Effect of Sublethal X-Irradiation of Guinea Pigs on Vaccinall Tularemia Infection,

Abstract

To delineate dfifrenL:es in the resistanca of irradiated and nonirradLatod animals to live tularemia vAccines, the chronological appearance and growth rate of LVS in the lung, liver, spleen, and blood of guinea pigs were studied. Nonlcradlaced controls and guinea pigs having received 140 R three days previoualy were exposed via the rizp'rttory route to.: 1.0 cells of LVS and sacrificed at Intervals from one to 21 days, No major difference* were noted in the time of spprarance, growth rate, zaximust organissm content, or time o: clearance of LVS from the tissues of Irradiated and nonirradis•td animals;