Effect of styrene exposure on plasma parameters, molecular mechanisms and gene expression in rat model islet cells

Niaz, Kamal; Hassan, Fatima; Mabqool, Faheem; Khan, Fazlullah; Momtaz, Saeideh; Baeeri, Maryam; Navaei-Nigjeh, Mona; Rahimifard, Mahban; Abdollahi, Mohammad

doi:10.1016/j.etap.2017.06.020

Cited by 31 publications

(10 citation statements)

References 70 publications

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“…The absorption of chemical solvents and active metabolic intermediates can increase oxidative stress and cytokine levels, leading to changes in glucose metabolism and inducing IR [28]. Animal experimental evidence also shows that oxidative stress, in ammatory factors, cell viability, and glucose-metabolism-related genes are sensitive to styrene [29].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Gut Microbiota and Its Relationship With Serum Sex Hormones in Non-obese Polycystic Ovary Syndrome Patients With Insulin Resistance

Cai¹,

Ni²,

Yao³

et al. 2022

Preprint

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Background: Insulin resistance (IR) is a common symptom in obese polycystic ovary syndrome (PCOS) patients, as well as in non-obese PCOS patients. Gut microbiota is closely related to IR. However, the relationship between gut microbiota and IR remains unclear in non-obese PCOS patients. Objective: To analyze the composition of the gut microbiota population in non-obese PCOS-IR patients compared to PCOS alone and healthy women. Methods: In the present study, fecal samples from non-obese PCOS patients with and without IR and healthy women were analyzed by 16S rRNA gene sequencing. Moreover, serum hormone levels were detected on the third day of menstruation, and the correlation between gut microbiota and serum hormone was analyzed using R language.Results: We found that the gut microbiota character differed in each group, and the gut microbiota abundance of PCOS-IR group was remarkably reduced.The abundance of Ruminococcaceae_UCG-004 and Acetanaerobacterium in the PCOS-IR group was significantly lower than that of the PCOS-NIR group. Furthermore, the comparison between PCOS-IR and control group revealed that g__Fusobacterium and g__Faecalibaculum were the unique genus of the PCOS-IR group. Moreover, the relationship between gut microbiota, IR, and serum sex hormones was determined. In PCOS with IR group, the relationship between gut microbiota and androgen was more significant. In PCOS without IR group, the relationship between gut microbiota and androgen was no significant. Its mechanism may be related to the different abundance in enzymes (futalosine hydrolase, arogenate dehydrogenase (NADP(+), and L-lysine 6-transaminase) and metabolic pathways (isoquinoline alkaloid biosynthesis, styrene degradation, and atrazine degradation), but it needs to be further explored in subsequent experiments. Conclusion: The gut microbiota composition of non-obese PCOS patients with insulin resistance is different from that of PCOS alone and healthy women. The difference is correlated with the clinical characteristics of PCOS, with regards to insulin resistance and sex hormone. The abnormality of gut microbiota may lead to the occurrence and development of PCOS-IR. All in all, this study not only provided supplements for the existing studies, but also revealed the potential pathogenic bacteria genus, thus providing a new idea for the treatment of PCOS with IR.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Gut Microbiota and Its Relationship With Serum Sex Hormones in Non-obese Polycystic Ovary Syndrome Patients With Insulin Resistance

Cai¹,

Ni²,

Yao³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…It has been reported that the use of doxorubicin increases the ROS level of cardiac cells, and subsequently, they are able to attack the cell macromolecules, leading to malfunction of the heart tissue [ 35 , 38 , 50 , 59 ]. Upon mitochondrial injury, the generation of free radicals in the cells elevates [ 81 ]; in this regard, doxorubicin through impairment of mitochondrial malfunction can increase the generated free radicals [ 35 ]. This chemotherapeutic agent also increases lipid peroxidation (LPO) markers of MDA and TBARS in the heart tissue, leading to the cell membrane devastation and malfunction [ 41 , 46 , 47 , 49 , 53 – 55 , 58 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin‐Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti‐Inflammatory Activities

Lan

et al. 2021

Oxidative Medicine and Cellular Longevity

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Purpose. Although doxorubicin chemotherapeutic drug is commonly used to treat various solid and hematological tumors, its clinical use is restricted because of its adverse effects on the normal cells/tissues, especially cardiotoxicity. The use of resveratrol may mitigate the doxorubicin-induced cardiotoxic effects. For this aim, we systematically reviewed the potential chemoprotective effects of resveratrol against the doxorubicin-induced cardiotoxicity. Methods. In the current study, a systematic search was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline for the identification of all relevant studies on “the role of resveratrol on doxorubicin-induced cardiotoxicity” in the electronic databases of Web of Science, PubMed, and Scopus up to March 2021 using search terms in their titles and abstracts. Two hundred and eighteen articles were screened in accordance with a predefined set of inclusion and exclusion criteria. Finally, 33 eligible articles were included in this systematic review. Results. The in vitro and in vivo findings demonstrated a decreased cell survival, increased mortality, decreased heart weight, and increased ascites in the doxorubicin-treated groups compared to the control groups. The combined treatment of resveratrol and doxorubicin showed an opposite pattern than the doxorubicin-treated groups alone. Furthermore, this chemotherapeutic agent induced the biochemical and histopathological changes on the cardiac cells/tissue; however, the results (for most of the cases) revealed that these alterations induced by doxorubicin were reversed near to normal levels (control groups) by resveratrol coadministration. Conclusion. The results of this systematic review stated that coadministration of resveratrol alleviates the doxorubicin-induced cardiotoxicity. Resveratrol exerts these chemoprotective effects through several main mechanisms of antioxidant, antiapoptosis, and anti-inflammatory.

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“…e ROS attacks the cell macromolecules and leads to malfunction of the heart tissue [2,56,57,64]. It also showed that upon mitochondrial damage, the generation of free radicals increases in the cells [82]; in this regard, doxorubicin through impairment of mitochondrial function can elevate the generation of free radicals [2,64,83]. Moreover, this chemotherapeutic agent is able to increase Figure 2: molecular mechanisms of cardiac adverse effects mediated by doxorubicin.…”

Section: Antioxidant Actionsmentioning

confidence: 99%

In Vitro and In Vivo Cardioprotective Effects of Curcumin against Doxorubicin-Induced Cardiotoxicity: A Systematic Review

Zhang

Wu²

2022

Journal of Oncology

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Objective. This study aimed to review the potential chemoprotective effects of curcumin against the doxorubicin-induced cardiotoxicity. Methods. According to the PRISMA guideline, a comprehensive systematic search was performed in different electronic databases (Web of Science, PubMed, and Scopus) up to July 2021. One hundred and sixty-four studies were screened in accordance with a predefined set of inclusion and exclusion criteria. Eighteen eligible articles were finally included in the current systematic review. Results. According to the in vitro and in vivo findings, it was found that doxorubicin administration leads to decreased cell survival, increased mortality, decreased bodyweight, heart weight, and heart to the bodyweight ratio compared to the control groups. However, curcumin cotreatment demonstrated an opposite pattern in comparison with the doxorubicin-treated groups alone. Other findings showed that doxorubicin significantly induces biochemical changes in the cardiac cells/tissue. Furthermore, the histological changes on the cardiac tissue were observed following doxorubicin treatment. Nevertheless, for most of the cases, these biochemical and histological changes mediated by doxorubicin were reversed near to control groups following curcumin coadministration. Conclusion. It can be mentioned that coadministration of curcumin alleviates the doxorubicin-induced cardiotoxicity. Curcumin exerts these cardioprotective effects through different mechanisms of antioxidant, antiapoptosis, and anti-inflammatory. Since the finding presented in this systematic review are based on in vitro and in vivo studies, suggesting the use of curcumin in cancer patients as a cardioprotector agent against cardiotoxicity mediated by doxorubicin requires further clinical studies.

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Effect of styrene exposure on plasma parameters, molecular mechanisms and gene expression in rat model islet cells

Cited by 31 publications

References 70 publications

Characteristics of Gut Microbiota and Its Relationship With Serum Sex Hormones in Non-obese Polycystic Ovary Syndrome Patients With Insulin Resistance

Characteristics of Gut Microbiota and Its Relationship With Serum Sex Hormones in Non-obese Polycystic Ovary Syndrome Patients With Insulin Resistance

A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin‐Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti‐Inflammatory Activities

In Vitro and In Vivo Cardioprotective Effects of Curcumin against Doxorubicin-Induced Cardiotoxicity: A Systematic Review

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