Effect of Statins on Cholesterol Crystallization and Atherosclerotic Plaque Stabilization

Abela, George S.; Vedre, Ameeth; Janoudi, Abed; Huang, Rao; Durga, Sridevi; Tamhane, Umesh

doi:10.1016/j.amjcard.2011.02.336

Cited by 103 publications

(60 citation statements)

References 18 publications

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“…Using a time course analysis, Duewell et al [16] revealed that small crystals appeared as early as 1 h after incubation with oxLDL and larger crystals were visible after longer incubation times. This is a significant finding considering the work by Abela et al [17], which showed the importance of statins in reducing crystal size.…”

Section: Lipoprotein Physiologymentioning

confidence: 52%

Dyslipidemia in Patients with Chronic and End-Stage Kidney Disease

Omran¹,

Al-Dadah

Dellsperger³

2013

Cardiorenal Med

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In this review, we discuss the physiology, diagnosis and treatment of dyslipidemia in patients with chronic and end-stage renal disease. The recent important clinical trials in patients with chronic kidney disease and dyslipidemia are reviewed. Because of the lack of evidence in treating lipid abnormalities in this specific patient population, we propose that future studies should focus on the pathophysiological mechanisms and treatment of dyslipidemia in this special patient population.

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Section: Lipoprotein Physiologymentioning

confidence: 52%

Dyslipidemia in Patients with Chronic and End-Stage Kidney Disease

Omran¹,

Al-Dadah

Dellsperger³

2013

Cardiorenal Med

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“…Our study suggests that using other agents that dissolve cholesterol crystals may have an important impact on no-reflow. It has already been demonstrated that alcohol, statins, aspirin, and high-density lipoproteins have an effect on dissolving cholesterol crystals (14,(35)(36)(37). Future studies may need to consider this novel aspect in the treatment of no-reflow.…”

Section: Discussionmentioning

confidence: 95%

The Impact of Circulating Cholesterol Crystals on Vasomotor Function

Gadeela

Rubinstein

Tamhane

et al. 2011

JACC: Cardiovascular Interventions

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“…5,9,25,26 Cholesterol crystallization and plaque volume expansion are also mitigated through direct statin effects. 3,5,7 Ultimately, the amalgamation of these beneficial effects results in a more advantageous plaque morphology. The lipid composition of plaques become more favorable and the collagen content will increase, resulting in a more fibrous and stable atheroma.…”

Section: Discussionmentioning

confidence: 98%