Effect of stimulation of beta-adrenergic receptors on neuronal activity in primary motor cortex of the rat

Lukhanina, E. P.; Kolomiets, B. P.; Pil’kevich, N. A.

doi:10.1016/s0304-3940(03)00065-x

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…It seems probable that changes in the activity of β1 and β2 adrenoreceptors influence spiking of neurons of the sensorimotor cortex in a dissimilar manner. It is supposed that noradrenergic suppression of impulse activity is realized mostly via β1 adrenoreceptors [8,9]. In our experiments, intensification of the activity of cortical neurons after the action of the conditioning stimulus was more clearly manifested upon application of the β2 adrenoreceptor agonist metaproterenol than upon the action of propranolol.…”

Section: Resultssupporting

confidence: 45%

Effect of stimulation of β adrenoreceptors on conditioned reflex-related spike activity of neurons of the cat somatosensory cortex

Man’kovskaya

2011

Neurophysiology

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Using extracellular recording of impulse activity of pyramidal neurons of the cat somatosensory cortex generated in the course of realization of an operant conditioned reflex, we examined effects of microiontophoretic applications of an agonist of β2 adrenoreceptors, metaproterenol, and of an antagonist of β adrenoreceptors, propranolol, on the frequency of this impulsation. Applications of propranolol induced intensification of both background and reflex-related spiking. The effect of metaproterenol was manifested as moderate intensification of background discharges, a noticeable increase in the frequency of evoked impulsation, and an increase in the latency of impulse reactions. It is supposed that noradrenergic projections to the neocortex intensify neuronal activity via activation of β2 adrenoreceptors and suppress this activity via influencing mostly β1 adrenoreceptors. Such effects of synaptically active agents should probably be taken into account in the treatment of neurological diseases, namely epilepsy, neurodegenerative disorders, psychoemotional shifts, etc., which are accompanied by emotional and cognitive disorders.

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Section: Resultssupporting

confidence: 45%

Effect of stimulation of β adrenoreceptors on conditioned reflex-related spike activity of neurons of the cat somatosensory cortex

Man’kovskaya

2011

Neurophysiology

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“…Extracellular recordings performed in M1 layers III to V of anesthetized rats showed that iontophoretic application of β2-ARs agonists either decreased or increased putative pyramidal firing rate whereas β1-ARs agonists decreased pyramidal firing rate (Lukhanina et al, 2003 ). These cellular effects of NE in M1 suggest a bimodal modulation of firing activity in M1 by NE (Figure 3 ).…”

Section: Norepinephrine Modulation Of Motor Cortex Functionmentioning

confidence: 99%

Monoaminergic Modulation of Motor Cortex Function

Vitrac

Benoît-Marand

2017

Front. Neural Circuits

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Elaboration of appropriate responses to behavioral situations rests on the ability of selecting appropriate motor outcomes in accordance to specific environmental inputs. To this end, the primary motor cortex (M1) is a key structure for the control of voluntary movements and motor skills learning. Subcortical loops regulate the activity of the motor cortex and thus contribute to the selection of appropriate motor plans. Monoamines are key mediators of arousal, attention and motivation. Their firing pattern enables a direct encoding of different states thus promoting or repressing the selection of actions adapted to the behavioral context. Monoaminergic modulation of motor systems has been extensively studied in subcortical circuits. Despite evidence of converging projections of multiple neurotransmitters systems in the motor cortex pointing to a direct modulation of local circuits, their contribution to the execution and learning of motor skills is still poorly understood. Monoaminergic dysregulation leads to impaired plasticity and motor function in several neurological and psychiatric conditions, thus it is critical to better understand how monoamines modulate neural activity in the motor cortex. This review aims to provide an update of our current understanding on the monoaminergic modulation of the motor cortex with an emphasis on motor skill learning and execution under physiological conditions.

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“…Psychological stress provokes the release of neuroendocrine hormones, such as catecholamines activating adrenergic pathways, a process that is fundamental for the initiation of the “fight-or-flight” response. This adrenergic activation is not only the main mechanism in the initiation and execution of the flight-or-fight response but it also plays an important role in immune regulation [ 93 , 94 , 95 ], bone homeostasis [ 96 , 97 , 98 ], muscle hypertrophy and atrophy [ 99 , 100 ], the cardiovascular system [ 101 ], neuronal activity in primary motor cortex [ 102 ], and neuronal plasticity and memory [ 103 , 104 , 105 ] among others. Here we report the synergistic effects of radiation, microgravity and adrenergic receptor stimulation on DNA damage response in quiescent human primary lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells

Moreno‐Villanueva

Feiveson

Krieger

et al. 2018

IJMS

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The implementation of rotating-wall vessels (RWVs) for studying the effect of lack of gravity has attracted attention, especially in the fields of stem cells, tissue regeneration, and cancer research. Immune cells incubated in RWVs exhibit several features of immunosuppression including impaired leukocyte proliferation, cytokine responses, and antibody production. Interestingly, stress hormones influence cellular immune pathways affected by microgravity, such as cell proliferation, apoptosis, DNA repair, and T cell activation. These pathways are crucial defense mechanisms that protect the cell from toxins, pathogens, and radiation. Despite the importance of the adrenergic receptor in regulating the immune system, the effect of microgravity on the adrenergic system has been poorly studied. Thus, we elected to investigate the synergistic effects of isoproterenol (a sympathomimetic drug), radiation, and microgravity in nonstimulated immune cells. Peripheral blood mononuclear cells were treated with the sympathomimetic drug isoproterenol, exposed to 0.8 or 2 Gy γ-radiation, and incubated in RWVs. Mixed model regression analyses showed significant synergistic effects on the expression of the β2-adrenergic receptor gene (ADRB2). Radiation alone increased ADRB2 expression, and cells incubated in microgravity had more DNA strand breaks than cells incubated in normal gravity. We observed radiation-induced cytokine production only in microgravity. Prior treatment with isoproterenol clearly prevents most of the microgravity-mediated effects. RWVs may be a useful tool to provide insight into novel regulatory pathways, providing benefit not only to astronauts but also to patients suffering from immune disorders or undergoing radiotherapy.

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Effect of stimulation of beta-adrenergic receptors on neuronal activity in primary motor cortex of the rat

Cited by 4 publications

References 15 publications

Effect of stimulation of β adrenoreceptors on conditioned reflex-related spike activity of neurons of the cat somatosensory cortex

Effect of stimulation of β adrenoreceptors on conditioned reflex-related spike activity of neurons of the cat somatosensory cortex

Monoaminergic Modulation of Motor Cortex Function

Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells

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