Effect of Solvent Viscosity on the Driven Translocation of Charged Polymers through Nanopores

Hu, Han-Xian; Wu, Fan; Yang, Xiao; Wang, Chao; Luo, Meng‐Bo

doi:10.1007/s10118-022-2696-2

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Increasing the viscosity of the solvent again reduces the mobility of the DNA strands, resulting in longer translocation times. The capture rate can be increased by creating a viscosity gradient across the pore; the gradient basically gives rise to the pumping effect [ 47 , 50 , 60 , 137 , 241 , 242 ]. Changing the temperature of the solvent has similar effects, temperature can affect solution properties such as viscosity and conductivity and thus affects the translocation time.…”

Section: Controlling the Speed Of Translocationmentioning

confidence: 99%

Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges

Singh

Chauhan

Bharadwaj

et al. 2023

IJMS

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Various biological processes involve the translocation of macromolecules across nanopores; these pores are basically protein channels embedded in membranes. Understanding the mechanism of translocation is crucial to a range of technological applications, including DNA sequencing, single molecule detection, and controlled drug delivery. In this spirit, numerous efforts have been made to develop polymer translocation-based sequencing devices, these efforts include findings and insights from theoretical modeling, simulations, and experimental studies. As much as the past and ongoing studies have added to the knowledge, the practical realization of low-cost, high-throughput sequencing devices, however, has still not been realized. There are challenges, the foremost of which is controlling the speed of translocation at the single monomer level, which remain to be addressed in order to use polymer translocation-based methods for sensing applications. In this article, we review the recent studies aimed at developing control over the dynamics of polymer translocation through nanopores.

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Section: Controlling the Speed Of Translocationmentioning

confidence: 99%

Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges

Singh

Chauhan

Bharadwaj

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Molecular Chaperone-Dependent Polymer Translocation through Nanopores: The Effects of Chaperone Concentration and Chaperone-Polymer Interaction

Zuo,

Wang,

Sun

et al. 2023

Chin J Polym Sci

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Translocation of two-dimensional active polymers through nanopores using Langevin dynamics simulations

Hu,

Shen,

Luo

2024

The Journal of Chemical Physics

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The translocation of polymers through nanopores is a complex process influenced by various factors. In this study, the translocation behavior of a two-dimensional active polymer chain, comprised of a head active Brownian particle (ABP) and a tail passive polymer chain, through a nanopore is studied using Langevin dynamics simulations. Results show that the effect of the self-propulsion force of the ABP on the translocation differs significantly from the driving force inside the pore for traditional polymer translocations. Specifically, the translocation time τ initially increases with increasing the magnitude fs of the self-propulsion force and then decreases with a further increase in fs. A small fs lowers the potential barrier for the translocation and thus promotes slow translocations, whereas a large fs directly pulls the polymer chain through the nanopore following the scaling relation τ ∝ fs−1. Moreover, two asymptotic scaling relations between τ and polymer length N, τ ∝ Nα, are found, with the exponent α of about 2.5 for small fs or long N and the exponent α of about 1.4 for short active polymers with large fs. We discover that the slow rotation of the ABP accelerates the translocation process.

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Effect of Solvent Viscosity on the Driven Translocation of Charged Polymers through Nanopores

Cited by 3 publications

References 44 publications

Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges

Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges

Molecular Chaperone-Dependent Polymer Translocation through Nanopores: The Effects of Chaperone Concentration and Chaperone-Polymer Interaction

Translocation of two-dimensional active polymers through nanopores using Langevin dynamics simulations

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