Effect of solvent and additives on the electrospinnability of BSA solutions

Garcia, Javier Nevado; Félix, Manuel; Cordobés, F.; Guerrero, Y Antonio

doi:10.1016/j.colsurfb.2022.112683

Cited by 9 publications

(5 citation statements)

References 82 publications

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“…[42] In general, BSA-based constructs exhibit viscoelastic, biocompatible, high surface area, swelling resistant, efficient enzyme encapsulation in filtering, and free shapeable features. [24,43,44] Various biomedical applications of these albumin-based constructs are attributed to robust mechanical properties such as rapid self-recovery rate, excellent tensile and compressive strength. [45] Furthermore, the biofunctionalization of synthetic polymers via nanometer BSA protein can significantly enhance their netting points of the web, interfiber bondings, and eventually, the elastic modulus.…”

Section: Mechanical Strengthmentioning

confidence: 99%

“…While rigidizing the structure of the polymeric network, these chemical bonds would hinder the movement between the chains and prevent NFs formation. [ 24 ]…”

Section: Structural and Physicochemical Propertiesmentioning

confidence: 99%

“…Meanwhile, BSA favors solvent evaporation by bringing the charges to the solution and inducing disruption of the network formed by the HPMC molecule. [ 24 ] Similarly, Afza et al. have reported the electrospun synthesis of PCL‐BSA‐HA scaffold.…”

Section: Electrospun Synthesismentioning

confidence: 99%

“…As a result, augmenting the demand for co‐electrospinning with synthetic polymers or potentially using toxic reagents ultimately leads to poor biocompatibility. [ 24 ] Fourthly, high viscosity and surface tension could enhance the formation of helix‐shaped fibers while electrospinning and sometimes even poor flow through the needle. This problem needs to be addressed to optimize the structural features and biological activity of NFs.…”

Section: Existing Challengesmentioning

confidence: 99%

“…[21,22] While taking unconventional platforms, multiple recent reports have shown successive ultrafine BSA fibers synthesis via electrospinning with applications in various fields such as filtering, active packagings, biosensors, tissue engineering, drug delivery, wound dressings, cancer therapy, and bone repairing. [23,24] This review begins by introducing the structural and physicochemical characteristics of BSA. Next, we highlighted recently reported extraction and determination methods of BSA.…”

Section: Introductionmentioning

confidence: 99%

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Electrospinning of bovine serum albumin‐based nano‐fibers: From synthesis to medical prospects; Challenges and future directions

Hayat,

Bukhari,

Irfan

2023

Biotechnology Journal

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Bovine serum albumin (BSA) is a globular non‐glycoprotein that has gotten a lot of attention because of its unique properties like biocompatibility, biodegradability, non‐immunogenicity, non‐toxicity, and strong resemblance to the natural extracellular matrix (ECM). Given its robust mechanical properties, such as interfacial tension, conductivity, swelling resistance, and viscoelasticity, it can be concluded that it is an appropriate matrix for producing novel BSA‐based nanoconstructs. Thus, simple analytic methods are required for accurately detecting BSA as a model protein in medical sciences and healthcare. Furthermore, the characteristics mentioned above aid BSA in the electrospinning process, which results in fibres conjugated with other polymers. Electrospun synthesis has recently received much attention for its ability to produce stable, biomimicking, highly porous, 3D BSA‐derived nano‐fibers. As a result, BSA‐based nano‐fibers have achieved exclusive developments in the medical sector, such as tissue engineering for the remodelling of damaged tissue or organ repair by creating artificial ones.Meanwhile, they could be used as drug delivery systems for target‐specific drug delivery, wound dressings, etc. This study illustrates the structural and physicochemical properties of BSA and the determination of BSA using various methods, by citing recent reports and current developments in the medical field. Furthermore, current challenges and future directions are also highlighted.This article is protected by copyright. All rights reserved

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Section: Mechanical Strengthmentioning

confidence: 99%

“…While rigidizing the structure of the polymeric network, these chemical bonds would hinder the movement between the chains and prevent NFs formation. [ 24 ]…”

Section: Structural and Physicochemical Propertiesmentioning

confidence: 99%

Section: Electrospun Synthesismentioning

confidence: 99%

Section: Existing Challengesmentioning

confidence: 99%