Effect of Stress-free Therapy on Cerebral Blood Flow: Comparisons among patients with metabolic cardiovascular disease, healthy subjects and placebo-treated subjects

Abstract

We have developed a novel Stress-free Therapy ® wherein Pinpoint Plantar Long-wavelength Infrared Light Irradiation (PP-LILI) increases peripheral-deep body temperature and blood flow volume and stabilizes blood pressure as well as significantly reduces stress hormones such as adrenocorticotropic hormone (ACTH) and cortisol without using drugs. Furthermore, we demonstrated that this therapeutic method significantly improves blood glucose and insulin resistance in patients with type 2 diabetes. 1, 2) Based on these initial results, we determined the presence or absence and the degree of the preventive effect of Stress-free Therapy ® on diabetes, which is considered to be present in at least 10% of the Japanese population. As there are no subjective symptoms in the early stage of diabetes, which is detected based on high blood glucose levels, patients do not generally visit a hospital to receive proper treatments. When diabetes is left untreated, it results in decreased cerebral blood flow, inducing Alzheimer's disease, and moreover, serious complications such as stroke, myocardial infarction, retinopathy, nephropathy, and neuropathy. 3-6) Herein, we comparatively examined the effect of Stress-free Therapy ® on cerebral blood flow volume in patients with metabolic cardiovascular disease such as diabetes, healthy volunteers, and placebo-treated patients.

Influences of Pinpoint Plantar Long-Wavelength Infrared Light Irradiation (Stress-Free Therapy) on Chorioretinal Hemodynamics, Atherosclerosis Factors, and Vascular Endothelial Growth Factor

“…We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) suppresses the stress reaction mediated by cortisol and contributes to alleviation of insulin resistance and elevation of intracranial blood flow in patients with type 2 DM. 5 , 6 , 7 , 8 We have additionally demonstrated that SFT activates the immunoresponsive CD19 + CD24hi and CD38hi B-reg cell groups and induces the expression of IL-10 on lymphocytes. 9 …”

“…3 , 11 SFT has already demonstrated efficacy in alleviating DM and dementia and is expected to be useful for preventing Sdiabetes-related dementia by alleviating insulin resistance and increasing intracranial blood flow. 7 , 8 …”

Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells

“…Our previous study showed that pinpoint plantar longwavelength infrared light irradiation (PP-LILI) stimuli normalizes blood flow and pressure, suppresses ACTH and cortisol levels and improves type II diabetes [1][2][3] . All these evidences suggested that PP-LILI stimuli affect systemic homeostasis and thus it was thought that the stimuli also affect immune system.…”

Effect of hangekobokuto for amelioration of aggressiveness and social behavior in socially isolated mice

“…For example, the developmental environment in the juvenile stage is considered one of the pathogenetic factors of mental disease, and rodents reared in isolation for a long time in the juvenile stage serve as important model animals . Rearing small laboratory animals such as mice and rats individually for a long time leads to behavioral changes not seen in group‐reared normal animals, called “isolation syndrome” , which includes anxiety, depression, increased aggression, and memory disorder . Isolation syndrome is used as a model for human mental diseases such as schizophrenia, anxiety disorder, mood disorder, and drug dependence .…”