Effect of streptozotocin-induced diabetes on myocardial blood flow reserve assessed by myocardial contrast echocardiography in rats.

Cosyns, Bernard; Droogmans, Steven; Hernot, Sophie; Degaillier, Céline; Garbar, Christian; Weytjens, Caroline; Roosens, Bram; Schoors, Danny; Lahoutte, Tony; Franken, Philippe; Camp, Guy Van

doi:10.1186/1475-2840-7-26

Cited by 25 publications

(28 citation statements)

References 44 publications

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“…Using this technique it has been shown that myocardial blood flow reserve, as a measure for vascular function, is reduced in type 1 diabetic rats [8] and type 1 diabetic patients [9] when compared to normoglycaemic controls. There are currently limited data available on myocardial perfusion in glucose intolerance.…”

Section: Introductionmentioning

confidence: 99%

High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study

Brom

Bulte

Kloeze

et al. 2012

Cardiovasc Diabetol

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BackgroundGlucose intolerance is a major health problem and is associated with increased risk of progression to type 2 diabetes mellitus and cardiovascular disease. However, whether glucose intolerance is related to impaired myocardial perfusion is not known. The purpose of the present study was to study the effect of diet-induced glucose intolerance on myocardial function and perfusion during baseline and pharmacological induced hyperaemia.MethodsMale Wistar rats were randomly exposed to a high fat diet (HFD) or control diet (CD) (n = 8 per group). After 4 weeks, rats underwent an oral glucose tolerance test. Subsequently, rats underwent (contrast) echocardiography to determine myocardial function and perfusion during baseline and dipyridamole-induced hyperaemia (20 mg/kg for 10 min).ResultsFour weeks of HFD feeding resulted in glucose intolerance compared to CD-feeding. Contractile function as represented by fractional shortening was not altered in HFD-fed rats compared to CD-fed rats under baseline conditions. However, dipyridamole increased fractional shortening in CD-fed rats, but not in HFD-fed rats. Basal myocardial perfusion, as measured by estimate of perfusion, was similar in CD- and HFD-fed rats, whereas dipyridamole increased estimate of perfusion in CD-fed rats, but not in HFD-fed rats. However, flow reserve was not different between CD- and HFD-fed rats.ConclusionsDiet-induced glucose intolerance is associated with impaired myocardial function during conditions of hyperaemia, but myocardial perfusion is maintained. These findings may result in new insights into the effect of glucose intolerance on myocardial function and perfusion during hyperaemia.

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Section: Introductionmentioning

confidence: 99%

High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study

Brom

Bulte

Kloeze

et al. 2012

Cardiovasc Diabetol

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show abstract

“…68 Finally, myocardial blood flow reserve is abnormal in individuals with diabetes without epicardial coronary disease, 69 and there is reduced myocardial capillary density. 70 Hypertension and renal dysfunction in type 2 diabetes mellitus Diabetic nephropathy, a common consequence of T2DM, leads to accelerated cardiovascular disease and hypertension. Patients with diabetes, hypertension and LV hypertrophy have a high incident rate of heart failure (1.9%).…”

mentioning

confidence: 99%

Review article: Left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease — do we need to screen our patients?

Roberts

Clark

Witte

2009

Diabetes and Vascular Disease Research

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The metabolic syndrome and its components, glucose intolerance, T2DM, hypertension, dyslipidaemia and obesity are increasingly common. Patients with the metabolic syndrome have a higher prevalence of chronic heart failure (CHF) and, once diagnosed, CHF in such subjects is associated with a higher mortality than in those without this co-morbidity. However, early diagnosis of LV systolic dysfunction and symptomatic heart failure may prevent deterioration of heart failure and improve prognosis. The aim of this article is to summarise the prevalence of CHF in people with obesity, hypertension and T2DM, and to review how each co-morbid condition might predispose to and complicate the clinical diagnosis of CHF.

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“…It affirms the concept that asymptomatic vasculopathy is present in individuals with prediabetes who are thus at high risk of developing cardiovascular complications. 16 This suggests that determination of blood viscosity in clinical practice may be a useful supplementary tool in the assessment of vasculopathy and SCVD in prediabetes and undiagnosed diabetes. The absence of difference between the DM and DM+CVD groups in the present study shows that oxidative stress risk in DM is as high as that in DM+CVD individuals, which has significant prognostic implications.…”

Section: Discussionmentioning

confidence: 98%

Blood viscosity at different stages of diabetes pathogenesis

Richards

Nwose

2010

British Journal of Biomedical Science

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Hyperglycaemia-induced oxidative stress is implicated as a cause of increased whole blood viscosity (WBV), which is a clinically modifiable risk factor for cardiovascular disease (CVD). However, whether or not there is variation in WBV at different stages of diabetes mellitus (DM) has yet to be confirmed. The sensitivity of underlying oxidative stress has also yet to be investigated. A total of 154 participants representing different stages of DM pathogenesis were selected for the study. Healthy control, prediabetes, DM and DM+CVD groups were compared for variation in WBV levels. The prevalence of oxidative stress, indicated by abnormal levels of erythrocyte glutathione, malondialdehyde and methaemoglobin, associated with high WBV was evaluated. The results showed a statistically significant difference in WBV between groups (P < 0.03). The level of viscosity was significantly lower in the control group relative to the prediabetes group (P < 0.01) and DM+CVD group (P < 0.04). There was no statistically significant difference between the DM+CVD and prediabetes groups. Greater than 76% prevalence of oxidative stress was shown to be associated with high WBV, reaching 95% prevalence in prediabetes. The study showed that WBV varies between individuals with different stages of diabetic macrovascular pathogenesis, including prediabetes. Redefining the criteria for use of WBV on the basis of sensitivity to underlying oxidative stress, rather than specificity to a disease condition, means that this easily performed test is an option to consider in an all-inclusive laboratory approach to early intervention against future diabetic macrovascular complications. This is particularly important for individuals with subclinical hyperglycaemia.

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Effect of streptozotocin-induced diabetes on myocardial blood flow reserve assessed by myocardial contrast echocardiography in rats.

Cited by 25 publications

References 44 publications

High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study

High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study

Review article: Left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease — do we need to screen our patients?

Blood viscosity at different stages of diabetes pathogenesis

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