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

Monocytic Cell-Induced Phase Transformation of Circulating Lipid-Based Liquid Crystalline Nanosystems

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