Effect of strontium ions on the growth of ROS17/2.8 cells on porous calcium polyphosphate scaffolds

Qiu, Kai; Zhao, Xizeng; Wan, Chang; Zhao, Chang; Chen, Yuan Wei

doi:10.1016/j.biomaterials.2005.08.006

Cited by 193 publications

(159 citation statements)

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“…19), 20) Xue et al prepared a strontium-containing apatite and evaluated its abilities for the cell adhesion, proliferation and differentiation; the strontium-containing apatite was superior in the ability of cell adhesion in comparison with a conventional apatite. The numbers of the cells on the strontium-containing apatite and the conventional one, after 14 d of culturing were 15 and 9 times higher than those on each sample after 3 d of culturing, respectively.…”

Section: +mentioning

confidence: 99%

“…The proliferation of osteoblast-like clonal cell line (ROS17/2.8) and ALP expression were much better on the calcium polyphosphate substituted with < 20 mol% strontium than on the unsubstituted one. 20) Strontium-containing biodegradable materials, which can release Sr 2+ ions slowly, may enhance bone formation through the stimulation of cell functions by the ions. Glasses and glassceramics are expected to be useful in the preparation of the materials.…”

Section: +mentioning

confidence: 99%

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Ion release from SrO-CaO-TiO2-P2O5 glasses in Tris buffer solution

Lee

Obata

Kasuga

2009

J. Ceram. Soc. Japan

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SrO-containing calcium phosphate invert glasses, (60-x)CaO•xSrO•30P2O5•7Na2O•3TiO2 (mol%, x = 0 -60), which are expected to inhibit bone resorption by osteoclast and enhance bone formation, were prepared and their ion release behaviors in Tris buffer solution were estimated. The glass containing 20 mol% of SrO showed the smallest amount of the dissolved ions in the present work. Laser Raman spectra showed that the peaks of phosphate groups and TiOy polyhedral groups red-shifted with increasing the SrO content in the glasses. The shift was suggested to be due to decrease in bonding strength between cations and phosphate groups or TiOy polyhedral groups in the glasses. In the case of the glasses containing SrO over 20 mol%, no shifts of Raman peaks due to the TiOy polyhedra were observed. The TiOy (y = 4 or 6) polyhedra in the glasses can coordinate with cations up to 18 mol% since they contain 3 mol% of TiO2. Sr 2+ ions are supposed from the shift behavior of the Raman peaks to preferentially coordinate with the TiOy polyhedra; the formation of this structure would induce decrease in the ion amounts released from the glasses containing 0 -20 mol% of SrO.

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Section: +mentioning

confidence: 99%

Section: +mentioning

confidence: 99%

Ion release from SrO-CaO-TiO2-P2O5 glasses in Tris buffer solution

Lee

Obata

Kasuga

2009

J. Ceram. Soc. Japan

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“…As was previously reported, Sr ions have been shown to enhance bone collagen synthesis and decrease bone resorption by inhibiting osteoclast resorbing activity [13][14][15][16][17][18][19][20] . Therefore, it is expected that a local release of Sr ions from implant surfaces would directly improve implant osseointegration.…”

Section: Introductionmentioning

confidence: 99%

Effect of strontium ions on calcification of preosteoblasts cultured on porous calcium- and phosphate-containing titanium oxide layers formed by micro-arc oxidation

et al. 2016

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INTRODUCTIONTitanium (Ti) and its alloys have been used in dentistry as implant materials because of their good mechanical properties, high corrosion resistance, and low cytotoxicity. However, their poor bone fusion properties limit their clinical applications 1) . Various techniques have been explored to modify the surfaces of Ti and its alloys to improve their osseointegration, including plasma spraying, sol-gel method, and electrochemical deposition [2][3][4][5][6][7][8][9][10][11][12] . Among these modification methods, micro-arc oxidation (MAO) has attracted special attention since it is a relatively convenient and effective technique for depositing oxide coatings on the surfaces of nonferrous metals [9][10][11][12] . More importantly, by using this technique, various desired elements can be introduced into the coated layers with porous structures 11) , such as calcium (Ca), phosphorus (P), magnesium (Mg) and strontium (Sr), which are trace elements in the human body playing a significant role in bone formation.Sr is considered a bioactive element that improves implant osseointegration. As was previously reported, Sr ions have been shown to enhance bone collagen synthesis and decrease bone resorption by inhibiting osteoclast resorbing activity [13][14][15][16][17][18][19][20] . Therefore, it is expected that a local release of Sr ions from implant surfaces would directly improve implant osseointegration.Since our previous studies have shown that MAO is a promising method to produce porous and firmly adherent bone formation concerned elements contained oxide deposition layers on metal substrates 11) , it is easy to optimize the Sr amounts introduced into the oxide deposition layers by altering MAO electrolyte compositions. Moreover, except for the first several days, a long-term stable release of metallic ions from the oxide deposition layers can be achieved by using the microporous structures formed during the MAO process 8) . In this study, Ti surfaces were modified by MAO using electrolytes with different Sr concentrations to promote calcification of preosteoblasts. Morphologies and elemental compositions of the surfaces as well as cross-sections of the Ti specimens obtained with and without MAO were characterized by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). A mouse preosteoblast MC3T3-E1 was utilized to study the calcification effect of Sr contents in the MAO-deposited layers on the Ti substrates in vitro. Osteogenic differentiation and calcified depositions of the MC3T3-E1 cells cultured on all specimens were evaluated using alkaline phosphatase (ALP) activity assay and alizarin red s staining, respectively. MATERIALS AND METHODS Ti substrate preparationCommercially pure Ti discs (grade 2, 8 mmφ×2.0 mm in thickness, Rare Metallic, Tokyo, Japan) were used in this study. Before the MAO treatment, Ti discs were mechanically polished with up to #800-grid SiC abrasive paper and then ultrasonically rinsed in acetone and ethanol. The obtained specimens (not subjected to...

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“…Sr 2+ ions are able to impact bonerelated cells and induce osteoblast activity by stimulating bone formation and reducing bone resorption 63) . For this reason, Mg and Sr have been incorporated into biomaterials to further improve their bioactivity for bone-regeneration applications 64,65) . They can be substituted instead of calcium in BGNs for better bone remodeling and osseosysthesis stimulation and iondoped BGNs promoted osteoblast proliferation while also decreasing in the osteoclast activity 66,67) .…”

Section: Beneficial Effects Of Bioactive Glass Nanocomposites On Dentmentioning

confidence: 99%

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

2016

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Bioactive glass nanoparticles (BGNs) have been used over a range of dental tissue engineering. One main reason is possibly that BGNs strongly interact with hard tissues, while forming a stable interface after implantation. Recently, BGNs have been further diversified and ameliorated by incorporating bio-functional ions into BGNs or by functionally modifying the surface of BGNs. A comprehensive overview of the processes and applications of BGNs and their derivatives for the use in dentistry is thus necessary for their stepforward. Therefore, this review focuses on a variety of processes and practical applications of BGNs and their derivatives, which is expected to aid readerships with understanding and employing BGNs and their derivatives for personalized dental treatments.

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Effect of strontium ions on the growth of ROS17/2.8 cells on porous calcium polyphosphate scaffolds

Cited by 193 publications

References 29 publications

Ion release from SrO-CaO-TiO2-P2O5 glasses in Tris buffer solution

Ion release from SrO-CaO-TiO2-P2O5 glasses in Tris buffer solution

Effect of strontium ions on calcification of preosteoblasts cultured on porous calcium- and phosphate-containing titanium oxide layers formed by micro-arc oxidation

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

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