Effect of Spirulina maxima on spermatogenesis and steroidogenesis in streptozotocin-induced type I diabetic male rats

Nah, Won Heum; Koh, Il Kyoo; Ahn, Hae Sun; Kim, Mi Jeong; Kang, Hee-Gyoo; Jun, Jin Hyun; Gye, Myung Chan

doi:10.1016/j.foodchem.2012.02.085

Cited by 32 publications

(20 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These fertilising properties of D. arborea extract in diabetic rats could be attributed to the presence of some bioactive compounds such as sterols, phenols, flavonoids and saponins previously identified in these plant extracts (Watcho et al, ). These phytochemical compounds could then possess antioxidant effects capable to prevent oxidative stress in reproductive functions and structures (Bal et al, ; Chaiyasut et al, ; Kanter, Aktas, & Erboga, ; Khaki et al, ); insulin‐like (Schoeller et al, ) and androgenic potentials capable to stimulate the hypothalamic–pituitary–gonadal axis for the synthesis and secretion of testosterone as reported by other authors using other natural products (Ahangarpour et al, ; Chauhan, Saraf, & Dixit, ; Nah et al, ; Nna et al, ; Yakubu, Akanji, Oladiji, & Adesokan, ; Yoshitake, Yoshitake, & Kehr, ; Zha et al, ).…”

Section: Discussionmentioning

confidence: 85%

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

et al. 2019

View full text Add to dashboard Cite

Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D. arborea on some reproductive complications of diabetes in rats. Aqueous and ethanol (500 and 100 mg/kg respectively) extracts of D. arborea, Sildenafil citrate (1.44 mg/kg), trimethylamine‐N‐oxide (TMAO, 20 mg/kg) and distilled water (10 ml/kg) were orally administered for 28 days to streptozotocin‐induced diabetic rats. Glycaemia, body and reproductive organ masses, fertility parameters, total proteins, antioxidant enzymes activities, serum and testicular testosterone and the histology of the testes and epididymis were determined. Results revealed significant decreases in body and absolute and relative masses of testes, epididymis, seminal vesicles, prostate and vas deferens, fertility parameters, epididymal and testicular total proteins, serum and testicular testosterone levels as well as antioxidant enzymes activities. Interestingly, while having minor anti‐hyperglycaemic effects, these abnormalities associated with testicular and epididymal alterations were alleviated by D. arborea especially the aqueous extract (500 mg/kg). These outcomes provided evidence of the androgenic properties of D. arborea in diabetic rats, which could be useful for a better management of sexual dysfunctions in diabetic patients.

show abstract

Section: Discussionmentioning

confidence: 85%

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The housekeeping gene β-actin was used as a constitutive control for normalization. Primer sequences of rat 3β-HSD6, 17β-HSD3, Nr5A1, and β-actin were obtained from the published sequences of Nah et al (2012). The primer design was optimized for RT-PCR with EugeneTM version 2.2 (Daniben Systems, Cincinnati, OH, USA) (Table 1).…”

Section: Analysis Of Gene Expressions By Real-time Rt-pcr In Testiculmentioning

confidence: 99%

“…Spirulina platensis (Arthrospira platensis) is a natural source of vitamins, macronutrients and micronutrients like amino acids, gamma linolenic acid, carotenoids, especially β-carotene, α-linolenic acid, phycocyanin and phycocyanobil in chlorophyll, and xanthophyll phytopigments (Upasani and Balaraman 2003;Gong et al 2005;Bermejo et al 2008). The administration of Arthrospira produced a significant protective effects against oxidative damage caused by Cd in liver and kidney of rats (Jeyaprakash and Chinnaswamy 2005), nephrotoxicity of mercury in mice (Sharma et al 2007) as well as a protective role in the oxidative stress in nervous system of offspring from rats exposed to fluoride (Banjia et al 2013) and enhance the spermatogenesis and steroidogenesis in diabetic rats (Nah et al 2012). However, role of SP in ameliorating the reproductive dysfunctions induced by Cd is not fully established.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats

Farag

El-Aziz

Ali

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

The present study was conducted to evaluate the ameliorative efficacy of Spirulina platensis (SP) on reproductive dysfunctions induced by cadmium chloride (CdCl2) in male rats. Rats (n = 40) were divided into five groups (eight rats/each). Group 1: served as control without any treatment. Group 2: Rats were administered SP (150 mg/kg body weight (BW)) in drinking water for 10 days. Group 3: Rats were subcutaneously injected with CdCl2 (2 mg/kg BW) daily for 10 days. Group 4: Rats were co-treated with both CdCl2 (2 mg/kg BW) and SP (150 mg/kg BW) daily for 10 days (SP prophylactic group). Group 5: Rats received CdCl2 for 10 days followed by administration of SP alone in drinking water daily for another 30 days with the same mentioned routes and doses (SP treatment group). From our findings, the administration of SP alone or co-administration with Cd significantly attenuated the harmful effects of Cd, suggesting its beneficial role in improving spermatogenesis and steroidogenesis after Cd exposure.

show abstract

“…Increased expressions of StAR and 17β-HSD, with no significant effect on 3β-HSD, in addition to increased serum testosterone concentration are found in T1 diabetic rats treated with Spirulina maxima for 4 weeks. It is suggested that with the increased StAR protein expression compared to the DM group, more cholesterol would be delivered to the mitochondria of Leydig cells for testosterone synthesis (Nah et al, 2012). Kyathanahalli and Manjunath (2014) have reported an increase in expression of 3β-HSD in T1 diabetic rats following 15 days administration of Withania somnifera.…”

Section: Natural Products With Testicular Effects In Diabetes Mellitusmentioning

confidence: 99%

Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

2017

J App Pharm Sci

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycaemia, with multi-organ complications. DM is known to trigger oxidative stress in virtually all tissues of the body including male reproductive organs. Several experimental and clinical studies have reported varying degrees of male reproductive impairment in DM. Disruption in the hypothalamic-pituitary-gonadal axis, abnormal testicular energy metabolism, testicular and epididymal oxidative stress and oxidative stress-induced germ cell apoptosis have been reported in DM. The use of natural products in the treatment of various diseases is gaining more attention in experimental and clinical studies for the management and/or treatment of various diseases. In this review, the effects of DM on male reproductive system at pre-testicular, testicular and post-testicular levels are discussed. The role of various natural products including whole plant extracts and some pure compounds isolated from plants, with their suggested mechanism of actions is also reviewed.

show abstract

Effect of Spirulina maxima on spermatogenesis and steroidogenesis in streptozotocin-induced type I diabetic male rats

Cited by 32 publications

References 22 publications

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats

Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

Contact Info

Product

Resources

About