Effect of stevia leaves (Stevia rebaudiana Bertoni) on diabetes: A systematic review and meta‐analysis of preclinical studies

Abstract

Diabetes is a common metabolic disease resulting from insulin deficiency or insulin resistance at the cellular level. It is associated with several noncommunicable diseases (NCDs), such as dysfunction or failure of organs, like kidneys, heart, blood vessel, thus predisposed to hypertension, renal disease, ocular diseases, stroke, heart failure, obesity, etc. (Mellitus, 2005). Among other types of diabetes, it is estimated that around 90-95% of patients with diabetes are suffering from Type-2-diabetes (T2D) in the world (Issa & Hussen Bule, 2015).

Effect of steviol glycosides as natural sweeteners on glucose metabolism in adult participants

“…There have been three meta-analyses summarizing the evidence for the effects of SGs on glucose metabolism. 21,42,58 Chowdhury et al 58 performed a pooled analysis of animal studies, showing a significant benefit to blood glucose control. Another meta-analysis based on six RCTs reported a mild and significant reduction in FBG (MD = −0.63 mg dl −1 , CI −0.90 to −0.36) in SGs.…”

Herb Stevia rebaudiana’s functionalities, safety and applications: a review

“…were significantly lowered in the group treated with stevia. Based on those clinical data, Chowdhury et al (2022) took the lead in carrying out a meta-analysis via random-effect model to investigate the dose impact of stevia on blood glucose, and their analytical results verified that stevia leaf had an antihyperglycemic effect and could reduce the blood glucose level at doses of 200, 300 and 400 mg/kg. However, strictly compared with actual medical treatment, stevia extracts exhibit less effective antidiabetic activities.…”