Effect of solvents on anti-inflammatory and analgesic activities of leaves extract of Mussa paradisiaca Linn

Chougule, Poonam; Nargatti, Prakash; Kothali, Pooja; Chougule, Nilesh

doi:10.52711/0974-360x.2023.00626

Cited by 1 publication

(1 citation statement)

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“…Our findings align with the few existing toxicological studies of M. paradisiaca byproducts. No apparent acute toxicity of leaf extracts from Indian bananas and peel extracts from Mexico bananas was observed in rodent models [53][54][55]. Nevertheless, an earlier study of Nigerian banana (M. paradisiaca) leaf has shown moderate acute toxicity of the aqueous fraction from ethanolic extract to mice [56].…”

Section: Discussionmentioning

confidence: 99%

Valorization of Nam Wah Banana (Musa paradisiaca L.) Byproducts as a Source of Bioactive Compounds with Antioxidant and Anti-inflammatory Properties: In Vitro and In Silico Studies

Widoyanti,

Chaikong,

Rangsinth

et al. 2023

Foods

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Nam Wah banana (Musa paradisiaca L.) is the most common banana cultivar in Thailand. Large amounts of its non-consumable byproducts are considered undervalued and thrown as waste. Exploring the potential utilization and application of banana byproducts for human benefit can add to their value and minimize the risk of threats. This study aimed to investigate phytochemicals, antioxidant and anti-inflammatory activities, and toxicity of Nam Wah banana byproducts. Five banana plant parts, including the midrib, leaf, peduncle, unripe and ripe peels, were extracted using hexane, ethyl acetate, ethanol, and water. Among the extracts tested, the ethyl acetate leaf extract showed the strongest antioxidant capacity and anti-inflammatory activity, probably through the inhibition of inducible nitric oxide synthase (iNOS) and 15-lipoxygenase (15-LOX). Positive correlations existed between the activities and the total phenolic/flavonoid content of banana byproducts. An in silico docking analysis demonstrated that flavonoid glycosides in banana byproducts, such as kaempferol-3-O-rutinoside and rutin, may bind to inducible iNOS, whereas omega-3-polyunsaturated fatty acids, such as eicosapentaenoic acid, may bind to 15-LOX and cyclooxygenase-2 (COX-2). The extracts showed either low or no toxicity. These findings suggest that banana byproducts are a natural source of antioxidant and anti-inflammatory compounds. It is recommended that additional investigations be conducted to explore their potential therapeutic applications in treating disorders linked with oxidative stress or inflammation. This research has the potential to enhance the value of banana byproducts.

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Section: Discussionmentioning

confidence: 99%