Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Sagiri, Sai Sateesh; Kasiviswanathan, Uvanesh; Shaw, Gauri Shankar; Singh, Meenakshi; Anis, Arfat; Pal, Kunal

doi:10.1007/s11814-015-0295-4

Cited by 40 publications

(33 citation statements)

References 29 publications

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“…The formation of plate-like structure hinders solute migration [14]. On the contrary, the formation of fiber-like structures promotes solute migration [32]. Since the addition of stearic acid promotes formation of fibrous structures, which result in the formation of a mesh network, it was expected that the solute (in this case drug molecules) migration would be promoted.…”

Section: Discussionmentioning

confidence: 99%

Stearic Acid Modified Stearyl Alcohol Oleogel: Analysis of the Thermal, Mechanical and Drug Release Properties

Yadav

Kasiviswanathan

Soni

et al. 2017

J Surfact & Detergents

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The present study delineates the effect of stearic acid on the properties of stearyl alcohol oleogel. Herein, a series of oleogels were prepared by mixing different proportions of fatty alcohol (Stearyl alcohol; gelator) and fatty acid (stearic acid; co‐gelator). The characterization of the oleogels was done by thermal, macro‐scale stress relaxation, drug release, and antimicrobial studies. The oleogels were formed by the self‐assembly of stearyl alcohol/stearic acid. Thermal studies indicated that the stearic acid alters the crystal morphology, polymorphic transition and rate of crystallization of stearyl alcohol. The firmness of the oleogels with higher stearic proportion was better, which was due to the formation of a rigid network structure of stearyl alcohol in the presence of stearic acid. The release of ciprofloxacin hydrochloride, model drug, from the oleogels was better from the oleogels with higher stearic acid content. The release of the drug from the oleogels was Fickian diffusion‐mediated; except the oleogel with the highest stearic acid proportion. The antimicrobial study showed that the drug loaded oleogels were able to resist the growth of Escherichia coli, model microbe.

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Section: Discussionmentioning

confidence: 99%

Stearic Acid Modified Stearyl Alcohol Oleogel: Analysis of the Thermal, Mechanical and Drug Release Properties

Yadav

Kasiviswanathan

Soni

et al. 2017

J Surfact & Detergents

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“…The test was carried out for 2 h. The cumulative drug release (CPDR) profiles were determined (Figs. 12(a) and 12(b)) [14]. It was observed that the release of the drug was higher during iontophoresis as compared to the passive study.…”

Section: Resultsmentioning

confidence: 93%

Internet-of-Things-Enabled Dual-Channel Iontophoretic Drug Delivery System for Elderly Patient Medication Management

Reddy

Pradhan

Qureshi

et al. 2020

Journal of Medical Devices

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Wireless controllers have found its application in the supervision of the patients in the hospitals. It is not only a valid issue for the developing countries but also for the developed countries. For this reason, scientists are working on the advancement of medical devices that are capable of decreasing the workload of health caregivers. In this study, the development of an iontophoretic drug delivery device that could be controlled using a mobile is described. For the purpose, hardware and a software module were developed. The hardware module consisted of a two-channel voltage-controlled constant current sources that were used for driving the iontophoretic device. A mobile app was developed to control the two-channel iontophoretic device and to monitor the loose lead of the active and the passive patches. In the case of detection of the loose lead, the specific iontophoretic channel was stopped. Further, the audio-visual indicator was developed for the detection of the detachment of the patches (loose lead). The device was tested in vitro by performing the drug release study using drug-loaded emulsion gels that were formulated.

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“…In vitro drug release from organogels was performed through a dialysis membrane (HIMEDIA ® LA 330-5MT) in modified Franz diffusion cell [26]. Accurately weighed drug-loaded sample containing drug equivalent to 4 mg was placed in the donor compartment and the receptor chamber containing phosphate buffer (pH 5.8) was maintained at 32°C ± 0.5°C.…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

Comparative Study of Span 40 and Span 60 Based Soy-Gels for Topical Drug Delivery

Mukherjee¹,

Ash²,

Biswas³

et al. 2019

Asian J Pharm Clin Res

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Objective: Hydrogels or emulgels are recommended for topical application to elicit a local effect. However, they suffer from stability problems. The present study deals with the formulation and comparison of thermally stable soybean oil-based novel topical organogels (soy-gels) using two different gelators (Span 40 and Span 60) for controlled drug delivery. Methods: Soy-gels (8 batches) were developed with Span 40 and Span 60 by solid fiber mechanism and characterized for viscosity, gelation kinetics behavior, gel-sol transition parameters, drug content, in vitro drug release pattern, and changes occurring during accelerated thermal stability studies. Results: Fourier transformed infrared spectroscopic confirmed the compatibility among the organogel components and paracetamol. The formulations exhibited skin and hemocompatibility. The viscosity of Span 60 based soy-gels was found to be approximately 10 times higher than those of Span 40 based formulations. In comparison to Span 40, Span 60 induced faster gelation (3–6 min) of soybean oil at lower concentration (16% w/v) forming less flexible but thermally more stable soy-gels demonstrating higher Tg values. Higher flexibility and lower viscosity accounted for improved drug diffusion (both Fickian and non-Fickian) from Span 40 gels of varying concentrations in pH 5.8. However, zero-order drug release was observed in organogel with 18% w/v Span 40 only and all Span 60-based formulations except the one with 22% w/v Span 60. Non-Fickian drug diffusion occurred from Span 60 based soy-gels. A gradual increase in gelation time was observed until five cycles of freeze-thaw. Conclusion: Therefore, the choice of organogelator governs the rheological, thermal, and drug diffusion properties of soy-gels intended for topical application.

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Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Cited by 40 publications

References 29 publications

Stearic Acid Modified Stearyl Alcohol Oleogel: Analysis of the Thermal, Mechanical and Drug Release Properties

Stearic Acid Modified Stearyl Alcohol Oleogel: Analysis of the Thermal, Mechanical and Drug Release Properties

Internet-of-Things-Enabled Dual-Channel Iontophoretic Drug Delivery System for Elderly Patient Medication Management

Comparative Study of Span 40 and Span 60 Based Soy-Gels for Topical Drug Delivery

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