Effect of space flight on the behavior of human retinal pigment epithelial ARPE-19 cells and evaluation of coenzyme Q10 treatment

Cialdai, Francesca; Bolognini, Davide; Vignali, Leonardo; Iannotti, Nicola; Cacchione, Stefano; Magi, Alberto; Balsamo, Michele; Vukich, Marco; Neri, G.; Donati, Alessandro; Monici, Monica; Capaccioli, S.; Lulli, Matteo

doi:10.1007/s00018-021-03989-2

Cited by 12 publications

(16 citation statements)

References 106 publications

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“…In a recent paper, an Italian team set out to further explore the pathogenesis underlying SANS. Specifically, the molecular and cellular effects induced in human adult retinal pigment epithelium (ARPE-19) cells following incubation for three days in µ g onboard the ISS were investigated [ 99 ]. No changes in viability or apoptosis were observed during the µ g phase.…”

Section: Resultsmentioning

confidence: 99%

Current Knowledge about the Impact of Microgravity on Gene Regulation

Corydon

Schulz

Richter

et al. 2023

Cells

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Microgravity (µg) has a massive impact on the health of space explorers. Microgravity changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into deep space are being planned along with the commercialization of space travelling, researchers have focused on gene regulation in cells and organisms exposed to real (r-) and simulated (s-) µg. In particular, cancer and metastasis research benefits from the findings obtained under µg conditions. Gene regulation is a key factor in a cell or an organism’s ability to sustain life and respond to environmental changes. It is a universal process to control the amount, location, and timing in which genes are expressed. In this review, we provide an overview of µg-induced changes in the numerous mechanisms involved in gene regulation, including regulatory proteins, microRNAs, and the chemical modification of DNA. In particular, we discuss the current knowledge about the impact of microgravity on gene regulation in different types of bacteria, protists, fungi, animals, humans, and cells with a focus on the brain, eye, endothelium, immune system, cartilage, muscle, bone, and various cancers as well as recent findings in plants. Importantly, the obtained data clearly imply that µg experiments can support translational medicine on Earth.

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Section: Resultsmentioning

confidence: 99%

Current Knowledge about the Impact of Microgravity on Gene Regulation

Corydon

Schulz

Richter

et al. 2023

Cells

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“…Vitamin C and α-lipoic acid also had beneficial effects on motor symptoms and extended survival rates in rodents [ 93 ]. Coenzyme Q10, a component of mitochondrial membranes and a free radical scavenger, which has also been associated with anti-apoptotic effects [ 94 ], presents therapeutic effects in HD models. Antioxidants have also been tested in the psychiatric field.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia

et al. 2022

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Schizophrenia (SZ) is a deleterious brain disorder affecting cognition, emotion and reality perception. The most widely accepted neurochemical-hypothesis is the imbalance of neurotransmitter-systems. Depleted GABAergic-inhibitory function might produce a regionally-located dopaminergic and glutamatergic-storm in the brain. The dopaminergic-release may underlie the positive psychotic-symptoms while the glutamatergic-release could prompt the primary negative symptoms/cognitive deficits. This may occur due to excessive synaptic-pruning during the neurodevelopmental stages of adolescence/early adulthood. Thus, although SZ is not a neurodegenerative disease, it has been suggested that exaggerated dendritic-apoptosis could explain the limited neuroprogression around its onset. This apoptotic nature of SZ highlights the potential therapeutic action of anti-apoptotic drugs, especially at prodromal stages. If dysregulation of apoptotic mechanisms underlies the molecular basis of SZ, then anti-apoptotic molecules could be a prodromal therapeutic option to halt or prevent SZ. In fact, risk alleles related in apoptotic genes have been recently associated to SZ and shared molecular apoptotic changes are common in the main neurodegenerative disorders and SZ. PRISMA-guidelines were considered. Anti-apoptotic drugs are commonly applied in classic neurodegenerative disorders with promising results. Despite both the apoptotic-hallmarks of SZ and the widespread use of anti-apoptotic targets in neurodegeneration, there is a strikingly scarce number of studies investigating anti-apoptotic approaches in SZ. We analyzed the anti-apoptotic approaches conducted in neurodegeneration and the potential applications of such anti-apoptotic therapies as a promising novel therapeutic strategy, especially during early stages.

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“…Citicoline has been used in amblyopia [ 80 , 81 ], myopia [ 82 ], and restoring corneal sensitivity after laser-assisted in situ keratomileusis (LASIK) [ 83 ]. Additionally, CoQ10 has been used in spaceflight-associated neuro-ocular syndrome [ 84 ], in the prevention of keratocyte apoptosis after photorefractive keratectomy (PRK) [ 85 , 86 ], and even in diseases that have a hereditary component such as those already described (RP and LHON).…”

Section: Citicoline and Coq10: Concluding Remarksmentioning

confidence: 99%

“…In AMD, the use of CoQ10 in combination with other compounds seems to reduce the progression of retinal damage [ 66 , 67 ] and even reverse part of the accumulation of drusen [ 67 ]. In in vitro studies, it seems that both idebenone and CoQ10 exert a protective effect on RPE [ 56 , 84 ].…”

Section: Citicoline and Coq10: Concluding Remarksmentioning

confidence: 99%

The Role of Citicoline and Coenzyme Q10 in Retinal Pathology

García-López

Matamoros

et al. 2023

IJMS

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Ocular neurodegenerative diseases such as glaucoma, diabetic retinopathy, and age-related macular degeneration are common retinal diseases responsible for most of the blindness causes in the working-age and elderly populations in developed countries. Many of the current treatments used in these pathologies fail to stop or slow the progression of the disease. Therefore, other types of treatments with neuroprotective characteristics may be necessary to allow a more satisfactory management of the disease. Citicoline and coenzyme Q10 are molecules that have neuroprotective, antioxidant, and anti-inflammatory properties, and their use could have a beneficial effect in ocular neurodegenerative pathologies. This review provides a compilation, mainly from the last 10 years, of the main studies that have been published on the use of these drugs in these neurodegenerative diseases of the retina, analyzing the usefulness of these drugs in these pathologies.

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Effect of space flight on the behavior of human retinal pigment epithelial ARPE-19 cells and evaluation of coenzyme Q10 treatment

Cited by 12 publications

References 106 publications

Current Knowledge about the Impact of Microgravity on Gene Regulation

Current Knowledge about the Impact of Microgravity on Gene Regulation

Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia

The Role of Citicoline and Coenzyme Q10 in Retinal Pathology

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