Effect of sublethal hexavalent chromium exposure on the pituitary‐ovarian axis of a teleost, <i>Channa punctatus</i> (Bloch)

Mishra, Ashish; Mohanty, Bishnupad

doi:10.1002/tox.20654

Cited by 14 publications

(10 citation statements)

References 44 publications

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“…The involvement of oxidative stress in heavy metal toxicity is known. CrVI exposure-induced impairment of the pituitary-ovarian axes in Teleost, Channa punctatus (Bloch) was reported (Mishra and Mohanty, 2012). CrVIinduced oxidative stress in mouse (Rao et al, 2009) and rat ovary (Samuel et al, 2012) and uterus (Samuel et al, 2011b) were known.…”

Section: Discussionmentioning

confidence: 99%

Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring

Samuel

Stanley

Sekar

et al. 2012

Environmental Toxicology

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Hexavalent chromium (CrVI) is a highly toxic metal and a major environmental pollutant. Several studies indicate that CrVI exposure adversely affects reproductive function. We reported that maternal Cr exposure resulted in Cr accumulation in the reproductive organs of female offsprings. CrVI can cross the placental barrier and also can be passed through breastfeeding. The present investigation aimed to determine the persistent (in utero through puberal period) CrVI exposure-induced toxic effects on the reproductive functions of mother and the offspring. Induction of oxidative stress is one of the plausible mechanisms behind Cr-induced cellular deteriorations. Mother rats exposed to CrVI showed reduced reproductive outcome, while the offsprings showed higher accumulation of Cr in ovary, altered steroid, and peptide hormones. Specific activities of antioxidant enzymes were decreased and associated with increased levels of H2 O2 , and lipid peroxidation. CrVI exposure also damaged the ovarian histoarchitecture in various age groups studied. CrVI exposure also delayed the sexual maturation. Results from the present investigation suggest that CrVI exposure from in utero through puberal period significantly damaged the pubertal development through altered antioxidants, anemia, and altered hormone levels. These changes were associated with damaged ovarian histoarchitecture and extended estrous cycle in developing Wistar rats.

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Section: Discussionmentioning

confidence: 99%

Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring

Samuel

Stanley

Sekar

et al. 2012

Environmental Toxicology

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“…The pituitary-thyroid axis is one of the three major endocrine axes of teleosts which play important roles in a number of physiological and metabolic processes (Vijayan and Moon, 1992;Blanton and Specker, 2007;Carr and Patino, 2011). Although hexavalent chromium exposureinduced impact on the pituitary-ovarian (Mishra and Mohanty, 2012a, b) and pituitary-interrenal (Mishra and Mohanty, 2009a, b) axes have been demonstrated, effect on pituitary-thyroid axis has not been well reported. Teles et al (2005) have reported the effect of Cr(VI) exposure in BNF (PAH-like compound)-pretreated European eel, but effective dose level was not specified.…”

Section: Discussionmentioning

confidence: 99%

Effect of acute hexavalent chromium exposure on pituitary–thyroid axis of a freshwater fish, Channa punctatus (Bloch)

Mishra

Mohanty

2013

Environmental Toxicology

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Acute exposure to hexavalent chromium (10 mg L(-1) , 20 mg L(-1) , and 40 mg L(-1) potassium dichromate for 96 h) dose-dependently affected the pituitary-thyroid axis of teleost, Channa punctatus. Significant hypertrophy of the thyroid follicle was observed in 20 mg L(-1) and 40 mg L(-1) groups; the follicular epithelium was however hypertrophied only in 40 mg L(-1) group. The colloid depletion in the lumen of thyroid follicle was evident in 20 mg L(-1) and 40 mg L(-1) groups. Serum thyroid hormones (thyroxine/T4 and triiodothyronine/T3) level increased significantly at both the higher doses. Increased immunointensity and significant hypertrophy of the pituitary thyrotrophs (anti TSHβ-immunoreactive cells) was observed in both 20 mg L(-1) and 40 mg L(-1) chromium-exposed fish. The increased thyroid hormones secretion observed in this study might be an adaptive response of the pituitary-thyroid axis under acute chromium-induced stress condition to maintain homeostasis. The long-term Cr(VI) exposures, however, may lead to attenuation/exhaustion of the pituitary-thyroid axis and pose serious threat to fish health and affect their population.

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“…It is easily reduced to Cr(III) and during these transformations, reactive oxygen species (ROS) and reactive nitrogen species (RNS), which have an indisputable role in carcinogenesis, can be formed [21][22][23]. However, chromium is recognized as a metalloestrogen; there are only a few reports in the available literature on chromium/estrogen interaction [24][25][26]. There is no information about the role of estradiol metabolites in exposure to chromium in cancerogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Interaction between 17β-Estradiol, 2-Methoxyestradiol and 16α-Hydroxyestrone with Chromium (VI) on Ovary Cancer Line SKOV-3: Preliminary Study

et al. 2020

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Ovarian cancer is the leading cause of death from gynecologic malignancies. Some estrogens, as well as xenoestrogens, such as chromium (VI) (Cr(VI)), are indicated as important pathogenic agents. The objective of this study was to evaluate the role of estradiol and some its metabolites upon exposure to the metalloestrogen Cr(VI) in an in vitro model. The changes in cell viability of malignant ovarian cancer cells (SKOV-3 resistant to cisplatin) exposed to 17β-estradiol (E2) and its two metabolites, 2-methoxyestradiol (2-MeOE2) and 16α-hydroxyestrone (16α-OHE1), upon exposure to potassium chromate (VI) and its interactions were examined. The single and mixed models of action, during short and long times of incubation with estrogens, were applied. The different effects (synergism and antagonism) of estrogens on cell viability in the presence of Cr(VI) was observed. E2 and 16α-OHE1 caused a synergistic effect after exposure to Cr(VI). 2-MeOE2 showed an antagonistic effect on Cr(VI). The examined estrogens could be ranked according to the most protective effect or least toxicity in the order: 2-MeOE2 > E2 > 16α-OHE1. Early pre-incubation (24 h or 7 days) of cells with estrogens caused mostly an antagonistic effect—protective against the toxic action of Cr(VI). The beneficial action of estrogens on the toxic effect of Cr(VI), in the context of the risk of ovarian cancer, seems to be important and further studies are needed.

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Effect of sublethal hexavalent chromium exposure on the pituitary‐ovarian axis of a teleost, Channa punctatus (Bloch)

Cited by 14 publications

References 44 publications

Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring

Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring

Effect of acute hexavalent chromium exposure on pituitary–thyroid axis of a freshwater fish, Channa punctatus (Bloch)

Effect of Interaction between 17β-Estradiol, 2-Methoxyestradiol and 16α-Hydroxyestrone with Chromium (VI) on Ovary Cancer Line SKOV-3: Preliminary Study

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