Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects

Sonnenberg, G. E.; Keller, Ulrich; Perruchoud, André P.; Burckhardt, D; Gyr, K.

doi:10.1016/0016-5085(81)90015-9

Cited by 157 publications

(37 citation statements)

References 22 publications

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“…The findings of this study are, however, consistent among the blinded observers, and the observed flow changes (approximately 25% decrease) induced by somatostatin are similar to previously published data using the indocyanine green technique (approximately 27% decrease) [31]. Taking into account both the consistent measurements and the comparability with earlier reports, we suggest that using MRI is a good approach for estimating splanchnic blood flow.…”

Section: Discussionsupporting

confidence: 92%

“…within the gut [41]. Besides having effects on metabolism, somatostatin has been reported to induce a decrease in splanchnic blood flow [31,42]. The mode of action of somatostatin is not yet completely understood -it has been suggested that the reduction in splanchnic blood flow is induced through an increase in splanchnic arteriolar resistance and a decrease in portal and portosystemic collateral blood flow [43].…”

Section: Discussionmentioning

confidence: 98%

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Assessment of splanchnic blood flow using magnetic resonance imaging

Barthelmes

Parviainen²,

Vainio

et al. 2009

European Journal of Gastroenterology & Hepatology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Assessment of splanchnic blood flow using magnetic resonance imaging

Barthelmes

Parviainen²,

Vainio

et al. 2009

European Journal of Gastroenterology & Hepatology

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“…In addition to the actions on the GI tract itself somatostatin appears to have actions in the portal circulation to dilate vessels there (136,137).…”

Section: Actions Of Somatostatin On the Gastrointestinal Tractmentioning

confidence: 98%

Physiology and Pharmacology of LHRH and Somatostatin

McCann¹

1982

Annu. Rev. Pharmacol. Toxicol.

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“…Infusion of somatostatin, 7.5 pg min-', to patients with chronic liver disease and severe portal hypertension, has similarly been found to decrease both the liver blood flow and the wedged hepatic venous pressure (25). In contrast to these results, Sonnenberg et al (26) found no effect of somatostatin at a dosage of 250pg h-' on hepatic blood flow in patients with cirrhosis of the liver.…”

Section: Physiology and Pharmacologymentioning

confidence: 89%

Secretin and Somatostatin in the Treatment of Upper Gastrointestinal Haemorrhage

Magnusson¹

1987

Scandinavian Journal of Gastroenterology

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Magnusson I . Secretin and somatostatin in the treatment of upper gastrointestinal haemorrhage. Scand J Gastroenterol 1987, 22(suppl 137), 56-60Secretin inhibits gastric secretion of acid and gastrin in dog and a physiological role of sccretin as an enterogastrone has been suggested in this species. In man there are diverging results concerning the effect of secretin on gastric secretion. Secretin has been used in patients with upper gastrointestinal bleeding and po been reported, but the patients included in these studies cannot he considered as massive bleeders. Until now no double-blind study comparing secretin with placebo has been reported. Somatostatin decreases splanchnic blood flow and gastric secretion in man. Somatostatin seems to be effective in achieving initial haemostasis in patients with bleeding oesophageal varices. The pcptide has also been shown to stop severe and persistent peptic ulcer haemorrhage and to stop bleeding in patients treated with steroidal and non-steroidal anti-inflammatory drugs. In one double-blind trial in patients with upper gastrointestinal bleeding, somatostatin had no et'fect on either thc number of emergency operations or the number of rcbleedings. In another double blind study, when somatostatin was compared with placebo in patients with massive upper gastrointestinal bleeding, the peptide reduced the number of emergency operations. In conclusion. most studies show positive effects of somatostatin on variceal and peptic ulcer haemorrhage. SwedenScand J Gastroenterol Downloaded from informahealthcare.com by Indiana University on 12/13/14For personal use only.34. Coraggio F, Scarpato P, Spina M, Lombardi S. Br Med J 1984, 289, 224 Scand J Gastroenterol Downloaded from informahealthcare.com by Indiana University on 12/13/14For personal use only.

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Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects

Cited by 157 publications

References 22 publications

Assessment of splanchnic blood flow using magnetic resonance imaging

Assessment of splanchnic blood flow using magnetic resonance imaging

Physiology and Pharmacology of LHRH and Somatostatin

Secretin and Somatostatin in the Treatment of Upper Gastrointestinal Haemorrhage

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