Effect of Streptozotocin-Induced Hyperglycaemia on Intravenous Pharmacokinetics and Acute Cardiotoxicity of Doxorubicin in Rats

Al‐Shabanah, Othman A.; El‐Kashef, Hassan A.; Badary, Osama A.; Al‐Bekairi, Abdullah M.; Elmazar, Mohamed M.

doi:10.1006/phrs.1999.0568

Cited by 36 publications

(33 citation statements)

References 17 publications

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“…Contradictory reports can be found in the literature on the relationship between diabetes and serum creatine kinase activity, which has been variously described as increasing or decreasing in diabetes [22-25]. We have previously shown [19] that under the same conditions as those employed here the muscle changes resulting from induced diabetes are not reflected in altered serum creatine kinase activity and on this basis it appears that administration of B. forficata decoction does not enhance muscle cytotoxicity.…”

Section: Discussionsupporting

confidence: 54%

Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats

Pepato

Baviera

Vendramini

et al. 2004

BMC Complement Altern Med

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BackgroundPrevious experiments have shown that a decoction of Bauhinia forficata leaves reduces the changes in carbohydrate and protein metabolism that occur in rats with streptozotocin-induced diabetes. In the present investigation, the serum activities of enzymes known to be reliable toxicity markers were monitored in normal and streptozotocin-diabetic rats to discover whether the use of B. forficata decoction has toxic effects on liver, muscle or pancreas tissue or on renal microcirculation.MethodsAn experimental group of normal and streptozotocin-diabetic rats received an aqueous decoction of fresh B. forficata leaves (150 g/L) by mouth for 33 days while a control group of normal and diabetic rats received water for the same length of time. The serum activity of the toxicity markers lactate dehydrogenase, creatine kinase, amylase, angiotensin-converting enzyme and bilirubin were assayed before receiving B. forficata decoction and on day 19 and 33 of treatment.ResultsThe toxicity markers in normal and diabetic rats were not altered by the diabetes itself nor by treatment with decoction. Whether or not they received B. forficata decoction the normal rats showed a significant increase in serum amylase activity during the experimental period while there was a tendency for the diabetic rats, both treated and untreated with decoction, to have lower serum amylase activities than the normal rats.ConclusionsAdministration of an aqueous decoction of B. forficata is a potential treatment for diabetes and does not produce toxic effects measurable with the enzyme markers used in our study.

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Section: Discussionsupporting

confidence: 54%

Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats

Pepato

Baviera

Vendramini

et al. 2004

BMC Complement Altern Med

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“…The cardiotoxicity of xenobiotics can be evaluated using the serum activity of marker enzymes especially LDH and creatine kinase (CK), which are distributed throughout the body and have isoenzymes that are recognized as markers for liver muscle and heart lesion 33 . Contradictory reports are available in the literature on the relationship between diabetes and CK activity 34,35 . However, Hayden and Tyagi 28 linked the observed increase in the serum CK and LDH levels of diabetic rats to cardiac muscular damage caused by the disease.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats

Adaramoye¹

2013

Af Hlth Sci

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“…Doxorubicin (DOX), an anthracyclinic antibiotic, is a DNAinteracting drug for treatment of various cancers especially breast, ovarian, prostate, brain, cervix and lung cancers [26]. Clinical application of doxorubicin, however, is limited because of its short half-life [27] and severe toxicity to normal tissues, especially gastrointestinal toxicity and heart failure [26]. The cardiotoxicity confines the cumulative dose of DOX to 500-600 mg/m 2 , which still can be increased for tumor but not for heart disease [28].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS): Conjugation chemistry, characterization, in vitro and in vivo evaluation

2008

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Effect of Streptozotocin-Induced Hyperglycaemia on Intravenous Pharmacokinetics and Acute Cardiotoxicity of Doxorubicin in Rats

Cited by 36 publications

References 17 publications

Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats

Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats

Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats

Doxorubicin conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS): Conjugation chemistry, characterization, in vitro and in vivo evaluation

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