Effect of storage time and donor sex of transfused red blood cells on 1‐year survival in patients undergoing cardiac surgery: an observational study

Desmarets, Maxime; Bardiaux, L.; Benzenine, Éric; Dussaucy, Alain; Binda, Delphine; Tiberghien, Pierre; Quantin, Catherine; Monnet, Élisabeth

doi:10.1111/trf.13537

Cited by 32 publications

(51 citation statements)

References 29 publications

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“…25 A few observational studies that examined the association between donor characteristics and patient outcomes suggested that female RBCs may increase the risk of posttransfusion mortality, 5,26 whereas comparable studies found no associations between donor sex or age and posttransfusion mortality. 27,28 Because packed RBC units contain plasma, these studies could evaluate only the clinical effects of total blood component transfusions; hence, donor plasma and/or RBCs may have been responsible for transfusion-related adverse outcomes.…”

Section: Discussionmentioning

confidence: 99%

Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study

et al. 2017

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Genetic polymorphisms in blood donors may contribute to donor-specific differences in the survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic variability is anticipated to be high in donors with racial admixture from malaria endemic regions such as Africa and Asia. The purpose of this study was to test the hypothesis that donor genetic background, reflected by sex and self-reported ethnicity, significantly modulates RBC phenotypes in storage. High throughput hemolysis assays were developed and used to evaluate stored RBC samples from 11 115 African American, Asian, white, and Hispanic blood donors from 4 geographically diverse regions in the United States. Leukocyte-reduced RBC concentrate-derived samples were stored for 39 to 42 days (1–6°C) and then evaluated for storage, osmotic, and oxidative hemolysis. Male sex was strongly associated with increased susceptibility to all 3 hemolysis measures (P < .0001). African American background was associated with resistance to osmotic hemolysis compared with other racial groups (adjusted P < .0001). Donor race/ethnicity was also associated with extreme (>1%) levels of storage hemolysis exceeding US Food and Drug Administration regulations for transfusion (hemolysis >1% was observed in 3.51% of Asian and 2.47% of African American donors vs 1.67% of white donors). These findings highlight the impact of donor genetic traits on measures of RBC hemolysis during routine cold storage, and they support current plans for genome-wide association studies, which may help identify hereditable variants with substantive effects on RBC storage stability and possibly posttransfusion outcomes.

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Section: Discussionmentioning

confidence: 99%

Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study

et al. 2017

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“…For example, receiving a red cell product from young (<45 years) female blood donor has been associated with up to an 8% increase in the risk of death for each unit transfused compared to receiving an RCC transfusion from a male door [271]. As this observation has not been seen in retrospective analysis of French or Scandinavian patient cohorts [274, 275], more detailed retrospective data linkage studies and prospective clinical studies are needed to help further understanding the role that donor factors have on patient outcomes.…”

Section: Overview: Quality Assessment Of Stored Red Cell Concentratesmentioning

confidence: 99%

Quality Assessment of Established and Emerging Blood Components for Transfusion

Acker

Marks

Sheffield

2016

Journal of Blood Transfusion

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Blood is donated either as whole blood, with subsequent component processing, or through the use of apheresis devices that extract one or more components and return the rest of the donation to the donor. Blood component therapy supplanted whole blood transfusion in industrialized countries in the middle of the twentieth century and remains the standard of care for the majority of patients receiving a transfusion. Traditionally, blood has been processed into three main blood products: red blood cell concentrates; platelet concentrates; and transfusable plasma. Ensuring that these products are of high quality and that they deliver their intended benefits to patients throughout their shelf-life is a complex task. Further complexity has been added with the development of products stored under nonstandard conditions or subjected to additional manufacturing steps (e.g., cryopreserved platelets, irradiated red cells, and lyophilized plasma). Here we review established and emerging methodologies for assessing blood product quality and address controversies and uncertainties in this thriving and active field of investigation.

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“…Monthly collected data included the number of RBC units transfused, the ABO/D blood group, and the departments of the patients who received the RBC units. According to storage age (SA) on the day of transfusion the RBC units were sorted into groups as SA1: 0-15 days (SA on the day of transfusion), SA2: 16-28 days, and SA3: 29-42 days [5,6]. Data regarding national RBC transfusion supplies were provided by the Hellenic National Blood Transfusion Center.…”

Section: Methodsmentioning

confidence: 99%

Red Blood Cell Transfusions in Greece: Results of a Survey of Red Blood Cell Use in 2013

Valsami

Grouzi²,

Pouliakis³

et al. 2017

Tjh

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Objective:Greece is ranked as the second highest consumer of blood components in Europe. For an effective transfusion system and in order to reduce variability of transfusion practice by implementing evidence-based transfusion guidelines it is necessary to study and monitor blood management strategies. Our study was conducted in order to evaluate the use of red blood cell units (RBC-U) in nationwide scale mapping parameters that contribute to their proper management in Greece.Materials and Methods:The survey was conducted by the Working Committee of Transfusion Medicine&Apheresis of the Hellenic Society of Hematology from January to December 2013. The collected data included the number, ABO/D blood group, patients’ department, and storage age of RBC-U transfused.Results:The number of RBC-U evaluated was 103,702 (17.77%) out of 583,457 RBC-U transfused in Greece in 2013. RBC-U transfused by hospital department (mean percentage) was as follows: Surgery 29.34%, Internal Medicine 29.48%, Oncology/Hematology 14.65%, Thalassemia 8.87%, Intensive Care Unit 6.55%, Nephrology 1.78%, Obstetrics/Gynecology 1.46%, Neonatal&Pediatric 0.31%, Private Hospitals 8.57%. RBC-U distribution according to ABO/D blood group was: A: 39.02%, B: 12.41%, AB: 5.16%, O: 43.41%, D+: 87.99%, D-: 12.01%. The majority of RBC-U (62.46%) was transfused in the first 15 days of storage, 25.24% at 16 to 28 days, and 12.28% at 29-42 days.Conclusion:Despite a high intercenter variability in RBC transfusions, surgical and internal medicine patients were the most common groups of patients transfused with an increasing rate for internal medicine patients. The majority of RBC-U were transfused within the first 15 days of storage, which is possibly the consequence of blood supply insufficiency leading to the direct use of fresh blood. Benchmarking transfusion activity may help to decrease the inappropriate use of blood products, reduce the cost of care, and optimize the use of the voluntary donor’s gift.

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Effect of storage time and donor sex of transfused red blood cells on 1‐year survival in patients undergoing cardiac surgery: an observational study

Abstract: In this first study of survival after transfusion in France, there was no significant effect for age of blood or donor sex. Contrary to previously reported data, female RBCs appear to be safe for male recipients.

Cited by 32 publications

References 29 publications

Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study

Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study

Quality Assessment of Established and Emerging Blood Components for Transfusion

Red Blood Cell Transfusions in Greece: Results of a Survey of Red Blood Cell Use in 2013

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