Effect of sucralfate on experimental colitis in the rat

Abstract

The therapeutic effect of sucralfate on ulcerated gastric and duodenal mucosa is well known. There is, however, almost no information about its activity in colitis. Experimental colitis was produced in rats by rectal instillation of 1 ml of 10 percent acetic acid, and 1.5 ml of a 20 percent suspension of sucralfate was then administered every 12 hours for various lengths of time. Study animals and appropriate controls were killed after 3, 7, 10, or 14 days. The distal colons were studied macroscopically and histologically. Colonic prostaglandin E2 levels were measured in animals killed after 3, 7, 10, or 14 days. The macroscopic score was significantly improved 10 and 14 days after induction of colitis, although the histologic appearance was unchanged. Acetic acid administration increased and sucralfate treatment reduced prostaglandin E2 levels in colitic animals on days 3 and 7, but not later. The present study supports a role for sucralfate in the treatment of colitis, but further studies on the mechanism of its effect and on its clinical activity are indicated.

Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis

“…Despite these aspects our findings were similar to those found by other authors who evaluated the effects of SCF on chemically-induced colitis model 41 . In the animals from the group where intervention was performed with saline, the epithelial surface was irregular, with a…”

Rectal bleeding and its management after irradiation for uterine cervical cancer

“…The laboratory findings on the biopsy specimen suggested that sucralfate acts as a scavenger of highly reactive oxygen metabolites and is the effective drug in reducing radiation-induced esophagitis. For the cytoprotective action of sucralfate, the following mechanisms were implicated (37)(38)(39)(40): protection of blood vessels, promotion of epithelial regeneration by protecting and stimulating the mucosal proliferation zone, and stimulation of growth factors such as epidermal growth factor. Kochhar et al (23,41) were the first to show good results in controlling rectal bleeding with rectally administered sucralfate.…”

Therapeutic Effect of Colloid Bismuth Subcitrate in Experimental Colitis in the Rat

“…Zahavi/Burg/Marcus/Karmeli/Nusinovitz/ De-Nol in Experimental Colitis Dinari Colonic prostaglandin levels are increased in active ulcerative colitis [16,17], and are decreased by therapeu tically effective drugs such as steroids, sulfasalazine, and sucralfate [21,22]. In the present study, CBS enemas sim ilarly reduced the elevated PGEr levels induced by acetic acid administration.…”

“…The morphologic features include multiple mucosal erosions and ulcers, accompa nied by severe inflammatory reaction and crypt abscesses, thus resembling human colitis [20,21], CBS enemas caused gross and histologic improvement in our animal model, evident even after a short treatment period of 5 days.…”