Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats

Hannan, J. M. A.; Rokeya, Begum; Nahar, Nilufar; Mosihuzzaman, M; Khan, Aka; Ali, Liaquat

doi:10.1016/s0378-8741(03)00190-9

Cited by 122 publications

(68 citation statements)

References 12 publications

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“…4 Literature data confirm the significant effects of alternative medicine to control hyperglycemia 5,6 and lipid levels. [7][8][9] Hypercaloric diets are very common nowadays and increase the occurrence of hypercholesterolemia and low levels of high-density lipoprotein-cholesterol (HDL-c), resulting in higher risks of cardiovascular diseases. 10 Hypercholesterolemia and low HDL-c levels may be associated with endothelium dysfunction and inflammation, which are often followed by atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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The aim of this study was to evaluate the effects of Passiflora edulis f. flavicarpa Degener (yellow passion) juice on the lipid profile and oxidative stress status of Wistar rats. Adult male Wistar rats were divided in two groups (n = 8 animals per group): the control group, which received water, and the treated group, which was given P. edulis juice (1,000 mg/kg). Both groups received by gavage treatment twice a day for 28 days. The treated group showed an increased high-density lipoproteincholesterol level and decreased low-density lipoprotein-cholesterol and free fatty acid levels compared with the control group. Levels of triglycerides and and very low-density lipoprotein-cholesterol, superoxide dismutase activity, and total glutathione concentration were not statistically different between the two groups, but the thiobarbituric acid-reactive substances concentration (indicating lipid peroxidation) decreased in the treated group. These findings suggests that P. edulis juice in the experimental conditions used showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats.

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Section: Introductionmentioning

confidence: 99%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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“…Administering fenugreek soluble fiber orally twice daily at a dose of 0.5 g/ kg for 28 days resulted in reducing the serum fructosamine level with no significant change in the insulin level when compared with the control. It is concluded that soluble fiber had a beneficial effect on dyslipidemia and it could inhibit platelet aggregation in Type 2 model diabetic rats (37). Moreover, it has been reported that soluble fiber of fenugreek postpones digestion and absorption of carbohydrate resulting improvement of glucose homeostasis (38).…”

Section: Health and Therapeutic Benefits Of Fenugreek Seedmentioning

confidence: 98%

Fenugreek: Potential Applications as a Functional Food and Nutraceutical

Khorshidian¹,

Asli²,

Arab³

et al. 2016

Nutr Food Sci Res

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A B S T R A C TFenugreek (Trigonella foenum graecum), native to southern Europe and Asia, is an annual herb with white flowers and hard, yellowish brown and angular seeds, known from ancient times, for nutritional value beside of it medicinal effects. Fenugreek seeds are rich source of gum, fiber, alkaloid, flavonoids, saponin and volatile content. Due to it's high content of fiber, fenugreek could be used as food stabilizer, adhesive and emulsifying agent to change food texture for some special purposes. Some evidences suggest that fenugreek may also be regarded as antidiabetic, anticarcinogenic, remedy for hypocholesterolemia and hypoglycemia, antioxidant, antibacterial agent, gastric stimulant, and anti-anorexia agent. The present article is aimed to review the potential applications of fenugreek as a functional food and nutraceutical.

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“…Besides these linoleic and linolenic acid; g-lactone, sotolone (responsible for characteristic odor); diosgenin, trigocoumarin, trigomethylcoumarin, fibre and mucilage is also present [227]. Fenugreek seed in powder or germinated form exhibits anti-diabetic properties [228], hypocholesterolaemic effect [229] and effect on thyroxine-induced hyperglycaemia [230]. Fenugreek seeds have been used as an oral insulin substitute, and seed extracts have been reported to lower blood glucose levels [231].…”

Section: Plants Possessing Hypoglycemic Activitymentioning

confidence: 99%

A Review of Recent Investigations on Medicinal Herbs Possessing Anti-Diabetic Properties

Aggarwal¹,

Shishu²

2011

J Nutrition Disorder Ther

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Globally, the pervasiveness of chronic, non-communicable disease diabetes mellitus is growing by leaps and bounds. It is one of the major causes of premature morbidity and mortality worldwide. Almost 3.2 million people die of diabetes across the world every year. The worldwide prevalence of diabetes is 6.4% (corresponding to 285 million people); this varies from 10.2% in the Western Pacific to 3.8% in the African region and expected to grow up to 7.4% (439 million) of the adult population by 2030. In the last 20 years there has been a threefold increase in the prevalence of diabetes. It is estimated that there are 30 to 33 million diabetics in India now, and every fourth diabetic in the world today is an Indian. Indians are genetically more susceptible to diabetes and the WHO predicts the number of diabetics in India would go up to 80 million by 2030. WHO has also issued a warning that India is going to be the diabetes capital of the world with Chennai emerging as the diabetic capital of India. Many plants possessing hypoglycemic principles/ properties are known to exist in nature. Also a large number of polyherbal formulations (PHF's) derived from these plants are presently being prescribed as medicinal/dietary supplements for diabetes mellitus. Even the WHO (World Health Organization) approves the use of plant drugs for different diseases, including diabetes mellitus. However, these formulations lack proper standardization of the active constituents. There is an urgent need to address to the issues of scientific authenticity about their efficacy, safety and their interaction with modern allopathic drugs. The paper reviews composition, active principles and pharmacological effects of some important plants which are widely used in commercially available herbal and polyherbal formulations and provides a detailed list of plants reported to possess potential anti-diabetic activity.

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Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats

Cited by 122 publications

References 12 publications

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Fenugreek: Potential Applications as a Functional Food and Nutraceutical

A Review of Recent Investigations on Medicinal Herbs Possessing Anti-Diabetic Properties

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