Effect of Statins on Collagen Type I Degradation in Patients With Coronary Artery Disease and Atrial Fibrillation

Statins as Antiarrhythmics: A Systematic Review Part I: Effects on Risk of Atrial Fibrillation

“…30 Statin therapy in patients with coronary artery disease and AF is associated with an increase in collagen degradation and an attenuation of inflammation, independently of cholesterol lowering. 31 An elevated level of hs-CRP has also been shown to be an independent risk factor for recurrent AF following initially successful direct current cardioversion in patients taking antiarrhythmic drugs. 32 However, although multiple studies have demonstrated that statins exhibit anti-inflammatory properties and were in fact associated with a lower incidence of postoperative AF, this effect appears to be independent of their effects on hs-CRP and IL-6 levels.…”

Effect of Statins in Preventing Postoperative Atrial Fibrillation Following Cardiac Surgery

“…30 And previous studies have also shown that atrial fibrosis with collagen deposition is the underlying substrate in AF, Kumagai also reported that a decreased fibrosis was found in all atrial regions in the atorvastatin group compared with the control group in a prospective study. 6,41,42 This evidence may imply that the anti-remodeling effect of statins may play an important role in preventing the occurrence of AF following cardiac surgery in some cases.…”

“…It used to be considered as lipid-lowering agents but more studies demonstrate a pleiotropic effect rather than lipid-lowering [30]. The anti-inflammatory property of statins has been suggested as one of the mechanisms by which they exhibit their protective role in parthenogenesis and possibly in the development of AF.…”

“…The anti-inflammatory property of statins has been suggested as one of the mechanisms by which they exhibit their protective role in parthenogenesis and possibly in the development of AF. 30 And the anti-inflammatory role of statins as a regulatory mechanism for AF has been used preoperatively to reduce the occurrence of AF following cardiac surgery, which showed great efficacy. [31][32][33] This beneficial effect of statins on AF has been described in different reports.…”

Beneficial Actions of Statins in the Reduction of Atrial Fibrillation and Stabilization and Regression of Coronary Plaques: But How and Why?

“…6-8 A recent study by Tziakas et al found that therapy with statins in patients with coronary artery disease and atrial fibrillation was associated with an increase in collagen degradation and an attenuation of inflammation, independent of cholesterol lowering. 9 Dr Das summarized the role of statins in the metabolism of essential fatty acids and their capacity to enhance the formation of antiinflammatory lipid molecules. He commented that measurement of plasma and tissue levels of lipoxins, resolvins, protectins and maresins may be used as markers of the development and progression of atrial fibrillation and atherosclerosis.…”