Effect of streptococcal hæmolysins on Ehrlich ascites tumour cells

Ginsburg, Isaac; Grossowicz, N.

doi:10.1002/path.1700800114

Cited by 36 publications

(38 citation statements)

References 7 publications

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“…The destructive action of live hemolytic streptococci on cancer cells was demonstrated by several workers [21,23,25,32,39,58]. Particularly noteworthy are the observations made by Shimizu et al of our laboratories [58].…”

Section: Destruction Of Tumor Cells By S-streptococcimentioning

confidence: 71%

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Studies on the Anticancer and Streptolysin S‐Forming Abilities of Hemolytic Streptococci

Okamoto

Shoin

Koshimura

et al. 1967

Japanese Journal of Microbiology

219

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Section: Destruction Of Tumor Cells By S-streptococcimentioning

confidence: 71%

“…Meanwhile, studies on the anticancer ability of hemolytic streptococci using experimental animal have also been reported by several investigators in other countries [6-13, 17, 18,21,23,25]. By surveying the principal data so far presented, we may proceed as follows.…”

mentioning

confidence: 89%

Studies on the Anticancer and Streptolysin S‐Forming Abilities of Hemolytic Streptococci

Okamoto

Shoin

Koshimura

et al. 1967

Japanese Journal of Microbiology

219

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“…CBH.--As shown previously, streptococci possessing CBH activity are capable of injuring a variety of mammalian cells in vitro (7,8). Since the lysis of red blood cells by washed streptococci was induced in the apparent absence of extracellular hemolysin, experiments were designed in an attempt to determine whether microscopic evidence would be obtained of physical contact between the streptococci and RBC or ascites tumor cells prior to the lysis, and to make microscopic observations of the changes in the cells in the course of such lysis.…”

Section: Cytologic Changes Induced In Rbc and Ehrlich Ascites Tumomentioning

confidence: 76%

Oxygen-Stable Hemolysins of Group a Streptococci

Ginsburg

Harris

1965

The Journal of Experimental Medicine

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In the previous paper (1) data were presented on the relationship of the cellbound hemolysin (CBtI) of a Group A streptococci to the oxygen-stable hemolysin produced by these organisms in the presence of RNA. It was shown that a number of agents and conditions affected similarly the formation and activity of the cell-bound and RNA-induced hemolysins. The fact that (in the absence of an effective inducer of the oxygen-stable hemolysins, such as RNA) no traces of soluble hemolysin can be detected in the suspending medium of washed streptococci even with high CBH activity suggested that in the absence of such an inducer a hemolytic moiety can be transferred directly from the streptococci to the red cells, as has, in fact, been indicated in a preliminary report (1). The hemolysin thus transferred would act on some cell membrane component to cause the permeability changes which result in the lysis of the cells. However, the actual mechanism of lysis of red blood cells (RBC) and other mammalian cells by CBH (2) and the oxygen-stable streptococcal hemolysins is not understood.In the present paper experiments on the mechanism of lysis of red blood cells by washed streptococci possessing CBH activity are reported, and a proposed relationship between the CBH and the group of streptococcal oxygen-stable hemolysins is presented. Materials and MethodsThe streptococcal strain, culture media, and the preparation and titration of RNA and the cell-bound hemolysin were described in a preceding paper (1). Group O human red blood cells were used throughout.

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“…Since SLS is known to have haemolytic and cytopathic properties [2] the effects of saponin, a well known haemolytic agent, on mouse muscle was tested. It was found that 1000 haemolytic units of saponin induced alterations of the muscle which were essentially indistinguishable from those occurring after administration of 1000 Hemolytic Units of SLS.…”

Section: Effect Of Streptolysin S In Micementioning

confidence: 99%