Effect of some Tropical Eggplant Fruits (Solanum Spp) Supplemented Diet On Diabetic Neuropathy In Experimental male Wistar Rats In-vivo

Abstract

Background: Solanum known as eggplant is a popular vegetable crop grown in the subtropics and tropics. Eggplant is a perennial but grown commercially as an annual crop. The fruits of eggplant is primarily used as a cooking vegetable for various dishes. Eggplant comes in various kinds of species, which are highly variable for its fruit colour, as well as shape and size.Content and Purpose of this study: This study focused on comparing the effect of dietary African eggplants (AP) Solanum kumba,(PG) Solanum gilo (PW) and Solanum aethiopicum (PGW) species. Diabetes was induced experimentally by high fat fed/low dose streptozotocin-diabetic rats (35 mg/kg body wt.) and the diabetic rats were fed diets supplemented with 20–40% supplemented eggplant diet for 14 days. The effect of the diets on the blood glucose level, pancreatic α-amylase, intestinal α-glucosidase and Angiotensin-I converting enzyme (ACE) activities, plasma antioxidant status were determined also quantification of the fruits polyphenols using HPLC/DAD .Results: The results revealed that there was no significant (P < 0.05) difference in the average feed intake and weight changes in all the groups. Supplementation with eggplant diet gradually reduced blood glucose level in diabetic rat compared to diabetic rats and metformin-treated (positive control group). African eggplant showed elevated levels of antioxidant status such as (glutathione peroxidase GPX, glutathione transferase GST,reduced glutathione GSH,Catalase and Ascorbic acid).Conclusions:The results suggest that the eggplant may attenuate hyperglycemia, hypertension and oxidative stress in the type 2 diabetic condition with Solanum kumba having the highest activity which could not be far fetched from its polyphenols as revealed in the HPLC/DAD characterization.Keywords: Solanum spp,polyphenols, diabetes,enzymes

Nutritional content of selected species of tropical eggplant fruit (Solanum spp) diet Attenuates hepatic inflammation in high‐fat fed male Wistar rats induced with streptozotocin

“…In the same vein, the inclusion of the tropical eggplant in the diet could restore and reverse the diabetic state of the diabetic model due to the presence of polyphenol and flavonoid constitutes as reported earlier by Nwanna et al. (, ) from the high‐performance liquid chromatogram, which depicts the individual phenolic acids and flavonoids. It was reported that the concentration of these constituents was more in S. kumba, which could have contributed to the observed activities.…”

“…The methods of Oboh and Ogunruku (2010), Srinivasan, Viswanad, Asrat, Kaul, and Ramara (2005), and Nwanna et al. () were used for the formulation of the food and the experimental design. Induction of rats to make them diabetic and the grouping were done according to the earlier studies reported by Nwanna et al.…”

“…Induction of rats to make them diabetic and the grouping were done according to the earlier studies reported by Nwanna et al. (). Various biochemical parameters were analyzed, the kidney was cut into small slices, and the method of Maynard and Downes () was used to preserve it and later use for histopathological structure viewing.…”

Eggplant (Solanum spp) supplemented fruits diet modulated the activities of ectonucleoside triphosphate diphosphohydrolase (ENTPdase), monoamine oxidase (MAO), and cholinesterases (AChE/BChE) in the brain of diabetic Wistar male rats

“…Studies by Nwanna, Ibukun, and Oboh (, ) and Anosike, Abonyi, and Ubaka () revealed an abundance of vitamin C, polyphenols and flavonoids in the local garden egg/eggplants with anti‐diabetes, anti‐ulcer properties. The report from Nwanna, Ibukun, et al () also confirmed that the inclusion of these eggplant fruits as part of the dietary composition could reduce the blood glucose level to 22%–50% lower than the hyperglycemia‐induced diabetes using an in vivo model. Studies on the neuroprotective property from the tropical eggplant in hyperglycemia‐mediated neurodegeneration are still lacking.…”

In-vitro characterization and biological properties of polyphenols extract of ripe garden egg (Solanum gilo)

“…It is the most important of the vegetable families which are essentially tropical in origin (Nwanna et al, 2013). Most species are wild but some of them such as S. aethiopicum, S. macrocarpon, S. kumba and S.gilo bear edible fruits in West African origin (Nwanna et al, 2016). Its fruits may be consumed freshly raw, dry or cooked.…”