Effect of strontium surface-functionalized implants on early and late osseointegration: A histological, spectrometric and tomographic evaluation

Abstract

This study presents first data with respect to early and late in vivo response on a strontium functionalized titanium surface comprising a nanotopography manufactured by a magnetron sputtering process. We investigated different osseointegration stages of screw-shaped implants with dental implant geometries in a rabbit femur model observing beneficial effects of the functionalized surface on bone-to-implant contact and bone formation caused by tailored release of the bone anabolic strontium. Histomorphometrical data revealed that a functionalized titanium surface with controlled liberation of strontium accelerates osseointegration while spectrometry measurements did not indicate a potential systemic effect of this osteoinductive agent and could thus have impact on modifications of medical implant devices.

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

“…Strontium can incorporate into ion exchange during bone remodeling via similarity in the size and behavior to calcium ions, which allows Sr to affect some osteoblast mediated processes by activating calcium sensing receptors (CaSR) in osteoblasts and stimulating the expression of local growth factors [3]. Increase of Sr ions around the CPC reduces crystallinity and alters the crystal lattices, improving solubility of biomaterial [50].…”

“…In the field of orthopedics, an osteoporotic femoral neck fracture is one of the most common and devastating injuries and, despite correct surgical fixation, avascular necrosis or metal implant dislocations can occur in up to 22.5% of bone surgery cases [2]. To overcome those complications, many attempts have been made to improve bone healing and mechanical stability of the prosthesis by creating physiologically active implant induced bone remodeling [3]. Bone tissue engineering (BTE) is a promising approach for treating bone defects by providing a template to guide bone regeneration [4].…”

Histological and Bone Morphometric Evaluation of Osseointegration Aspects by Alkali Hydrothermally-Treated Implants

“…Several studies have shown that titanium surface topography can be improved by various modification methods, including grit blasting, acid etching, alkali, strontium or magnesium hydrothermal treatment, and other methods [5][6][7][8][9][10]. Modification of the titanium surface enhances osteoblast activity and increases the area of contact between the implant and surrounding bone, thus facilitating osseointegration [5].…”

Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

“…Subsequently, the sections were stained with Stevenel's blue and VG staining 11b. ROIs were determined as ROI‐I <0 μm (inside the implant), ROI‐II 0–250 μm (outside the implant), and ROI‐III 250–500 μm (outside the implant) . Image J (NIH, Bethesda, USA) was used for related qualitative analysis.…”