Effect of Substituted Group of β-Cyclodextrin Derivatives on the Dispersing of Carbon Nanotubes

Bai, Yan; Xu, Gui Ying; Sun, Hong; Hao, Ai You; Mao, Hong Zhi; Dong, Shu Li; Shi, Xiaojie; Xin, Xia; Ao, Ming Qi; Pang, Jin Yu; Yang, Xiao

doi:10.1080/01932690903192945

Cited by 6 publications

(3 citation statements)

References 40 publications

(41 reference statements)

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“…This observed upshift in the G4-CNT-5 hydrogel may stem from strains induced by the adsorption of hydrogel constituents on the surface of the nanotubes, particularly cyclodextrins and G4s. Comparable Gband peaks shift values have been previously reported in pristine SWNTs when compared to SWNT/γ-cyclodextrin composites, 56 SWNT/substituted β-CD, 61,62 or SWNT/ β-CD polymer 63 systems, and were explained by either hydrophobic interactions with the polymer 63 or multiple van der Waals attraction forces between CD and the carbon nanomaterial.…”

Section: Preparation and Characterization Of Hydrogelssupporting

confidence: 67%

Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition

Sardaru,

Rosca,

Ursu

et al. 2024

ACS Omega

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Microbial infections represent a significant health risk, often leading to severe complications and, in some cases, even fatalities. As a result, there is an urgent need to explore innovative drug delivery systems and alternative therapeutic techniques. The photothermal therapy has emerged as a promising antibacterial approach and is the focus of this study. Herein, we report the successful synthesis of two distinct supramolecular composite hydrogels by incorporating graphene oxide (GO) and single-walled carbon nanotubes (SWNTs) into guanosine quadruplex (G4) based hydrogels containing covalently bound β-cyclodextrin (β-CD). The G4 matrix was synthesized through a two-step process, establishing a robust network between G4 and β-CDs, followed by the encapsulation of either GO or SWNTs. Comprehensive characterization of these composite hydrogels were conducted using analytical techniques, including circular dichroism, Raman spectroscopy, rheological investigations, X-ray diffraction, and scanning electron microscopy. A notable discovery from the conducted research is the differential photothermal responses exhibited by the hydrogels when exposed to near-infrared laser irradiation. Specifically, SWNT-based hydrogels demonstrated superior photothermal performance, achieving a remarkable temperature increase of up to 52 °C, in contrast to GO-based hydrogels, which reached a maximum of 34 °C. These composite hydrogels showed good cytotoxicity evaluation results and displayed synergistic antibacterial activity against Staphylococcus aureus, positioning them as promising candidates for antibacterial photothermic platforms, particularly in the context of wound treatment. This study offers a valuable contribution to the development of advanced and combined therapeutic strategies for combating microbial infections and highlights the potential of carbon nanomaterial-enhanced supramolecular hydrogels in photothermal therapy applications.

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Section: Preparation and Characterization Of Hydrogelssupporting

confidence: 67%

Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition

Sardaru,

Rosca,

Ursu

et al. 2024

ACS Omega

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“…β-CD with longer C-2 substituted group increases the hydrophilic character of the molecule and hence stronger surfactant action on drug/water contact angle is expected and higher dissolution rates are obtained. This could explain the better solubility results of hydroxy-butylated β-CD than hydroxy propylated form 28 .…”

Section: Resultsmentioning

confidence: 96%

Untitled

2013

IJPSR

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Oral bioavailability of Simvastatin is very low (5%) due to bad solubility and effect of first pass. The aim of this work is to enhance its solubility and reformulating it as orodispersible tablet to overcome the two problems. Simvastatin solid dispersions in βcyclodextrin, hydroxylpropylβ-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios namely 1:1, 1:2, and 1:3 by kneading and solvent evaporation methods. Solid dispersion formation and mixture compatibility was investigated by DSC and FTIR. Based on the results of solubility studies; the best solid dispersion formula was selected and formulated into orodispersible tablet using Emcosoy, K-polacrillin as novel superdisintegrants and mannitol, Pullulan as water soluble diluents and evaluated. The results showed that the increase in drug solubility was dependent on polymer type, concentration and also was affected by preparation method. Simvastatin-hydroxyl-butyl-β-cyclodextrin solid dispersion mixture prepared in 1:2 drug: polymer ratio by solvent evaporation method had a higher solubility. Orodispersible tablet formula prepared by Emcosoy as superdisintegrant, Pullulan as diluent showed least wetting and disintegration times (20 and 35 seconds respectively), faster water absorption rate (82), and the highest dissolution rate where the percentage of drug release reached 100% after 20 minutes.. In conclusion: Orodispersible tablets prepared by Emcosoy as superdisintegrant and pullulan as diluent containing simvastatin-hydroxybutyl-β-cyclodextrin is the best choice to improve its water solubility and hence its bioavailability. INTRODUCTION:Oral route is the simplest and most important way of drug administration, it offers advantages of convenience of administration and potential manufacturing cost savings 1 .

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“…A range of biomaterials consisting of n-decyl-β-Dmaltoside, ϒ-cyclodextrin, n-cyclodextrin, chitosan, pullulan, and phospholipid-dextran have been employed for noncovalent functionalization of CNTs (Braga et al 2014;Lu et al 2014;Ahmad et al 2013). They have assisted the process for the reason that such biomolecules have nearly no light adsorption in UV-Vis wavelength region, in order to that the CNTs polymeric composites can be characterized by photochemical and are mostly biocompatible and appropriate for many medicinal purposes Bai et al 2010;Krause et al 2010).…”

Section: Small Molecules Functionalized Cntsmentioning

confidence: 98%

Multifunctionalized Carbon Nanotubes Polymer Composites: Properties and Applications

Julkapli

Sapuan

2015

Advanced Structured Materials

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Carbon nanotubes (CNTs) is a rigid rod-like nanoscale material produced from carbon in powder, liquid, or gel form via acid or chemical hydrolysis. Due to its unique and exceptional renewability, biodegradability, mechanical, physicochemical properties, and abundance, the incorporation associated with a small quantity of CNTs to polymeric matrices enhance the mechanical and thermal resistance, and also stability of the latter by several orders of magnitude. Moreover, NCC-derived carbon materials are of no serious threat to the environment, providing further impetus for the development and applications of this green and renewable biomaterial for lightweight and degradable composites. Surface functionalization of CNTs remains the focus of CNTs research in tailoring its properties for dispersion in hydrophilic and hydrophobic media. Through functionalization, the attachment of appropriate chemical functionalities between conjugated sp 2 of CNTs and polymeric matrix is established. It is thus of utmost importance that the tools and protocols for imaging CNTs in a complex matrix and quantify its reinforcement, antimicrobial, stability, hydrophilicity, and biodegradability are be developed.

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Effect of Substituted Group of β-Cyclodextrin Derivatives on the Dispersing of Carbon Nanotubes

Cited by 6 publications

References 40 publications

Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition

Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition

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Multifunctionalized Carbon Nanotubes Polymer Composites: Properties and Applications

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