Effect of steroid injections on the rotator cuff: An experimental study in rats

Tillander, Bo; Franzén, Lennart; Karlsson, Maria H; Norlin, Rolf

doi:10.1016/s1058-2746(99)90141-6

Cited by 122 publications

(80 citation statements)

References 27 publications

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“…In this group the bursitis was marked in all cases. Since we have previously shown that the injection itself does not cause any direct damage [43], which was confirmed in this study in the controls and group A, we draw the conclusion that, the subacromial bursitis induce fibrocartilaginous metaplasia and even bony metaplasia. This was found in the supraspinatus tendon but not in the infraspinatus tendon.…”

Section: Discussionsupporting

confidence: 87%

“…Age is an important :ontributing factor [21,22]. But also other external facors such as glucocorticoid injections may damage the :ollagen fibres of the rotator cuff [43].…”

Section: [Ntroductionmentioning

confidence: 99%

“…Chard et al [7] also found fibrocartilaginous metaplasia within the rotator cuff tendons in cadavers. In order to investigate the subacromial space the rat model has been developed [27,36,40,41,43]. Using this model Schneeberger et al [39] showed that experimental extrinsic subacromial impingement caused bursa1 side tears of the infraspinatus tendon.…”

Section: [Ntroductionmentioning

confidence: 99%

“…The injections were performed as previously described [43]: from this previous study we know that the injection is located in the subacromial space above the rotator cuff and that repeated subacromial saline injections do not damage the tendons. All animals were injected under aseptic circumstances in their left shoulder under a short anaesthesia induced by carbon dioxide.…”

Section: The Controls Received Subacromial Injections Ofmentioning

confidence: 99%

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Carrageenan‐induced subacromial bursitis caused changes in the rat's rotator cuff

Tillander

Franzén

Nilsson

et al. 2001

Journal Orthopaedic Research

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ibstractThis study was designed to investigate the histologic expression of the rat's supra-and infraspinatus tendons in carrageenannduced subacromial bursitis. Thirty-two rats received subacromial injections with carrageenan ( n = 28) or saline ( n = 4). The endons were analysed microscopically after staining with hematoxyline eosin, Van Giesons hematoxyline and immunofluorescent itaining of fibronectin and fibrinogen. In the controls (saline x 10) and group A (carrageenan x 5 ) there were no changes in the endons. In group B (carrageenan x 10) 3/8 rats showed macrophages between the collagen fibres and an increased staining of ibronectin. In group C (double dosis carrageenan) all rats had signs of fibrocartilaginous metaplasia in the supraspinatus endon. In eight of these specimens even bony metaplasia was seen. The infraspinatus tendon showed fibrosis but no fibro-:artilaginous metaplasia. The results showed that iatrogenic bursitis after carrageenan subacromial injections was associated with narked changes of the supraspinatus tendon.

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Section: Discussionsupporting

confidence: 87%

“…Age is an important :ontributing factor [21,22]. But also other external facors such as glucocorticoid injections may damage the :ollagen fibres of the rotator cuff [43].…”

Section: [Ntroductionmentioning

confidence: 99%

Section: [Ntroductionmentioning

confidence: 99%

Section: The Controls Received Subacromial Injections Ofmentioning

confidence: 99%

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Carrageenan‐induced subacromial bursitis caused changes in the rat's rotator cuff

Tillander

Franzén

Nilsson

et al. 2001

Journal Orthopaedic Research

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“…An animal study reported that steroid injections for three consecutive weeks did not induce tendon damage, but five or more biweekly steroid injections caused degradation and necrosis of collagen 4) . In essence, steroid injections are safe overall with an effective outcome in the short-term, but frequent use of steroids may interfere with tendon healing and induce tendon necrosis.…”

Section: Discussionmentioning

confidence: 99%

Isolated Infraspinatus Tear and Suprascapular Nerve Neuropathy after Barbotage and Steroid Injection of Calcific Tendinitis

Bang

2016

Korean J Sports Med

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Isolated rupture of infraspinatus after barbotage for calcific tendinitis has not been reported in the literature. We report on a case of isolated infraspinatus rupture and suprascapular nerve neuropathy after steroid injection and barbotage of calcific tendinitis in rotator cuff. At 6-month follow-up after surgery, satisfactory clinical and radiological outcomes were observed with daily activity level. The author reports this case and review the literature.

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Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection

et al. 2014

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Corticosteroid injections are widely used to treat enthesopathy and tendinitis, but are also associated with possible side effects, such as tendon degeneration or rupture. However, the mechanism of tendon degeneration or rupture after corticosteroid injection remains controversial. The purpose of this study was to reveal the mechanism of tendon degeneration or rupture after injection of triamcinolone acetonide (TA) or prednisolone (PSL). Forty-two rats were divided into 3 groups: A normal saline injection group (control group), a TA injection group, and a PSL injection group; the normal saline or corticosteroid was injected around the Achilles tendon. One or 3 weeks after injection, the tendons were subjected to biomechanical testing and histological analysis. At 1 week, the biomechanical strength was significantly lower in the corticosteroid groups. Histological analysis, at 1-week post-injection, showed collagen attenuation, increased expression of MMP-3 and apoptotic cells in the corticosteroid groups. The histological changes and biomechanical weaknesses of the tendon were not seen at 3 weeks. These alterations appeared to be involved in tendon degeneration or rupture after corticosteroid injection. ß

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Effect of steroid injections on the rotator cuff: An experimental study in rats

Cited by 122 publications

References 27 publications

Carrageenan‐induced subacromial bursitis caused changes in the rat's rotator cuff

Carrageenan‐induced subacromial bursitis caused changes in the rat's rotator cuff

Isolated Infraspinatus Tear and Suprascapular Nerve Neuropathy after Barbotage and Steroid Injection of Calcific Tendinitis

Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection

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