Effect of suboptimal temperature on the regulation of endogenous antigen presentation in a rainbow trout hypodermal fibroblast cell line

Abram, Quinn H.; Rodríguez‐Ramos, Tania; Bols, Niels C.; Katzenback, Barbara A.; Dixon, Brian

doi:10.1016/j.dci.2019.103423

Cited by 12 publications

(2 citation statements)

References 68 publications

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“…A fibroblast cell line from a cold‐adapted teleost, the Arctic char ( Salvelinus alpinus ) expressed MHC I receptors at a temperature as low as 1°C and maintained resistance against viral infection (CSV, IPNV) at 4°C (Semple et al ., 2017). Similarly, in rainbow trout the endogenous antigen processing and presentation pathway (EAPP) for antiviral defence was still constitutively expressed at 4°C, but not inducible though (Abram et al ., 2019). In Atlantic salmon ( Salmo salar ) innate antiviral biomarker genes were strongly upregulated at 10.5°C compared to 16.5°C, in response to a viral mimic (polyriboinosinic polyribocytidylic acid – pIC) injection (Ignatz et al ., 2020).…”

Section: Teleost Immunity Is Modulated By Temperaturementioning

confidence: 99%

Temperature effects on teleost immunity in the light of climate change

Scharsack

Franke

2022

Journal of Fish Biology

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Temperature is an important environmental modulator of teleost immune activity. Susceptibility of teleosts to temperature variation depends on the species‐specific adaptive temperature range, and the activity of the teleost immune system is generally temperature‐dependent. Similar to many physiological and metabolic traits of ectotherms, temperature modulates the activity of immune traits. At low temperatures, acquired immunity of many teleost species is down‐modulated, and their immuno‐competence mainly depends on innate immunity. At intermediate temperatures, both innate and acquired immunity are fully active and provide optimal protection, including long‐lasting immunological memory. When temperatures increase and reach the upper permissive range, teleost immunity is compromised. Moreover, temperature shifts may have negative effects on teleost immune functions, in particular if shifts occur rapidly with high amplitudes. On the contrary, short‐term temperature increase may help teleost immunity to fight against pathogens transiently. A major challenge to teleosts therefore is to maintain immuno‐competence throughout the temperature range they are exposed to. Climate change coincides with rising temperatures, and more frequent and more extreme temperature shifts. Both are likely to influence the immuno‐competence of teleosts. Nonetheless, teleosts exist in habitats that differ substantially in temperature, ranging from below zero in the Arctic's to above 40°C in warm springs, illustrating their enormous potential to adapt to different temperature regimes. The present review seeks to discuss how changes in temperature variation, induced by climate change, might influence teleost immunity.

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Section: Teleost Immunity Is Modulated By Temperaturementioning

confidence: 99%

Temperature effects on teleost immunity in the light of climate change

Scharsack

Franke

2022

Journal of Fish Biology

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“…Upregulation of MHC class I and II APP and also of autophagy genes were observed after VHSV infection in rainbow trout RBCs [108,109]. Interestingly, suboptimal temperatures delayed the enhanced expression of MHC class I APP genes induced by VHSV infection in fibroblast cell lines derived from the rainbow trout [107] or the walleye (Sander vitreus) [106]. MHC class II upregulated through IFNγ overexpression was inhibited in a cell line of sea perch (Lateolabrax japonicus) after infection with VHSV [105].…”

Section: Modulation Of Antigen Processing and Presentation And Autoph...mentioning

confidence: 99%

Antigen Presentation and Autophagy in Teleost Adaptive Immunity

Johnstone

Chaves-Pozo

2022

IJMS

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Infectious diseases are a burden for aquaculture. Antigen processing and presentation (APP) to the immune effector cells that fight pathogens is key in the adaptive immune response. At the core of the adaptive immunity that appeared in lower vertebrates during evolution are the variable genes encoding the major histocompatibility complex (MHC). MHC class I molecules mainly present peptides processed in the cytosol by the proteasome and transported to the cell surface of all cells through secretory compartments. Professional antigen-presenting cells (pAPC) also express MHC class II molecules, which normally present peptides processed from exogenous antigens through lysosomal pathways. Autophagy is an intracellular self-degradation process that is conserved in all eukaryotes and is induced by starvation to contribute to cellular homeostasis. Self-digestion during autophagy mainly occurs by the fusion of autophagosomes, which engulf portions of cytosol and fuse with lysosomes (macroautophagy) or assisted by chaperones (chaperone-mediated autophagy, CMA) that deliver proteins to lysosomes. Thus, during self-degradation, antigens can be processed to be presented by the MHC to immune effector cells, thus, linking autophagy to APP. This review is focused on the essential components of the APP that are conserved in teleost fish and the increasing evidence related to the modulation of APP and autophagy during pathogen infection.

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