Effect of steroids on β‐adrenoceptor‐mediated relaxation of pig bronchus

Foster, Paul S.; Goldie, Roy G.; Paterson, J. W.

doi:10.1111/j.1476-5381.1983.tb09409.x

Cited by 111 publications

(57 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data are similar to those reported in a survey on airway smooth muscle tone and bronchial responsiveness, as well as to differences in the deposition of tussigenic agents in the airways due to the smaller airway size in females. (18)(19)(20) Our study also revealed that the frequency of the three types of cough decreases with age. Age was negatively associated with all types of cough, which is in agreement with the findings of other investigators.…”

Section: Discussionsupporting

confidence: 48%

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

et al. 2010

View full text Add to dashboard Cite

Objective: The aim of this study was to determine the factors associated with nocturnal, productive and dry cough among young adults in Nigeria. Methods: We evaluated 498 subjects, 20-44 years of age, in Ilorin, Nigeria, using the European Community Respiratory Health Survey (ECRHS) questionnaire, administered by trained interviewers. Results: Nocturnal cough was associated with asthma (OR = 10.87; p < 0.01), nasal allergy (OR = 6.33; p < 0.01), smoking (OR = 3.10; p < 0.01), skilled manual and non-manual work (OR = 2.86 and 2.10, respectively; p < 0.01 for both) and female gender (OR = 1.33; p = 0.17). Productive cough was associated with skilled manual and non-manual work (OR = 3.82 and 3.03, respectively; p < 0.01 for both), smoking (OR = 3.10; p < 0.01), asthma (OR = 3.27; p < 0.01) and nasal allergy (OR = 5.81; p < 0.01). Dry cough was associated with asthma (OR =5.18; p < 0.01) obesity (OR =1.88; p = 0.19), smoking (OR = 1.77; p = 1.44), nasal allergy (OR = 1.45; p = 0.26) and female gender (OR =1.36; p = 0.33). Age, gender, type of residence and obesity were not significantly associated with any type of cough (p > 0.05). Conclusions: Early prevention and treatment of conditions associated with cough, as well as the modification of social factors commonly associated with cough, are needed in order to reduce respiratory morbidity. Resultados: A tosse noturna apresentou associações com asma (OR = 10,87; p < 0,01), alergia nasal (OR = 6,33; p < 0,01), tabagismo (OR = 3,10; p < 0,01), trabalho manual e trabalho não manual especializados (OR = 2,86 e 2,10, respectivamente; p < 0,01 para ambos) e gênero feminino (OR = 1,33; p = 0,17). A tosse produtiva apresentou associações com trabalho manual e trabalho não manual especializados (OR = 3,82 e 3,03, respectivamente; p < 0,01 para ambos), tabagismo (OR = 3,10; p < 0,01), asma (OR = 3,27; p < 0,01) e alergia nasal (OR = 5,81; p < 0,01). A tosse seca apresentou associações com asma (OR =5,18; p < 0,01) obesidade (OR =1,88; p = 0,19), tabagismo (OR = 1,77; p = 1,44), alergia nasal (OR = 1,45; p = 0,26) e gênero feminino (OR =1,36; p = 0,33). A idade, o gênero, o tipo de residência e a obesidade não se associaram significativamente a nenhum tipo de tosse (p > 0,05). Conclusões: A prevenção precoce e o tratamento de condições associadas à tosse, assim como a modificação de fatores sociais comumente associados à tosse, são necessários a fim de reduzir a morbidade respiratória.Descritores: Tosse; Tabagismo; Asma; Rinite; Nigéria. longitude. The minimum sample size was arrived at through the use of a Cochran formula (14) :where N is the sample size, p is the prevalence of cough in Nigeria (taken to be 50%, since the prevalence was unknown), q = (1 − p), Z is the standard normal deviation (usually set at 1.96, which corresponds to the 95% confidence interval), and d is the desired degree of accuracy (set at 0.05 to tolerate a 5% error, N = 384). The minimum sample size was determined to be 368. The study area consists of twelve electoral wards, as defined by the s...

show abstract

Section: Discussionsupporting

confidence: 48%

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

et al. 2010

View full text Add to dashboard Cite

show abstract

“…We have previously shown that the COMT inhibitor U-0521 (30 gM) increased the potency of isoprenaline by about 6 fold but failed to alter the potencies of fenoterol or NA (Foster et al, 1983). It was also shown that cortisol (80 pM) caused a 7 fold increase in isoprenaline potency in pig bronchus and that this was best explained in terms of inhibition of COMT and/or of extraneuronal uptake.…”

Section: Resultsmentioning

confidence: 87%

Effect of hypothermia on β₁‐adrenoceptor‐mediated relaxation of pig bronchus

Foster

Goldie

Paterson

et al. 1983

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

1 The relaxant potencies of (±)-isoprenaline and of (-)-noradrenaline (NA) in the pig isolated bronchus were increased 5.4 and 3.1 fold respectively by lowering the organ bath temperature from 37°C to 27°C, whereas the potencies of the non-catecholamine P-adrenoceptor agonists fenoterol and orciprenaline were not significantly changed. 2 At 37C, the catechol-O-methyl transferase (COMT) inhibitor U-0521 (30 LM), caused a 7.2 fold increase in the potency of isoprenaline but had no effect on the potency of fenoterol. At 27°C the potency of isoprenaline was similar in the absence or presence of U-0521 (30 pM). Furthermore, in bronchi where extraneuronal uptake was inhibited by phenoxybenzamine, the potency of NA was not significantly altered by reducing bathing temperature from 37°C to 27°C. 3 These results suggest that the hypothermic potentiation of isoprenaline in pig bronchus resulted from inhibition of COMT or of access to COMT, rather than from sensitization of Pi-adrenoceptors.

show abstract

“…Estrogen relaxes pre-contracted ASM preparations (Pang et al 2002) and potentiates the relaxation induced by catecholamines and b 2 -agonists (Foster et al 1983, Townsend et al 2012b. Estrogens also reduce the increased contraction observed in ASM passively sensitized with serum of atopic asthmatics (Dimitropoulou et al 2005), as well as the in vivo responsiveness to an aerosolized mixture of spasmogens (Pang et al 2002).…”

Section: Gonadsmentioning

confidence: 99%

“…Progesterone and one of its derivatives, 5b-pregnenolone, attenuate the contraction of isolated ASM (Perusquia et al 1997). Progesterone also increases the relaxation induced by b 2 -agonists (Foster et al 1983). In vivo, progesterone does not affect the level of airway responsiveness in healthy mice (Hellings et al 2003) but amplifies the development of AHR in a murine model of asthma (Hellings et al 2003).…”

Section: Gonadsmentioning

confidence: 99%

“…The direction of the effect depends on the state of ASM activation. On one hand, androgens relax pre-contracted ASM (Kouloumenta et al 2006, Bordallo et al 2008, Montano et al 2014 and potentiate the relaxing effect of b 2 -agonists (Foster et al 1983, Bordallo et al 2008, which suggest an overall bronchodilator effect. On the other hand, in the same ASM preparations and at the same concentrations, androgens potentiate the contractile response to a spasmogen, which suggest a constrictor effect (Bordallo et al 2008).…”

Section: Gonadsmentioning

confidence: 99%

See 1 more Smart Citation

Endocrine regulation of airway contractility is overlooked

Bossé

2014

Journal of Endocrinology

View full text Add to dashboard Cite

Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated activation of the smooth muscle surrounding the airways, as well as a propensity of the airways to narrow excessively in response to a spasmogen (i.e. contractile agonist), a feature called airway hyperresponsiveness. The level of airway smooth muscle (ASM) activation is putatively controlled by mediators released in its vicinity. In asthma, many mediators that affect ASM contractility originate from inflammatory cells that are mobilized into the airways, such as eosinophils. However, mounting evidence indicates that mediators released by remote organs can also influence the level of activation of ASM, as well as its level of responsiveness to spasmogens and relaxant agonists. These remote mediators are transported through circulating blood to act either directly on ASM or indirectly via the nervous system by tuning the level of cholinergic activation of ASM. Indeed, mediators generated from diverse organs, including the adrenals, pancreas, adipose tissue, gonads, heart, intestines, and stomach, affect the contractility of ASM. Together, these results suggest that, apart from a paracrine mode of regulation, ASM is subjected to an endocrine mode of regulation. The results also imply that defects in organs other than the lungs can contribute to asthma symptoms and severity. In this review, I suggest that the endocrine mode of regulation of ASM contractility is overlooked.

show abstract

Effect of steroids on β‐adrenoceptor‐mediated relaxation of pig bronchus

Cited by 111 publications

References 27 publications

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

Effect of hypothermia on β₁‐adrenoceptor‐mediated relaxation of pig bronchus

Endocrine regulation of airway contractility is overlooked

Contact Info

Product

Resources

About

Effect of steroids on β‐adrenoceptor‐mediated relaxation of pig bronchus

Cited by 111 publications

References 27 publications

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

Effect of hypothermia on β1‐adrenoceptor‐mediated relaxation of pig bronchus

Endocrine regulation of airway contractility is overlooked

Contact Info

Product

Resources

About

Effect of hypothermia on β₁‐adrenoceptor‐mediated relaxation of pig bronchus