Effect of splenectomy on Trypanosoma lewisi infection in young rats

Llende, Marta; Santiago-Delpín, Eduardo A.; Lavergne, J A

doi:10.1128/iai.40.3.1127-1133.1983

Cited by 4 publications

(2 citation statements)

References 7 publications

(6 reference statements)

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“…perhaps, surprising. Asplenic states are more often characterized by defects in defense as, for example, in the cases cited previously for T. lewisi (Haleem & Minton 1966, Llende et al 1983, Bahesia (Hussein 1979) and malaria (Wyler et al 1979, Eling 1980). In such cases, it would seem reasonable to attribute the defect in protection to a decreased production of specific antibody in the absence of the spleen.…”

Section: Discussionmentioning

confidence: 96%

The effect of splenectomy on resistance of mice to Entamoeba histolytica infection

Ghadirian

Kongshavn

1985

Parasite Immunology

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The role of the spleen in amoebic infection was examined in mice, using strains selected as being either genetically-susceptible (C57BL/6) or genetically-resistant (A/J) to amoebiasis. Splenectomized and sham-operated animals were inoculated intracaecally with 2.5 X 10(5) polyxenic trophozoites of E. histolytica at 6, 12 and 15 days post-splenectomy. The animals were killed 6 or 12 days after infection and the parasite burden was evaluated. Removal of the spleen in both susceptible and resistant mouse strains rendered these hosts extremely resistant to amoebic infection by this criterion. Gross examination of the caeca of non-splenectomized, genetically-susceptible mice showed numerous ulcers over the mucosal surface when compared to the splenectomized group which had superficial lesions or none. These observations suggest that the spleen plays a suppressive role in early anti-amoebic resistance.

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Section: Discussionmentioning

confidence: 96%

The effect of splenectomy on resistance of mice to Entamoeba histolytica infection

Ghadirian

Kongshavn

1985

Parasite Immunology

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“…Toki et al investigated that low dose RTx (<375 mg/BSA) on splenic B cell population in recipients of ABOi kidney transplantation and almost complete depletion of CD20 + B cell from spleen (23). However, it is known that even in a single dose of 375 mg/BSA RTx could deplete almost all of B cell in the spleen and peripheral blood, the effect to lymph nodes is weak and memory B cell and plasma cell can survive in lymph nodes, at least 75% or more of whole peripheral lymphoid tissue (16,24,25). Egawa et al reported that there was a tendency toward a higher incidence of AMR in patients treated with <300 mg/body compared with 500 or 375 mg/BSA (26).…”

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confidence: 99%

No diffuse intrahepatic biliary stricture after ABO-incompatible adult living donor liver transplantation using tailored rituximab-based desensitization protocol

Natsuda¹,

Muroya²,

Lee³

et al. 2021

Ann Transl Med

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Background: Rituximab (RTx) desensitization protocol offered good outcome in ABO-incompatible (ABOi) living donor liver transplantation (LDLT). However, diffuse intrahepatic biliary stricture (DIHBS) is still inevitable hurdle. We selectively added postoperative high dose intravenous immunoglobulin (IVIG) and/or simultaneous splenectomy if ABO isoagglutinin titer just before liver transplantation after plasma exchange (PE) was higher than 1/16. Herein, we reported the excellent outcome of ABOi LDLT without DIHBS using tailored desensitization protocol and compared it with that of ABO-compatible (ABOc) LDLT.Methods: Sixty-five cases (14.8%) of ABOi LDLTs were performed among 438 primary adult LDLTs in our center between March 2012 and June 2017. We performed 1-to-2 propensity score matching (PSM) to extract 60 cases of ABOi LDLTs and 120 cases of ABOc LDLTs.Results: There were no significant differences in clinical characteristics between ABOi and ABOc recipients. There were no significant differences in complications and rejection. There was no DIHBS in both groups. The 1-, 3-, and 5-year overall survival rates were 98.3%, 86.7%, and 82.9% in ABOi group and 96.7%, 86.7%, and 85.4% in ABOc group, respectively (P=0.88). Most common cause of deaths of both groups was hepatocellular recurrence. The 1-, 3-, and 5-year biliary complication (anastomosis leakage or stricture) free survival rates were 81.4%, 69.5%, and 67.5% in ABOi group and 83.0%, 81.3%, and 80.0% in ABOc group, with no significant differences (P=0.11).Conclusions: RTx-based tailored (optional IVIG + splenectomy) desensitization protocol for ABOi LDLT was feasible and acceptable.

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Increased resistance of splenectomized mice to Sporothrix schenckii infection

Miyaji

Nishimura

1986

Mycopathologia

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The susceptibility of splenectomized mice to Sporothrix schenckii was studied, and the role of the spleen in the host defense is discussed. S. schenckii Sp-1 and ddy male mice were used. The mice were divided into 3 groups consisting of splenectomized, sham-operated and intact mice. Each mouse was inoculated intravenously with 2 X 10(6) yeast cells 7 days after operation and the mice were sacrified at adequate intervals for 30 days. Then histological sections stained with H&E or by PAS were prepared from various visceral organs. Using the liver sections the number of yeast cells in a 40 mm2 was counted. Furthermore, the colony forming unit in 100 mg of the liver tissue was compared to each other. In the sham-operated and intact mice many purulent lesions appeared on the 5th day. On the 8th day mononuclear cells accumulated at the foci, and on the 10th day most of the foci became granulomatous. The number of yeast cells in granulomatous lesions reached a peak on the 10th day and thereafter decreased abruptly. On the other hand, in the splenectomized mice approximately half of foci became granulomatous on the 5th day, and the number of yeast cells in the foci began to decrease after the 5th day. There were definite differences in the colony forming unit between the splenectomized and sham-operated or intact mice sacrificed 9 days after inoculation. The colony forming unit of the former is 9.3 X 10(5) on the average, while that of the latter two is 5.6 X 10(6) and 5.1 X 10(6) on the average, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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Effect of splenectomy on Trypanosoma lewisi infection in young rats

Cited by 4 publications

References 7 publications

The effect of splenectomy on resistance of mice to Entamoeba histolytica infection

The effect of splenectomy on resistance of mice to Entamoeba histolytica infection

No diffuse intrahepatic biliary stricture after ABO-incompatible adult living donor liver transplantation using tailored rituximab-based desensitization protocol

Increased resistance of splenectomized mice to Sporothrix schenckii infection

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