Effect of spironolactone on mineralo and glucocorticoid — induced increases in colonic NA and water absorption and Na-K-ATPase activity

Effect of colchicine and vinblastine on rat intestinal water transport and Na -K-ATPase activity

“…We tested the hypothesis that colchicine and vinblastine, two microtubular disrupting agents (Olmstead and Borisy, 1973), inhibit water transport from the rat small intestine by inhibiting Na-K-ATPase activity, an enzyme which plays an important role in the intestinal absorption of sodium and water under basal conditions (Charney and Donowitz, 1977). injection of methyl prednisolone, 3 0 mg/100 g body weight (Upjohn, Belgium) was given 30 minutes before the intraperitoneal injection of either 0-15 M NaCl, colchicine, or vinblastine.…”