Effect of Some Physical-Chemical Variables in the Synthesis of Hydroxyapatite by the Precipitation Route

García, Cristhian; Paucar, Carlos; Gaviria, Jaír; Durán, Alicia

doi:10.4028/www.scientific.net/kem.284-286.47

Cited by 13 publications

(7 citation statements)

References 9 publications

(13 reference statements)

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“…When as-synthesized particles remain in solution over time, irreversible changes usually occur such as growth and crystallization of the primary particles. [19][20][21] Thereby, the change in different parameters allows to obtain phosphates with different sizes, shapes and crystallinity or acidity character. [20][21][22][23] Several works on phosphate synthesis are reported in the literature [24][25][26][27] and some of them are focused on aluminum phosphate synthesis [28][29][30] and its thermal evolution.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21] Thereby, the change in different parameters allows to obtain phosphates with different sizes, shapes and crystallinity or acidity character. [20][21][22][23] Several works on phosphate synthesis are reported in the literature [24][25][26][27] and some of them are focused on aluminum phosphate synthesis [28][29][30] and its thermal evolution. 31 However, most studies refer to the orthophosphate case as has been mentioned above.…”

Section: Introductionmentioning

confidence: 99%

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Influence of the pH and ageing time on the acid aluminum phosphate synthesized by precipitation

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of the pH and ageing time on the acid aluminum phosphate synthesized by precipitation

et al. 2013

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“…Here, the nature and type of the mineral crystals are believed to be determined by the pH and initial Ca/P ratio, because the pH determines the relative ratios among H 2 PO 4 − , HPO 4 2− , and PO 4 3− . It has been reported that formation of HAP preferentially occurs at relatively high pH values, e.g., 10−12, [61][62][63]66 while HAP may also be formed at low pH values using a complexing agent or premixed HAP particles as seeds. 67,68 A significant body of literature has described the formation of HAP at elevated temperatures, followed by prolonged aging and sintering.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Role of Molecular Chemistry of Degradable pHEMA Hydrogels in Three-Dimensional Biomimetic Mineralization

Huang¹,

Liu²,

Song³

et al. 2012

Chem. Mater.

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Three-dimensional (3D) biomimetic mineralization is highly desired for soft biomaterials such as collagen to create useful hybrid biomaterials for orthopedic tissue engineering. Here, we apply an approach of current-mediated ion diffusion, as a feasible means of 3D biomimetic mineralization, to a series of generic, hydrolytically degradable poly(2-hydroxyethyl methacrylate) hydrogels with various molecular structures, imparted by the introduction of the comonomers, acrylic acid and 2-hydroxyethyl methacrylamide. This approach enables us to create a wide range of nanoscale single crystals of calcium phosphate within the hydrogels as characterized by high-resolution transmission electron microscopy (TEM). Molecular chemistry of the hydrogels, coupled with pH and gel strength, plays a crucial role in formation of the minerals. Both brushite (CaHPO 4 ·2H 2 O) and octacalcium phosphate (Ca 8 H 2 (PO 4 ) 6 ·5H 2 O) are observed in pHEMA homo hydrogel. Both octacalcium phosphate and monetite (CaHPO 4 ) are seen in a copolymer hydrogel, poly(2-hydrogelethyl methacrylate-co-acrylic acid). In another copolymer hydrogel (poly(2-hydroxyethyl methacrylate-co-2-hydroxyethyl methacrylamide), both hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) and monetite (CaHPO 4 ) are observed. All these nanocrystals are essential to bone regeneration. They organize themselves primarily as nanoscale fibers, sheets, needles, and clusters. These nanoarchitectures are important to bone-cell attachment, proliferation, migration, and differentiation, and dictate the ingrowth of new bone tissues.

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“…Solubility isotherms suggest the pH conditions required for the synthesis of specific CaPs, for example see [8]. HA is the least soluble CaP phase above pH 4.5 and precipitation has been reported between pH levels of 7.5 and 12.5 [9][10][11][12][13][14][15]. Under physiological conditions (37°C and pH 7.4) HA exhibits the lowest solubility and thus slowest dissolution rate followed by β-tricalcium phosphate [β-Ca 3 (PO 4 ) 2 -(β-TCP)].…”

Section: Introductionmentioning

confidence: 98%

The importance of processing conditions on the biological response to apatites

et al. 2015

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Hydroxyapatite (HA) is commonly synthesised via aqueous precipitation, however, the conditions used are wide ranging. As such, physiochemical properties of HA reported in the literature vary. This work demonstrates that alterations to synthesis conditions have impacts on material chemistry that may be difficult to detect using Xray diffraction and may compromise substrate cytocompatibility. Precipitation pH value was shown to be critical to synthesising cytocompatible HA substrates, which support MC3T3 adhesion, spreading, and proliferation. For the first time, pH control during synthesis, at 10 or 11, was demonstrated to improve cellular proliferation; a 49% increase in the number of metabolically active cells at day 7 was observed using an MTT assay. This is explained by the effect of pH on phase purity, stoichiometry, and surface charge. Promisingly, the novel use of a system containing toluene, a non-polar solvent, reduced crystallinity and increased surface area by 18% compared with apatite produced in deionised water. Ultimately, these physiochemical alterations enhanced the proliferative rate of MC3T3 osteoblast precursor cells by up to 150%.

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Effect of Some Physical-Chemical Variables in the Synthesis of Hydroxyapatite by the Precipitation Route

Cited by 13 publications

References 9 publications

Influence of the pH and ageing time on the acid aluminum phosphate synthesized by precipitation

Influence of the pH and ageing time on the acid aluminum phosphate synthesized by precipitation

Role of Molecular Chemistry of Degradable pHEMA Hydrogels in Three-Dimensional Biomimetic Mineralization

The importance of processing conditions on the biological response to apatites

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