Effect of some biochemical factors on female reproductive function

Abstract

The study aimed to determine the effect of certain biochemical factors on the female reproductive function. Analysis showed that two biochemical factors classified as inflammatory markers have a significant difference in their concentrations in women with impaired fertility and those without fertility disorders. These are C-reactive protein (CRP) and lactoferrin (LF). It is reasonable to assume that these inflammatory markers are associated to some extent with the development of reproductive disorders due to possible formation of inhibin A/LF complexes, which may reduce the biological activity of inhibin A, in patients’ serum. The effect of CRP on inhibin A activity is most likely to be systemic and associated with the effect of CRP high concentrations on inhibin A function on the body level. In particular, it is possible that CRP has an effect on IL-1βsynthesis in ovarian follicles.

Role of Microbial Factor in Male Infertility Pathogenesis. Literature Review

“…It is seen from the analysis of literature [7,8,9,10,11,12,13] that the species composition of microorganisms vegetating in the semen of healthy men is dominated by gram-positive microorganisms represented by genera Corynebacterium, Lactobacillus, Streptococcus and Staphylococcus (coagulase-negative species). The dominance of these groups of microorganisms in the semen of healthy men may be related to the peculiarities of seminal plasma: the presence of lysozyme, complement, secretory immunoglobulins, defensins, with their bactericidal action directed primarily against gram-negative microorganisms [14,15,16,17,18,19,20]. At the same time, the semen of infertile men shows a deficiency of coryneformic bacteria and lactobacilli and the presence of Gardnerella vaginalis and representatives of fecal flora, in particular bacteria of the family Enterobacteriaceae with dominating Escherichia coli, as well as gramnegative anaerobes Bacteroides spp.…”