Effect of Solcoseryl in Corneal Alkali Burn Rat Model

Kim, Hoon; Kim, Hong-Bee; Seo, Jae‐Hwi; Lee, Dong Cho; Cho, Kyong Jin

doi:10.25289/ml.2021.10.1.22

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Its mechanism has been suggested to work by enhancing corneal epithelial cell migration and proliferation, with increased expression of mucin genes [ 7 ]. In another experiment, rat cornea treated with Solcoseryl after alkali burn showed a trend of improved epithelial healing, but its difference from the control did not reach statistical significance, which agrees with the results of our study [ 34 ]. These findings suggest that though Solcoseryl may enhance epithelial cell migration and proliferation, it may lack the anti-inflammatory properties needed in the acute phase of chemical burns; therefore, limited healing effects were observed in this study.…”

Section: Discussionsupporting

confidence: 89%

Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model

Song

Ku²,

Kim³

et al. 2023

Korean J Ophthalmol

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Purpose: To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model.Methods: In 40 male Sprague-Dawley rats, we induced alkali burn using filter paper soaked in 0.2N sodium hydroxide. The rats were then treated with topical 0.5% RCI001, 1.0% RCI001, Solcoseryl, or PDRN twice a day for 2 weeks. Corneal epithelial integrity and epithelial healing rate were measured at day 0, 3, 5, 7, 10, and 14. Histologic and immunohistochemistry findings were also assessed.Results: Both the 0.5% and 1.0% RCI001 groups showed significantly more epithelial healing compared to the control group at day 5, 7, 10, and 14 (each <i>p</i> < 0.05). No statistical difference was found between the 0.5% and 1.0% RCI001 groups. Neither the Solcoseryl nor the PDRN groups showed a significant difference from the control. RCI001 treatment resulted in significantly reduced stromal edema, and a trend towards less inflammatory cell infiltration.Conclusions: Topical application of RCI001 showed enhanced corneal epithelial wound healing in the murine corneal alkali burn model, presumably by suppressing inflammation. Meanwhile, Solcoseryl and PDRN did not show sufficient therapeutic effects compared to RCI001.

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Section: Discussionsupporting

confidence: 89%

Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model

Song

Ku²,

Kim³

et al. 2023

Korean J Ophthalmol

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Indolent corneal ulcer in dogs

Oleynik¹

2022

Russian Veterinary Journal

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The article summarizes the most up-to-date scientific research data, clinical experience of foreign colleagues and the author of the article regarding the indolent corneal ulcer in dogs. The modern view on the etiopathogenesis of the pathology is disclosed detailly. The clinical signs and forms of chronic corneal epithelial defects (CCED) are described. The entire list of drugs used for the therapeutic treatment of dogs with CCED is presented. Along with this, drugs are indicated the use of which is not rational for this type of corneal ulcers. The criteria for choosing a treatment approach and the principles of drawing up the therapeutic treatment regimens are described in the article. The method of surgical treatment, their advantages, and results are listed.

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Effect of Solcoseryl in Corneal Alkali Burn Rat Model

Cited by 2 publications

References 18 publications

Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model

Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model

Indolent corneal ulcer in dogs

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