Effect of sub‐lethal treatment of carvacrol and thymol on virulence potential and resistance to several bactericidal treatments of <scp><i>Staphylococcus aureus</i></scp>

Kim, Yu‐Min; Shin, Minjung; Kang, Jun‐Won; Kang, Dong‐Hyun

doi:10.1111/jfs.13004

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…Camphor is a white crystalline solid material with a strong aroma usually obtained from the bark of the Cinnamomum camphora tree through distilling [ 12 ]. Camphor exhibits potent antibacterial properties against various bacteria, including Streptococcus mutants , Enterococcus faecalis , and S. aureus [ 13 , 14 ]. This terpenoid has been used as an antiseptic, culinary spice, cold treatment, and aphrodisiac [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Abdollahi,

Fereydouni,

Moradi

et al. 2024

BMC Complement Med Ther

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Herbal components are highly useful assets for the advancement of novel antibacterial drugs. Nanotechnology holds great promise as an approach to enhance the effectiveness and develop the composition of these substances. The study developed nanogels incorporating camphor, thymol, and a combination derived from the initial nanoemulsions with particle sizes of 103, 85, and 135 nm, respectively. The viscosity of nanogels and the successful loading of compounds in them were examined by viscometery and ATR-FTIR studies. The bactericidal properties of the nanogels were examined against four bacterial strains. The nanogel containing camphor and thymol at 1250 µg/mL concentration exhibited complete growth suppression against Pseudomonas aeruginosa and Staphylococcus aureus. The thymol nanogel at 1250 µg/mL and the camphor nanogel at 2500 µg/mL exhibited complete inhibition of growth on Listeria monocytogenes and Escherichia coli, respectively. Both nanogels showed favorable effectiveness as antibacterial agents and could potentially examine a wide range of pathogens and in vivo studies.

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Section: Introductionmentioning

confidence: 99%

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Abdollahi,

Fereydouni,

Moradi

et al. 2024

BMC Complement Med Ther

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Potential Anti-Infectious Activity of Essential Oil Chemotypes of Lippia origanoides Kunth on Antibiotic-Resistant Staphylococcus aureus Strains

Uc-Cachón,

Calvo-Irabien,

Dzul-Beh

et al. 2024

Plants

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Staphylococcus aureus infections are prevalent in healthcare and community environments. Methicillin-resistant S. aureus is catalogued as a superbug of high priority among the pathogens. This Gram-positive coccus can form biofilms and produce toxins, leading to persistent infection and antibiotic resistance. Limited effective antibiotics have encouraged the development of innovative strategies, with a particular emphasis on resistance mechanisms and/or virulence factors. Medicinal aromatic plants have emerged as promising alternative sources. This study investigated the antimicrobial, antibiofilm, and antihemolysis properties of three different chemotypes of Lippia origanoides essential oil (EO) against susceptible and drug-resistant S. aureus strains. The chemical composition of the EO was analyzed using GC-MS, revealing high monoterpene concentrations, with carvacrol and thymol as the major components in two of the chemotypes. The third chemotype consisted mainly of the sesquiterpene β-caryophyllene. The MIC values for the two monoterpene chemotypes ranged from 62.5 to 500 µg/mL for all strains, whereas the sesquiterpene chemotype showed activity against seven strains at concentrations of 125–500 µg/mL, which is the first report of its anti-S. aureus activity. The phenolic chemotypes inhibited biofilm formation in seven S. aureus strains, whereas the sesquiterpene chemotype only inhibited biofilm formation in four strains. In addition, phenolic chemotypes displayed antihemolysis activity, with IC50 values ranging from 58.9 ± 3.8 to 128.3 ± 9.2 µg/mL. Our study highlights the importance of L. origanoides EO from the Yucatan Peninsula, which has the potential for the development of anti-S. aureus agents.

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Effect of sub‐lethal treatment of carvacrol and thymol on virulence potential and resistance to several bactericidal treatments of Staphylococcus aureus

Cited by 2 publications

References 62 publications

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

Potential Anti-Infectious Activity of Essential Oil Chemotypes of Lippia origanoides Kunth on Antibiotic-Resistant Staphylococcus aureus Strains

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