Effect of Splenectomy on the Hæmodilutional Anæmia of Splenomegaly

Blendis, Laurence M.; Clarke, Margaret; Williams, Roger W.

doi:10.1016/s0140-6736(69)92064-9

Cited by 40 publications

(10 citation statements)

References 14 publications

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“…The gross reduction in plasma volume after splenectomy in the big spleen syndromes has already been frequently recorded (McFadzean, Todd, and Tsang, 1958;Blendis, Clarke, and Williams, 1969) although there is some evidence that the postsplenectomy blood volumes may still be higher than normal (Bowdler, 1970). The observations in this paper indicate that in the vast majority of splenomegalic patients the plasma volume is reduced with shrinkage of spleen size whereas the red cell mass remains constant.…”

Section: Discussionsupporting

confidence: 57%

The influence of spleen size on the distribution of red cells and plasma

Toghill

Green

1972

J Clin Pathol

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The red cell mass, splenic red cell pool, and plasma volume have been measured in a series of 64 patients with splenomegaly due to haematological disorders. In 45 patients the total blood volume was increased, this being due to expansion of the plasma volume which was closely correlated with spleen size. There was no significant relationship between the red cell mass and spleen size but the splenic red cell pool increased with increasing spleen size. In 12 patients serial estimations were made whilst changes in spleen size occurred as a result of therapy or progression of the disease. The red cell mass did not alter but the splenic red cell pool showed a significant change from 8·9 ± 6·1% of the red cell mass at minimum spleen size to 17·5 ± 10·5% at maximum spleen size. There was progressive expansion of the plasma volume from 42·9 ± 5·0 ml/kg at minimum spleen size to 57·4 ± 15·3 ml/kg at maximum spleen size.

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Section: Discussionsupporting

confidence: 57%

The influence of spleen size on the distribution of red cells and plasma

Toghill

Green

1972

J Clin Pathol

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“…The recorded increase in Hb during the first 30-50 days after splenectomy is parellel to a reduction in the increased plasma volume (Pryor 1967, Blendis et al 1969 which, however, rarely returns to normal in the course of this period (Pryor 1967, Bowdler 1970. T % 51Cr increases significantly after splenectomy (Egelund Christensen 1971a), and the total excretion of stercobilinogea decreases (Strumia et al 1962).…”

Section: Discussionmentioning

confidence: 97%

“…Thereby the increase in plasma volume contributes to reducing the peripheral haemoglobin concentration, viz. 'haemodilution anaemia', and regarding the erythrocyte pooling in the enlarged spleen the total red cell mass may be underestimated when judged from the venous haematocrit (Pryor 1967, Blendis et al 1969, Bowdler 1970. The increase in plasma volume seems to grow more marked with increasing splenomegaly (Blendis et al 1969), without the cause of the increased volume being known.…”

mentioning

confidence: 99%

Erythrocyte Pooling and Sequestration in Enlarged Spleens: Estimations of Splenic Erythrocyte and Fiasma Volume in Splenomegalic Patients

Christensen

1973

Scandinavian Journal of Haematology

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Erythrocyte pooling and sequestration in the spleen were studied in 73 patients with splenomegaly due to various haematological disorders using 51Cr-labelled autologous erythrocytes and surface counting. Arbitrary values for the accumulation of activity in spleens o f different sizes were obtained by correcting measured splenic surface activities (correction factors have been experimentally estimated). Absolute values for the splenic content of 51Cr and 1251 were obtained by comparative surface activity measurements over the enlarged spleen and a model of the spleen charged with a known amount of activity. In this way the splenic erythrocyte and plasma volume may be estimated.

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“…The high-dose irradiation had little effect on either peripheral blood CFU-C numbers or neutrophil counts and therefore irradiation of circulating blood cells probably cannot account for radiationinduced cytopenias in haematologically normal individuals. Unlike the brain, however, the spleen has the capacity to 'pool' blood (Blendis et al, 1969). The amount of splenic pooling of blood varies with the size of the organ and the disease process, but may account for 10-30% of the red cell mass.…”

Section: Discussionmentioning

confidence: 99%

Splenic Irradiation in Myelofibrosis: Effect on Circulating Myeloid Progenitor Cells

Koeffler¹,

Cline²,

Golde³

1979

Br J Haematol

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We have investigated the mechanism of splenic irradiation-induced granulocytopenia in two patients with myelofibrosis and marked splenomegaly. Serial assays were performed for circulating granulocyte-monocyte progenitors capable of colony formation in vitro (CFU-C). For comparison, similar studies were performed on two patients receiving whole brain irradiation for glioma. Splenic irradiation caused a significant decrease in circulating CFU-C in the myelofibrosis patients. There was no decrease in circulating CFU-C in the brain-irradiated patients. No radiation-induced humoral inhibitor of granulopoiesis and no increased CFU-C radiosensitivity could be demonstrated in the myelofibrosis patients. These observations, taken together with previous data on splenic blood flow and pooling, suggest that the major mechanism of irradiation-induced granulocytopenia in myelofibrosis is destruction of proliferating precursor cells in the splenic tissue and sinusoids.

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Effect of Splenectomy on the Hæmodilutional Anæmia of Splenomegaly

Cited by 40 publications

References 14 publications

The influence of spleen size on the distribution of red cells and plasma

The influence of spleen size on the distribution of red cells and plasma

Erythrocyte Pooling and Sequestration in Enlarged Spleens: Estimations of Splenic Erythrocyte and Fiasma Volume in Splenomegalic Patients

Splenic Irradiation in Myelofibrosis: Effect on Circulating Myeloid Progenitor Cells

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