Effect of statins on aortic root growth rate in patients with bicuspid aortic valve anatomy

Regeer, Madelien V.; Rosendael, Philippe J. van; Kamperidis, Vasileios; Schalij, Martin J.; Bax, Jeroen J.; Marsan, Nina Ajmone; Delgado, Victoria

doi:10.1007/s10554-015-0749-0

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…Recently, statins have been found to exert biological effects on osteoporosis, inflammation and other diseases in addition to their hypocholesterolemic activities [29][30][31]. Furthermore, several studies have shown that treatment with statins can reduce reproductive damage induced by hypercholesterolemia, however, the mechanisms by which obesity impairs spermatogenic function and how statins help recover from obesity-induced damage in the testes, sperm parameters, sex hormones, and metabolism is still unclear [32].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR

Cui

Chen

Zhu

et al. 2017

Cell Physiol Biochem

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Background: Statins can reduce reproductive damage induced by obesity or high-fat diet (HFD), but the specific regulatory mechanisms are largely unknown. Since mTOR/p70s6k sinaling promotes spermatogonia proliferation and spermatogenesis, we hypothesized that this pathway will be involved in the protective effects of statin in HFD-induced reproductive dysfunction. Methods: Male Sprague Dawley rats (3 weeks old) were randomly divided into a control group (standard diet), HFD group, and a fluvastatin group (HFD + fluvastatin at 6mg/kg, once daily by oral gavage). After 8 weeks, body weight was obtain and rats were sacrificed. Weights of the testes, gross morphology, sperm parameters, circulating levels of sex hormones, lipid levels, and tissue mTOR, p-P70s6k were measured. Another set of male rats were treated with rapamycin or vehicle. Flow cytometry was used to detect the spermatogonia marker c-kit and cell cycle. p-P70s6k expression was analyzed by Western blot. Results: HFD not only results in rat obesity but also leads to spermatogenetic damage and fluvastatin was able to partially block the effects of HFD. Fluvastatin also partially reversed the suppression of mTOR and p-p70s6k expresson. Conclusion: Our data suggest that fluvastatin has protective effects on reproductive function in obese male rats most probably through enhanced signaling of mTOR.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR

Cui

Chen

Zhu

et al. 2017

Cell Physiol Biochem

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“…In patients with BAV aortopathy, medical management with b-blockers, angiotensin converting enzyme inhibitors, or statins has not been proven to be effective. [111][112][113] The optimal timing for surgical aortic replacement is controversial. An ascending aorta measuring 50 mm at its widest diameter had previously been cited to be an indication for surgery.…”

Section: Recommendations For Interventionmentioning

confidence: 99%

Canadian Cardiovascular Society 2022 Guidelines for Cardiovascular Interventions in Adults With Congenital Heart Disease

Marelli

Beauchesne

Colman

et al. 2022

Canadian Journal of Cardiology

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“…Statins have been shown to be ineffective, whereas other studies show a possible protective effect. 55…”

Section: Epidemiology and Natural Historymentioning

confidence: 99%

The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve–related aortopathy: Full online-only version

Borger

Fedak

Stephens

et al. 2018

The Journal of Thoracic and Cardiovascular Surgery

218

185

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Bicuspid aortic valve disease is the most common congenital cardiac disorder, being present in 1% to 2% of the general population. Associated aortopathy is a common finding in patients with bicuspid aortic valve disease, with thoracic aortic dilation noted in approximately 40% of patients in referral centers. Several previous consensus statements and guidelines have addressed the management of bicuspid aortic valve-associated aortopathy, but none focused entirely on this disease process. The current guidelines cover all major aspects of bicuspid aortic valve aortopathy, including natural history, phenotypic expression, histology and molecular pathomechanisms, imaging, indications for surgery, surveillance, and follow-up, and recommendations for future research. It is intended to provide clinicians with a current and comprehensive review of bicuspid aortic valve aortopathy and to guide the daily management of these complex patients.

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Effect of statins on aortic root growth rate in patients with bicuspid aortic valve anatomy

Cited by 11 publications

References 25 publications

Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR

Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR

Canadian Cardiovascular Society 2022 Guidelines for Cardiovascular Interventions in Adults With Congenital Heart Disease

The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve–related aortopathy: Full online-only version

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