Effect of soybean insoluble dietary fiber on prevention of obesity in high-fat diet fed mice <i>via</i> regulation of the gut microbiota

Wang, Bixiang; Yu, Hansong; He, Yang; Lian-kui, Wen; Gu, Jiadong; Wang, Xinyuan; Miao, X. Y.; Qiu, Guansheng; Wang, Haoran

doi:10.1039/d1fo00078k

Cited by 61 publications

(43 citation statements)

References 47 publications

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“…To solve the problem, we prepared high purity insoluble dietary fiber from okara (Okara-HPIDF) by enzymatic method, which purity could exceed 90% [16], and proved that it had potential bioactivities. Meanwhile, we proved that Okara-HPIDF had certain functions, such as improving lipid metabolism and so on [17,18]. In the process of studying its relationship with the changes of the colonic environment, we found that Okara-HPIDF could significantly change the composition of colonic flora [18].…”

Section: Introductionmentioning

confidence: 92%

“…Meanwhile, we proved that Okara-HPIDF had certain functions, such as improving lipid metabolism and so on [17,18]. In the process of studying its relationship with the changes of the colonic environment, we found that Okara-HPIDF could significantly change the composition of colonic flora [18]. This means that Okara-HPIDF was fully fermented by microorganisms in the colon, which may lead to changes in structure, composition, functionality, and even bioactivities of Okara-HPIDF.…”

Section: Introductionmentioning

confidence: 93%

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Changes of High-Purity Insoluble Fiber from Soybean Dregs (Okara) after Being Fermented by Colonic Flora and Its Adsorption Capacity

Lyu

Wang

Zhang

et al. 2021

Foods

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In order to explore the changes and properties of high-purity insoluble dietary fiber from okara (HPIDF) after entering the colon and be fermented by colonic flora, fermented high-purity insoluble dietary fiber (F-HPIDF) was obtained by simulated fermentation in vitro by HPIDF and colonic flora from C57BL/6 mice. For exploring the differences of HPIDF and F-HPIDF, the changes of structure (SEM. FTIR, XRD, particle size, specific surface area, monosaccharide composition) and adsorption properties (water, oil, heavy metal irons, harmful substances) of HPIDF/F-HPIDF were explored. The results showed that F-HPIDF had a higher water-holding capacity (19.17 g/g), water-swelling capacity (24.83 mL/g), heavy metals-adsorption capacity (Cd2+: 1.82 μmol/g; Pb2+: 1.91 μmol/g; Zn2+: 1.30 μmol/g; Cu2+: 0.68 μmol/g), and harmful substances-adsorption capacity (GAC: 0.23 g/g; CAC: 14.80 mg/g; SCAC: 0.49 g/g) than HPIDF due to the changes of structure caused by fermentation. In addition, with the fermentation of HPIDF, some beneficial substances were produced, which might be potential intestinal prebiotics. The study of F-HPIDF strengthens the speculation that HPIDF may have potential bioactivities after entering the colon, which proved that okara-HPIDF may have potential functionality.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 93%

Changes of High-Purity Insoluble Fiber from Soybean Dregs (Okara) after Being Fermented by Colonic Flora and Its Adsorption Capacity

Lyu

Wang

Zhang

et al. 2021

Foods

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“…Appropriate regulation of satiety is one of the important factors that connects diet, eating behaviors (e.g., meal size), and health. Table 4 [121][122][123][124][125][126][127][128] includes eight examples of recent studies and reviews on microbiota and the regulation of satiety. This review describes the control of multiple regulatory factors affecting satiety that are embedded within the gut microbiome.…”

Section: Satietymentioning

confidence: 99%

“…Appropriate regulation of satiety is one of the important factors that connects diet, eating behaviors (e.g., meal size), and health. Table 4 [ 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 ] includes eight examples of recent studies and reviews on microbiota and the regulation of satiety.…”

Section: Who Behavioral Modification #1: Eat a Healthy Diet (In Spite Of The Microbiota-driven Sense Control)mentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, and obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to comorbid NCDs.

show abstract

“…Appropriate regulation of satiety is one of the important factors that connects diet, eating behaviors (e.g., meal size), and health. Table 4 [121][122][123][124][125][126][127][128] includes eight examples of recent studies and reviews on microbiota and the regulation of satiety. In a recent review, Rautman and de la Serre [121] describe the multi-level influences of gut microbiota on a variety of mechanisms (e.g., both peripheral and central) determining satiety.…”

Section: Satietymentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert¹

2021

Preprint

View full text Add to dashboard Cite

The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to co-morbid NCDs.

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Effect of soybean insoluble dietary fiber on prevention of obesity in high-fat diet fed mice via regulation of the gut microbiota

Abstract: Increasing evidence has shown that the gut microbiota plays an important role in preventing obesity; however, the mechanism by which insoluble dietary fiber (IDF) prevents high-fat diet (HFD)-induced obesity remains unclear.

Cited by 61 publications

References 47 publications

Changes of High-Purity Insoluble Fiber from Soybean Dregs (Okara) after Being Fermented by Colonic Flora and Its Adsorption Capacity

Changes of High-Purity Insoluble Fiber from Soybean Dregs (Okara) after Being Fermented by Colonic Flora and Its Adsorption Capacity

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

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