Effect of Substrates on Naproxen-Polyvinylpyrrolidone Solid Dispersions Formed via the Drop Printing Technique

Hsu, Hui‐Chin; Toth, Scott J.; Simpson, Garth J.; Taylor, Lynne S.; Harris, Michael T.

doi:10.1002/jps.23397

Cited by 41 publications

(25 citation statements)

References 38 publications

(65 reference statements)

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“…They found that the crystallization rate of aspirin on polymer surfaces was much slower when the polar surface energy component of the polymer surfaces decreased. However, Hsu et al showed the opposite effect of the influence of the polar surface energy of amorphous polymer surfaces on the crystallization behavior for a solid dispersion of Naproxen-PVP, that is, a lower polar surface energy of the polymer surface facilitated crystallization and vice versa [57]. The difference in the results in these two studies is probably a consequence of the difference in the lipophilic properties of the APIs used.…”

Section: 'Ink' Formulations and Substrate Choice In Printing Of Drug mentioning

confidence: 94%

“…When a drug is deposited on a solid substrate, for example, by printing, it is more prone to crystallization and the physical form of the drug would largely depend on parameters that govern heterogeneous crystallization processes. The physical form of the drug will thus be influenced by several factors, such as 'ink' formulation [44,46], the evaporation rate of the solvent [44], the drug--substrate interactions [55][56][57] and the substrate roughness [56] and porosity [55].…”

Section: 'Ink' Formulations and Substrate Choice In Printing Of Drug mentioning

confidence: 99%

See 1 more Smart Citation

Printing technologies in fabrication of drug delivery systems

Kolakovic

Ihalainen

Genina

et al. 2013

Expert Opinion on Drug Delivery

108

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It is evident that there is an urgent need to meet the challenges of rapidly growing trend of personalization of medicines through development of flexible drug-manufacturing approaches. In this context, various printing technologies, such as inkjet and flexography, can play an important role. Challenges on different levels exist and include: i) technological development of printers and production lines; ii) printable formulations and carrier substrates; iii) quality control and characterization; and iv) regulatory perspectives.

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Section: 'Ink' Formulations and Substrate Choice In Printing Of Drug mentioning

confidence: 94%

Section: 'Ink' Formulations and Substrate Choice In Printing Of Drug mentioning

confidence: 99%

Printing technologies in fabrication of drug delivery systems

Kolakovic

Ihalainen

Genina

et al. 2013

Expert Opinion on Drug Delivery

108

View full text Add to dashboard Cite

show abstract

“…In this case, the targeted polymorph was stabilised through refrigeration. It was found by Genina et al (2013b), and also Hirshfield et al (2014), that the recrystallisation behaviour of the API differed with the choice of printed surface and surface wettability, while Hsu et al (2013) reported the influence of surface microstructure. Crystallisation is also shown to be driven by the rate of evaporation after printing and the volatility of the carrier fluid (Hirshfield et al 2014).…”

Section: Deposition Influencesmentioning

confidence: 94%

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

263

185

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Abstract:Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

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“…It is also becoming evident that the nature of the substrate can determine the polymorphic form of any crystals produced as the solvent evaporates. For instance, Hsu et al (2013) noted that the substrate affected the crystallisation of naproxen when printed onto various solid amorphous dispersions while Buanz et al (2013) used ink-jet printing as a screening method for isolating pharmaceutical co-crystals.…”

Section: Substratesmentioning

confidence: 99%