Effect of Spirulina biomass residue on yield and cordycepin and adenosine production of Cordyceps militaris culture

Iamtham, Siriluck; Kaewkam, Adisak; Chanprame, Sontichai; Pan-utai, Wanida

doi:10.1016/j.biteb.2021.100893

Cited by 9 publications

(1 citation statement)

References 25 publications

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“…EPS were obtained from ethanol precipitation of the FB, centrifugation, and freeze-drying. The yields of polysaccharides, cordycepin, adenosine, and proteins of the EPS, FB, MY and whole fermentation product (FBMY) were detected by the phenol-sulfuric acid method 46 high-performance liquid chromatography (HPLC) method 47 , and Bio-Rad Protein Assay (Bio-Rad, Hercules, CA, USA) according to the manufacturer's instructions, respectively (Table 1). The feed pellets of different experimental groups were produced by mixing 5% (w/w) dry weight of EPS, FB, MY, and FBMY with 95% Laboratory Rodent Diet 5001.…”

Section: Methodsmentioning

confidence: 99%

Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice

Lin

Hsu

Tsai

et al. 2022

Sci Rep

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Cordyceps militaris (CM) is a popular medicinal fungus; however, few studies have focused on its impact on the male reproductive system. We evaluated the effects of CM fermentation products on the reproductive development of juvenile male (JM) mice. Mice were divided into four experimental groups, each fed 5% CM products (weight per weight (w/w) in normal diet): extracellular polysaccharides (EPS), fermentation broth (FB), mycelia (MY), and whole fermentation products (FB plus MY, FBMY) for 28 days, while mice in the control group (CT) were fed a normal diet. Basic body parameters, testicular structure, sperm parameters, and sex hormones concentrations were analyzed. Compared to the CT group, mice in the EPS, MY, and FBMY groups showed a significantly increased mean seminiferous tubule area (p < 0.05), mice in the FB and MY groups had significantly higher sperm concentrations (p < 0.05), and mice in the EPS, FB, and FBMY groups showed significantly increased ratios of motile sperm (p < 0.05). Meanwhile, EPS significantly promoted the ability of JM mice to synthesize testosterone (p < 0.05). Furthermore, all CM products significantly increased the food intake of JM mice (p < 0.05) but did not significantly change their water intake and body weight gain (p > 0.05). In conclusion, CM products, especially EPS, exhibit strong androgen-like activities that can promote male reproductive development.

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Section: Methodsmentioning

confidence: 99%