Effect of statin on arginine metabolites in treated HIV-infection

Abstract

Background and aims Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide and an independent risk factor for cardiovascular disease. We examined the effect of statin on ADMA in HIV+ patients on stable ART, and whether such an effect contributes to the favorable changes on carotid intima media thickness. Methods This is a secondary analysis of SATURN-HIV, in which HIV+ adults on stable ART with HIV-1 RNA< 1,000 copies/mL and LDL-cholesterol <130 mg/dL were randomized to 10 mg daily rosuvastatin or placebo. Arginine metabolites, ADMA, and markers of inflammation were assessed at baseline and 48 weeks. Carotid intima media thickness (c-IMT) was measured at baseline, 48 and 96 weeks. Spearman correlations, and linear mixed-effect models were used to study relationships among variables. Results Overall, 79% were male, 68% African Americans, with a median age of 46 years. In the statin arm, no change in ADMA levels was observed at 48 weeks (0.70%), whereas a trend towards an increase in ADMA levels (23.78%) was observed in the placebo group (p=0.06). Elevated baseline ADMA (highest tertile) was associated with a 0.04 mm increase in c-IMT (p=0.03) after adjusting for statin and study duration. No interaction was seen between baseline ADMA and statin randomization on change in c-IMT (p=0.21). Conclusions In HIV+ subjects on ART, rosuvastatin suppressed the increase over time in ADMA levels. Elevated baseline levels of ADMA were associated with increases in c-IMT, regardless of statin assignment. The favorable effect of rosuvastatin on c-IMT appears to be independent of the arginine pathway.

Micronutrients, Metabolic Complications, and Inflammation in Ugandan Children With HIV

“…Overall, 172 participants were enrolled in this study and included in this analysis: 57 PHIV, 59 HEU, and 56 HIV− children. Detailed patient and maternal characteristics have been previously described (21). Median [Q1, Q3] age was 7.8 years [6.39, 8.84], 55% of participants were girls, median BMI was 15.2 kg/m 2 [14.38, 15.81] and 24% had food insecurity.…”

Effects of Physical Prehabilitation on the Dynamics of the Markers of Endothelial Function in Patients Undergoing Elective Coronary Bypass Surgery

“…Li et al revealed that simvastatin rapidly reduced plasma ET-1 concentrations in patients with chronic coronary heart disease: two-week simvastatin therapy reduced ET-1 by 44%, whereas no changes in ET-1 concentration were detected in the placebo group [ 37 ]. Moreover, scientific data indicate the ability of hydrophilic statins, such as rosuvastatin, to significantly reduce serum ADMA levels [ 47 ].…”

HIV-associated cardiovascular pathology

“…У ВИЧ-инфицированных пациентов, принимающих АРТ, назначение розувастатина статистически значимо уменьшало уровень ассиметричного диметиларгинина, оказывая защитное действие на эндотелий сосудов [19]. Розувастатин у ВИЧ-инфицированных вызывает иммунную активацию и приостанавливает развитие утолщения комплекса интима-медиа каротидных артерий.…”