Effect of soluble receptors to interleukin‐1 and tumor necrosis factor alpha on experimentally induced root resorption in rats

Zhang, Dongliang; Goetz, Werner; Braumann, Bert; Bourauel, Christoph; Jaeger, Andreas

doi:10.1034/j.1600-0765.2003.00410.x

Cited by 37 publications

(30 citation statements)

References 49 publications

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“…23,24,30 This could also be due to the anti-inflammatory effect of LIPUS, 31 as it has been reported to decrease the tumor necrosis factor-a or interleukin-1b 31 that are also involved in the proliferation and differentiation of odontoclast cells. 32 Our findings are in accordance with previous reports 15,25,30,31 that showed significantly fewer RL in LIPUS-treated teeth compared to control teeth, except for at the distal surface. The distal surface in the LIPUS group showed a lower number of RL compared to the control; however, this difference was not significant.…”

Section: Discussionsupporting

confidence: 83%

Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind, controlled clinical trial

Raza

Major

Dederich

et al. 2015

The Angle Orthodontist

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Objectives: To evaluate the effects of low-intensity pulsed ultrasound (LIPUS) on orthodontically induced tooth root resorption caused by torque in human subjects. Materials and Methods: Ten healthy patients (12-35 years of age) who required extraction of all first premolars as a part of their routine orthodontic treatment were recruited. A 15u twist was applied in the arch wire using 0.019 3 0.025-inch TMA in a 0.022-inch bracket system (Synergy R) that produced a buccal root torque of approximately 5 N/mm at the bracket level. Using a split mouth design, randomization, and blinding, one side of the arch received LIPUS for 20 minutes per day for 4 weeks at an incident intensity of 30 mW/cm 2 of the transducers' surface area. The other side served as a self-control, which received a sham transducer. After 4 weeks, all first premolars were extracted and micro-computed tomographic analysis was performed on these extracted teeth. A linear mixed-model statistical analysis was used. Results: LIPUS-treated teeth showed significantly less total volume of resorption lacunae compared to control teeth by a mean difference of (0.54 6 0.09 mm 3 ) (P , .001) and percentage of root resorption by a mean difference of (0.33 6 0.05 mm 3 ) (P , .001). In addition, significantly fewer resorption lacunae were found on all root surfaces in the LIPUS group compared to the control except in the instance of the distal surface. Limitations: This study was performed on limited number of cases during a 4-week period. Conclusions: LIPUS minimizes root resorption when applied during torque tooth movement over a 4-week period. (Angle Orthod. 2016;86:550-557.)

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Section: Discussionsupporting

confidence: 83%

Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind, controlled clinical trial

Raza

Major

Dederich

et al. 2015

The Angle Orthodontist

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“…23 Those factors can stimulate RANKL expression and are important for the induction and the further process of root resorption in the rat. 24,25 These findings suggest that the effect of nicotine on root resorption may act via various cytokines and signal pathways and further verify our hypothesis that the aggravated root resorption caused by nicotine is related to the elevated expression of RANKL. However, the role that nicotine is playing in this biologic process of root resorption is still incompletely understood, and whether other doses of nicotine or longer exposure time to nicotine may influence the process of root resorption during OTM should be further investigated.…”

Section: Discussionsupporting

confidence: 68%

Short-term effects of nicotine on orthodontically induced root resorption in rats

Wang

et al. 2015

The Angle Orthodontist

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Objective: To investigate the effect of nicotine exposure on root resorption in an in vivo rat model of orthodontic tooth movement (OTM), and its association with odontoclastogenesis and receptor activator of nuclear factor-kappa B ligand (RANKL) expression. Materials and Methods: Forty-eight 10-week-old male Wistar rats were divided into three groups. The negative control group was untreated. The left maxillary first molars in the nicotine-treated group and the positive control group received OTM with an initial force of 0.6 N in the mesial direction. Also, the nicotine-treated group received intraperitoneal injection of nicotine at 7 mg/kg per day. After 21 days, the rats were humanely killed. Eight rats from each group were randomly chosen for crater volume analysis by micro-computed tomography. For the remaining eight rats in each group, specimen slices were generated for histologic examination to determine the odontoclast number and the mean optical density value of RANKL. Results: The resorption volumes in the nicotine-treated group were significantly larger than those in the control groups. Also, the nicotine-treated group displayed significantly higher number of odontoclasts and elevated RANKL expression compared to the control groups. Conclusions: In an in vivo rat model, nicotine exposure promotes odontoclastogenesis and RANKL expression, evoking aggravated root resorption during OTM.

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“…Whatever its extent, RR caused by orthodontic treatment does not generally progress once treatment is complete [46,61]. Thus, even highly resorbed teeth may fulfill their function properly years after treatment has finished [50].…”

Section: Introductionmentioning

confidence: 99%

Severe external apical root resorption—local cause or genetic predisposition?

et al. 2011

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Effect of soluble receptors to interleukin‐1 and tumor necrosis factor alpha on experimentally induced root resorption in rats

Abstract: Our results indicate that IL-1 and more particularly TNFalpha are important for the induction and the further process of mechanically induced root resorption in the rat.

Cited by 37 publications

References 49 publications

Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind, controlled clinical trial

Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind, controlled clinical trial

Short-term effects of nicotine on orthodontically induced root resorption in rats

Severe external apical root resorption—local cause or genetic predisposition?

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