Effect of substituents on the ¹O₂ production and biological activity of (N^N^N)Pt(py) complexes

Abstract

Twelve (N^N^N)Platinum pyridyl complexes, (N^N^N)Pt(pyF), were synthesised and investigated for their singlet oxygen generation and potential biological activities. They exhibited 1IL and 1MLCT absorption transitions at approximately 325 and 360...

Photodynamic Effect of Amphiphilic N∧C∧N-Coordinated Platinum(II) Complexes in Human Umbilical Vein Endothelial Cells

“…The observed slight red shift in the MLCT band suggests that [Pt­(L)] + interacts with amino acids having aromatic rings in HSA. According to the literature, Pt­(II) complexes show a bathochromic shift due to the interaction of π electrons between the Pt­(II) complex and DNA nitrogenous bases when intercalated in DNA. In the CD spectra in Figure e, a positive signal in the 310–440 nm region corresponding to the MLCT absorption band of [Pt­(L)] + for X = 0.1–0.7 was observed along with the negative CD signal of HSA itself at around 300 nm (see also Figure S4).…”