Effect of some purified plasma proteins on collagen biosynthesis in vitro

Jp, Borel; Viellard, A; Randoux, A

doi:10.1007/bf01972210

Cited by 3 publications

(1 citation statement)

References 5 publications

(3 reference statements)

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“…Anti-inflammatory activity of steroidal antiinflammatory agents has been partly ascribed to increased cq ant• levels induced by these steroids [22]. Haptoglobin, another acute-phase reactant, has been found to inhibit proline incorporation into glycoproteins of connective tissue in vitro [23]. Since the anti-inflammatory effectiveness of endogenous anti-inflammatory substances, released into the circulation during inflammation, has recently received much attention [18,24], we tested the hypothesis that the spontaneous remission of 6-SAI arthritis could be due to such an endogenous mechanism.…”

Section: Discussionmentioning

confidence: 99%

6-Sulphanilamidoindazole arthritis of rats: Relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor

1980

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During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor alpha 2 macroglobulin (= alpha 2 acute phase globulin) and of Darcy's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups was proved to be significantly decreased. Intravenous administration of 5 mg/kg soybean trypsin inhibitor, twice daily for 4 days, was without any inhibitory effect on paw swelling in 6-SAI arthritis but it caused increased serum levels of alpha 2 macroglobulin and Darcy's glycoprotein. Thus, spontaneous remission of 6-SAI arthritis occurring, despite continued administration of 6-SAI, seems hardly likely to be caused by acute-phase reactants, e.g. via protease inhibition. Evidence is presented which shows that spontaneous remission of 6-SAI arthritis could be due to local processes.

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Section: Discussionmentioning

confidence: 99%

6-Sulphanilamidoindazole arthritis of rats: Relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor

1980

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Dynamics of serum interleukin-6 level in patients with acute myocardial infarction

Kucharz

Wilk

2000

European Journal of Internal Medicine

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Expression of haptoglobin-related protein and its potential role as a tumor antigen.

Kuhajda

Katumuluwa

Pasternack

1989

Proc. Natl. Acad. Sci. U.S.A.

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These studies describe the detection of a haptoglobin species, its characterization as the HPR gene product, and its association with both pregnancy and neoplasia. Previous work showed that the early recurrence of human breast cancer correlated with immunohistochemical staining with a commercial antiserum ostensibly directed against pregnancy-associated plasma protein A (PAPP-A). Use of this antiserum to guide purification ofthe putative antigen led to the present identification and purification of a strongly immunoreactive protein species distinct from PAPP-A that was present in the plasma of pregnant women at term. Unlike PAPP-A, a homotetramer of 200-kDa polypeptides, the immunoreactive protein consists of a light (a) chain (16.5 kDa) and a heavy (J6) chain (40 kDa); protein microsequencing of the 1 chain showed it to be a member of the haptoglobin family. The a chain of this haptoglobin species differs from ordinary haptoglobin 1 and 2 a chains both structurally and immunologically and represents the product of the HPR gene, haptoglobin-related protein (Hpr), since (i) the apparent molecular mass is the same as that predicted for Hpr a chain, (ii) the peptide map differs from that of haptoglobin 1 in a manner predicted by the HPR nucleotide sequence, (iii) monospecific antibodies that react with epitopes shared by the unique a chain and a synthetic peptide derived from the HPR nucleotide sequence do not detect these epitopes in either haptoglobin 1 or 2, and (iv) sequences of a-chain peptides were consistent with this identification, excluding haptoglobin 1 but not haptoglobin 2. The immunohistochemical reactivity of antibodies raised to the synthetic Hpr peptide is similar to that of anti-PAPP-A.Moreover, staining of neoplastic breast tissue is abolished by preincubation with purified Hpr.The present studies describe the expression of haptoglobinrelated protein (Hpr), the product of the HPR gene, and its association with both pregnancy and neoplasia. Conventional haptoglobins (Hps) have been well studied; the three known alleles each code for a precursor containing both the a and p8 chains (1-3). Maeda (4) described the HPR locus as a stretch of DNA located 2.2 kilobases downstream from the conventional HP locus. This sequence appears to be an intact gene

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Effect of some purified plasma proteins on collagen biosynthesis in vitro

Cited by 3 publications

References 5 publications

6-Sulphanilamidoindazole arthritis of rats: Relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor

6-Sulphanilamidoindazole arthritis of rats: Relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor

Dynamics of serum interleukin-6 level in patients with acute myocardial infarction

Expression of haptoglobin-related protein and its potential role as a tumor antigen.

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