Effect of structured physical activity and nutritional supplementation on physical function in mobility-limited older adults: Results from the VIVE2 randomized trial

Abstract

Results suggest improved gait speed following physical activity program with no further improvement with added nutritional supplementation.

Lifestyle Interventions with a Focus on Nutritional Strategies to Increase Cardiorespiratory Fitness in Chronic Obstructive Pulmonary Disease, Heart Failure, Obesity, Sarcopenia, and Frailty

“…While the supplement group experienced greater declines in intramuscular fat measured by computed tomography than the placebo group, both groups had similar decreases in total body FM on DEXA scan and gains in muscular strength [95]. There were also improvements in both groups in the 400 m walk test, but no between-group differences were observed [142].…”

Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention

“…At 6 months, both groups improved significantly in gait speed on the 400-m walk, with an average increase of 0.08 m/ second in the intervention group and an increase of 0.11 m/second in the placebo group. 61 There was no significant difference between the 2 groups. Similarly, SPPB scores significantly improved in both groups (by 2.1 points in the intervention group and by 2.6 points in the placebo group), with no significant difference between the groups.…”

“…VIVE2 (Vitality, Independence, and Vigor Study) recently examined the effect of a 6-month exercise intervention as well as a nutritional supplement consisting of both protein and vitamin D on lower extremity function, body composition, and muscle strength and quality. 60,61 Participants (N ¼ 149) who were enrolled were similar to those who participated in the LIFE study in that they were mobility limited (SPPB score 9). In addition, all subjects had vitamin D levels between 9 and 24 ng/mL at baseline.…”

Efeito do treinamento de força em associação à suplementação de proteína e creatina sobre a composição corporal, força e funcionalidade de idosos frágeis e pré-frágeis

“…74,3%; WCr: 71,5%). Na maioria dos estudos com idosos a aderência fica entre 72-100% (FIATARONE et al, 1994;CANDOW et al, 2008;TIELAND et al, 2012;CHALE et al, 2013;DALY et al, 2014;VILLANUEVA et al, 2014;RONDANELLI et al, 2016;COLLINS et al, 2016;BELL et al, 2017;FIELDING et al, 2017 VOLPI et al, 2013;VALENZUELA et al, 2013); a segunda, visando facilitar ao idoso adicionar à sua dieta uma grande quantidade de proteína e, assim, aumentar consideravelmente a ingestão diária total desse nutriente. Nos estudos que se tem disponíveis é possível observar uma grande variedade de protocolos de suplementação, alguns com esse mesmo propósito de explorar as diversas doses ao longo do dia e outras apenas incluindo uma dose diária para aumentar a ingestão total.…”

“…Nesse caso, as duas hipóteses anteriormente citadas se mostram sem fundamento, uma vez que o consumo habitual de proteína dos idosos nesses estudos já era alto e após a suplementação não foram atingidos valores médios maiores do que o que se pode observar em vários estudos que não obtiveram benefícios da suplementação (KUKULJAN et al, 2009;LEENDERS et al, 2013;MALTAIS et al, 2016). (RONDANELLI et al, 2016;FIELDING et al, 2017, principalmente com os idosos institucionalizados e mais fragilizados (FREIBERGER et al, 2016).…”