Effect of spleen exposure to ultrasound on cellular and antibody-mediated immune reactions in man

Berthold, Frank; Berthold, Rita; Matter, I.; Reither, M; Rother, U.; Skvaril, F; Willems, Wulf R.

doi:10.1016/s0171-2985(11)80016-1

Cited by 8 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33,34 The authors reported reduced hemolysis and hemagglutination titers and varied immunoglobulin response in mice immunized with sheep red blood cells. Although controversial, 35,36 this early study sparked a series of publications throughout the 1980s on the interaction of US and the immune system. 33,[37][38][39][40] However, the mechanism underlying US modulation of the immune system was never determined, and this topic was seemingly disregarded.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway

Gigliotti

Huang

et al. 2013

Journal of the American Society of Nephrology

159

205

View full text Add to dashboard Cite

AKI affects both quality of life and health care costs and is an independent risk factor for mortality. At present, there are few effective treatment options for AKI. Here, we describe a nonpharmacologic, noninvasive, ultrasound-based method to prevent renal ischemia-reperfusion injury in mice, which is a model for human AKI. We exposed anesthetized mice to an ultrasound protocol 24 hours before renal ischemia. After 24 hours of reperfusion, ultrasound-treated mice exhibited preserved kidney morphology and function compared with sham-treated mice. Ultrasound exposure before renal ischemia reduced the accumulation of CD11b + Ly6G high neutrophils and CD11b + F4/80 high myeloid cells in kidney tissue. Furthermore, splenectomy and adoptive transfer studies revealed that the spleen and CD4 + T cells mediated the protective effects of ultrasound. Last, blockade or genetic deficiency of the a7 nicotinic acetylcholine receptor abrogated the protective effect of ultrasound, suggesting the involvement of the cholinergic anti-inflammatory pathway. Taken together, these results suggest that an ultrasound-based treatment could have therapeutic potential for the prevention of AKI, possibly by stimulating a splenic anti-inflammatory pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway

Gigliotti

Huang

et al. 2013

Journal of the American Society of Nephrology

159

205

View full text Add to dashboard Cite

show abstract

“…Child et al [612], who used τ ρ = 1 μ8 and v rcp = 690 Hz in an attempt to reproduce the findings of Anderson and Barrett [611], reported no immunosuppressive effect of ultrasound. Berthold et al [613] similarly reported no effect. There are a great many other studies involving the response to microsecond pulses of ultrasound, some of which will be examined at the end of this book, when mechanisms are discussed.…”

Section: (Ii) Continuous-wave and Millisecondmentioning

confidence: 93%

Effects and Mechanisms

Leighton

1994

The Acoustic Bubble

View full text Add to dashboard Cite

Ultrasound does not affect human lymphocyte transformation in vitro

Katoh

Charoensiri

1983

J of Clinical Ultrasound

View full text Add to dashboard Cite

The lymphocyte transformation test has been used in testing the effect of ultrasound on human lymphocytes. The test utilizes the mitogenic lectins, phytohemagglutinin, concanavalin A, and pokeweed mitogen to stimulate the incorporation of 3H-thymidine into resting lymphocytes after several days in culture. Ultrasound, which is increasingly used in diagnostic radiology, has been reported as an immunosuppressive agent in mice. Lymphocyte transformation has been used clinically as a test measuring the effectiveness of immunoenhancing and immunosuppressive therapies. The experiments reported here do not demonstrate an immunosuppressive role for ultrasound on human lymphocytes.

show abstract

Effect of spleen exposure to ultrasound on cellular and antibody-mediated immune reactions in man

Cited by 8 publications

References 8 publications

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway

Effects and Mechanisms

Ultrasound does not affect human lymphocyte transformation in vitro

Contact Info

Product

Resources

About